Characterization of HIV-1 Infection and Innate Sensing in Different Types of Primary Human Monocyte-Derived Macrophages

Autor: Elisabeth A. Diget, Kaja Zuwala, Randi K. Berg, Rune R. Laursen, Stine Søby, Lars Østergaard, Jesper Melchjorsen, Trine H. Mogensen

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

Macrophages play an important role in human immunodeficiency virus (HIV) pathogenesis and contribute to establishment of a viral reservoir responsible for continuous virus production and virus transmission to T cells. In this study, we investigated t

Externí odkaz: https://doaj.org/article/6d1d2d9709754c578161dd7559a7f417

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

Autor: Mohamed Abdel-Mohsen, Jacob D. Estes, Martin Tolstrup, Manuel Schmidt, Kathleen Busman-Sahay, Line K. Vibholm, Andrew V. Kossenkov, Kathrine Kjær, Rikke Olesen, Michel Bach Hellfritzsch, Paul W. Denton, Michael Nekorchuk, Leila B. Giron, Lars Østergaard, Maria Louise Kobberø, Chi Ngai Chan, Tine Engberg Damsgaard, Peter Ahlburg, Mariane H. Schleimann, Jens R. Nyengaard, Phillipp Schommers, Florian Klein, Burghardt Wittig, Kaja Zuwala, Frederik H. Rothemejer, Harsh Dweep, Ole Schmeltz Søgaard

Publikováno v: Schleimann, M H, Kobberø, M-L, Vibholm, L K, Kjær, K, Giron, L B, Busman-Sahay, K, Chan, C N, Nekorchuk, M, Schmidt, M, Wittig, B, Damsgaard, T E, Ahlburg, P, Hellfritzsch, M B, Zuwala, K, Rothemejer, F H, Olesen, R, Schommers, P, Klein, F, Dweep, H, Kossenkov, A, Nyengaard, J R, Estes, J D, Abdel-Mohsen, M, Østergaard, L, Tolstrup, M, Søgaard, O S & Denton, P W 2019, ' TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes ', EBioMedicine, vol. 45, pp. 328-340 . https://doi.org/10.1016/j.ebiom.2019.07.005
EBioMedicine

Background TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lymp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb90886f03eb60b2c74bf7f1b076a347
https://doi.org/10.1016/j.ebiom.2019.07.005

Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects

Autor: Lise L. Sørensen, Camilla Frich Riber, Alexander N. Zelikin, Paulina Gajda, Martin Tolstrup, Anna H. F. Andersen, Kaja Borup Løvschall, Kaja Zuwala

Publikováno v: Journal of Controlled Release
Riber, C F, Zuwala, K, Løvschall, K, Andersen, A H F, Sørensen, L, Gajda, P, Tolstrup, M & Zelikin, A N 2018, ' Macromolecular prodrugs of ribavirin : Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects ', Journal of Controlled Release, vol. 275, no. April, pp. 53-66 . https://doi.org/10.1016/j.jconrel.2018.02.012

Macromolecular (pro)drugs hold much promise as broad-spectrum antiviral agents as either microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity exists in combining the two modes of antiviral activity in the sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d1b0fcfad603e39dc75ed2ab14fcf2
http://europepmc.org/articles/PMC7114659

HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat

Autor: Martin Tolstrup, Anton A. A. Smith, Kaja Zuwala, Alexander N. Zelikin

Publikováno v: Chemical Science
Zuwala, K, Smith, A A A, Tolstrup, M & Zelikin, A N 2016, ' HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat ', Chemical Science, vol. 7, no. 3, pp. 2353-2358 . https://doi.org/10.1039/c5sc03257a

Self-immolative linker and a disulfide trigger are used to design macromolecular prodrugs of panobinostat as efficacious HIV latency reversing agents.
Histone deacetylase inhibitors (HDACi) and panobinostat in particular are currently in the foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafd5fd35f4f189dd6eb5665779d4ff1
https://doi.org/10.1039/c5sc03257a

Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells

Autor: Camilla Frich Riber, Alexander N. Zelikin, Thomas Pietschmann, Martin Tolstrup, Kaja Zuwala, Lærke Anegaard Rolskov, Anna H. F. Andersen, Frederik Dagnæs-Hansen, Dominic H. Banda, Paulina Gajda, Kaja Borup Løvschall

Publikováno v: Riber, C F, Halling Folkmar Andersen, A, Anegaard Rolskov, L, Zuwala, K, Gajda, P, Borup Løvschall, K, Dagnæs-Hansen, F, Banda, D H, Pietschmann, T, Tolstrup, M & Zelikin, A N 2017, ' Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells ', ACS Macro Letters, vol. 6, no. 935-940, pp. 935-940 . https://doi.org/10.1021/acsmacrolett.7b00471

Synthetic polymers make strong contributions as tools for delivery of biological drugs and chemotherapeutics. The most praised characteristic of polymers in these applications is complete lack of pharmacological function such as to minimize the side

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c8191c1d250e7728b18664848f1c84
https://pure.au.dk/portal/da/publications/synthetic-polymer-with-a-structuredriven-hepatic-deposition-and-curative-pharmacological-activity-in-hepatic-cells(9134d4f3-5802-4c4e-b8ad-e593958be9de).html