Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

Autor: Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau

Publikováno v: ESC Heart Failure, Vol 10, Iss 1, Pp 334-341 (2023)

Abstract Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury. However, its impact on post‐ischaemic remodelling indepe

Externí odkaz: https://doaj.org/article/ff12a4b41a044c2dbe150ec1060b1b94

Risk prediction of bleeding and MACCE by PRECISE-DAPT score post-PCI

Autor: Lisa Dannenberg, Shazia Afzal, Natalia Czychy, René M'Pembele, Saif Zako, Carolin Helten, Philipp Mourikis, Dorothee Zikeli, Samantha Ahlbrecht, Kajetan Trojovsky, Marcel Benkhoff, Maike Barcik, Georg Wolff, Tobias Zeus, Malte Kelm, Amin Polzin

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 33, Iss , Pp 100750- (2021)

Background: Guidelines recommend the PRECISE-DAPT (PD) score to adapt duration of dual antiplatelet therapy due to bleeding risk. However, there is first evidence that PD predicts mortality and ischemic events as well. Methods: We investigated PD Sco

Externí odkaz: https://doaj.org/article/9ffe6d3ec2e0477eb6d2f68b7ff59b88

Sphingosine-1-phosphate improves outcome of no-reflow acute myocardial infarction via sphingosine-1-phosphate receptor 1

Autor: Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau

Publikováno v: ESC heart failureReferences.

Therapeutic options targeting post-ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine-1-phosphate (S1P) reduces ischaemia/reperfusion injury. However, its impact on post-ischaemic remodelling independently of its infarct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64ec7960fcb0d2abae5b72eb7dbbf25
https://pubmed.ncbi.nlm.nih.gov/36217778

MTX Treatment Does Not Improve Outcome in Mice with AMI

Autor: Marcel Benkhoff, Bodo Levkau, Aysel Ayhan, Tobias Petzold, Kajetan Trojovsky, Saif Zako, Ragnar Huhn-Wientgen, Philipp Mourikis, Carolin Helten, Lisa Dannenberg, Amin Polzin, Denis Ignatov, René M'Pembele, Tobias Zeus, Theresia Sarabhai, Malte Kelm

Publikováno v: Pharmacology. 106:225-232

Background: Targeting inflammation in patients with coronary artery disease and/or acute myocardial infarction (AMI) is a matter of debate. Methotrexate (MTX) is one of the most widely used immunosuppressants. Cardiovascular Inflammation Reduction Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f105a92c0c82bc72ea9e95d8c3a664b2
https://doi.org/10.1159/000511279

Excess Mortality in Aspirin and Dipyrone (Metamizole) Co‐Medicated in Patients With Cardiovascular Disease: A Nationwide Study

Autor: Amin, Polzin, Lisa, Dannenberg, Carolin, Helten, Martin, Pöhl, Daniel, Metzen, Philipp, Mourikis, Christof, Dücker, Ursula, Marschall, Helmut, L'Hoest, Beata, Hennig, Saif, Zako, Kajetan, Trojovsky, Tobias, Petzold, Christian, Jung, Bodo, Levkau, Tobias, Zeus, Karsten, Schrör, Thomas, Hohlfeld, Malte, Kelm

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Pain is a major issue in our aging society. Dipyrone (metamizole) is one of the most frequently used analgesics. Additionally, it has been shown to impair pharmacodynamic response to aspirin as measured by platelet function tests. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::32efa7a8b491a09daf5c1dbb27a689b2
https://www.ahajournals.org/doi/10.1161/JAHA.121.022299