Výsledky vyhledávání - "Kaja Kostyrko"

Akademický článek

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma

Autor: Kaja Kostyrko, Marta Román, Alex G. Lee, David R. Simpson, Phuong T. Dinh, Stanley G. Leung, Kieren D. Marini, Marcus R. Kelly, Joshua Broyde, Andrea Califano, Peter K. Jackson, E. Alejandro Sweet-Cordero

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract KRAS is a frequent driver in lung cancer. To identify KRAS-specific vulnerabilities in lung cancer, we performed RNAi screens in primary spheroids derived from a Kras mutant mouse lung cancer model and discovered an epigenetic regulator Ubiq

Externí odkaz: https://doaj.org/article/bfd9eceda508466c9e02d6a2c91e89f7

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Supplementary Table 2 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Autor: Peter K. Jackson, Michael C. Bassik, E. Alejandro Sweet-Cordero, Dana M. Gwinn, Keene L. Abbott, Phuong T. Dinh, Kaitlyn Spees, Edwin E. Jeng, Nancie A. Mooney, Kyuho Han, Kaja Kostyrko, Marcus R. Kelly

This table lists genes whose protein products were identified by AP/MS experiments in HEK293 cells or A549 cells on the indicated sheets. The columns are as follows. Bait: bait protein (gene-wise); Prey, prey protein (gene-wise); Background Values :

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17545d535176e239c083fae187e28803
https://doi.org/10.1158/2159-8290.22535068.v1

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Supplementary Table 7 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Results from the "Paralog" sublibrary screen. Different metrics are reported on each of the three tabs of the spreadsheet as indicated. GI-T-Score : GIT Score; MWU Adj Pval: FDR of Mann-Whitney U Test p-value after Benjamini-Hochberg correction; Doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429524b487d1abe5296698d72e57e607
https://doi.org/10.1158/2159-8290.22535053.v1

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Supplementary Table 4 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Results from the single-target sgRNA screen in A549-Cas9 cells. The columns are as follows. Symbol : HUGO gene symbol ; EnsemblID : EnsEMBL identifier ; GeneID : Entrez Gene ID ; GeneInfo : Name of protein encoded by the gene ; Localization : GO cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3ea3ebf87a9378069d33a40b0a6d10
https://doi.org/10.1158/2159-8290.22535062

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Supplementary Table 5 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Results from the first pairwise sgRNA screen in A549-Cas9 and H23-Cas9 cells. Columns are as in the previous table, except that they refer to Gene A or Gene B as indicated, where the symbol for GeneA comes alphabetically before the symbol of Gene B.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c71e4ec9cd251a81717dcd8424745ae
https://doi.org/10.1158/2159-8290.22535059

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Supplementary Table 3 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

This spreadsheet contains 6 tabs, with each tab corresponding to a cell line and GO namespace. For each indicated bait (columns), all hits detected with FDR{less than or equal to}0.05 were searched for enrichment for the indicated term (row) using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8966fce4484628efab16b09a1755f95a
https://doi.org/10.1158/2159-8290.22535065.v1

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Data from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Activating mutations in RAS GTPases drive many cancers, but limited understanding of less-studied RAS interactors, and of the specific roles of different RAS interactor paralogs, continues to limit target discovery. We developed a multistage discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f6567cbbc36f819f6a04eb6710ff197
https://doi.org/10.1158/2159-8290.c.6547750.v1

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Supplementary Table 6 from Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities

Results from the "GI-Directed" sublibrary screen. Different metrics are reported on each of the three tabs of the spreadsheet as indicated. GI-T-Score : GIT Score; MWU Adj Pval: FDR of Mann-Whitney U Test p-value after Benjamini-Hochberg correction;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c783a3859da5fdf3f3a61ede73113b
https://doi.org/10.1158/2159-8290.22535056.v1

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