Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kaja Hoyer"'
Autor:
Elena Mylonas, Kenichi Yoshida, Mareike Frick, Kaja Hoyer, Friederike Christen, Jaspal Kaeda, Matthias Obenaus, Daniel Noerenberg, Cornelius Hennch, Willy Chan, Yotaro Ochi, Yuichi Shiraishi, Yusuke Shiozawa, Thorsten Zenz, Christopher C. Oakes, Birgit Sawitzki, Michaela Schwarz, Lars Bullinger, Philipp le Coutre, Matthew J. J. Rose-Zerilli, Seishi Ogawa, Frederik Damm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.
Externí odkaz:
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37
Autor:
Christopher Maximilian Arends, Marlene Weiss, Friederike Christen, Claudia Eulenberg-Gustavus, Anthony Rousselle, Ralph Kettritz, Kai-Uwe Eckardt, Willy Chan, Kaja Hoyer, Mareike Frick, Lars Bullinger, Markus Bieringer, Adrian Schreiber, Frederik Damm
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/ca1c15b339dd447eb702db890f912a73
Autor:
Mareike Frick, Franziska Briest, Frederik Damm, Antje Maluck-Böttcher, Cornelius Hennch, Friederike Christen, Kaja Hoyer, Raphael Hablesreiter, Annett Madadi, Angela Segler, Lars Bullinger
Publikováno v:
Leukemia. 36:1102-1110
To investigate clonal hematopoiesis associated gene mutations in vitro and to unravel the direct impact on the human stem and progenitor cell (HSPC) compartment, we targeted healthy, young hematopoietic progenitor cells, derived from umbilical cord b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b7ff8025975ad123c6c14c9d5cb8c9
https://doi.org/10.1038/s41375-021-01469-x
https://doi.org/10.1038/s41375-021-01469-x
Autor:
Christopher C. Oakes, Elena Mylonas, Yusuke Shiozawa, Lars Bullinger, Matthias Obenaus, Daniel Noerenberg, Mareike Frick, Michaela Schwarz, Matthew J. J. Rose-Zerilli, Kenichi Yoshida, Friederike Christen, Yotaro Ochi, Willy Chan, Frederik Damm, Jaspal Kaeda, Philipp le Coutre, Yuichi Shiraishi, Seishi Ogawa, Thorsten Zenz, Birgit Sawitzki, Kaja Hoyer, Cornelius Hennch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3708a3b78d2b6ca5768702654f70b0
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37
Autor:
Esther Schuler, Michael Koldehoff, Florian Kuchenbauer, Armin Gerbitz, David Michonneau, Maximilian Christopeit, Tomasz Zemojtel, Gérard Socié, Guido Kobbe, Joel Galan-Sousa, Eva Wagner, Felicitas Thol, Adriane Halik, Raphael Hablesreiter, Mareike Frick, Johannes Schetelig, Christian Thiede, Friederike Christen, Olga Blau, Kaja Hoyer, Frederik Damm, Kenichi Yoshida, Michael Heuser, Nicolaus Kroeger, Martin Bornhäuser, Francis Ayuk, Igor Wolfgang Blau, Willy Chan, Hubert Schrezenmeier, Daniel Noerenberg, Emmanuelle Clappier, Michael Stadler, Bernd M. Spriewald, Lars Bullinger, Seishi Ogawa, Christopher Maximilian Arends, Verena Wais, M Wiesneth
Publikováno v:
Journal of Clinical Oncology. 37:375-385
Purpose Clonal hematopoiesis of indeterminate potential (CHIP) occurs in the blood of approximately 20% of older persons. CHIP is linked to an increased risk of hematologic malignancies and of all-cause mortality; thus, the eligibility of stem-cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e6e28d1c238a6cae17430ad5b53e49
https://doi.org/10.1200/jco.2018.79.2184
https://doi.org/10.1200/jco.2018.79.2184
Autor:
Uwe Pelzer, Hanno Riess, Tetsuichi Yoshizato, Frederik Damm, Franziska Briest, Seishi Ogawa, Nobuyuki Kakiuchi, Yusuke Shiozawa, Yoshikage Inoue, M. Sinn, Kenichi Yoshida, Sven Bischoff, Jana Käthe Striefler, Yuichi Shiraishi, Michael Hummel, Lars Bullinger, Kaja Hoyer, Philipp Lohneis, Olga Blau, R. Hablesreiter, Friederike Christen, Hein Putter, U. Keilholz
Publikováno v:
EBioMedicine
EBioMedicine, Vol 66, Iss, Pp 103327-(2021)
EBioMedicine, 66. ELSEVIER
EBioMedicine, Vol 66, Iss, Pp 103327-(2021)
EBioMedicine, 66. ELSEVIER
Background: high recurrence rates of up to 75% within 2 years in pancreatic ductal adenocarcinoma (PDAC) patients resected for cure indicate a high medical need for clinical prediction tools and patient specific treat-ment approaches. Addition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdc8db3f67b13341cc29efe84c09374
https://pubmed.ncbi.nlm.nih.gov/33862582
https://pubmed.ncbi.nlm.nih.gov/33862582
Autor:
Friederike Christen, Mareike Frick, Kai-Uwe Eckardt, Anthony Rousselle, Claudia Eulenberg-Gustavus, Willy Chan, Lars Bullinger, Markus Bieringer, Marlene Weiss, Ralph Kettritz, Adrian Schreiber, Kaja Hoyer, Christopher Maximilian Arends, Frederik Damm
Publikováno v:
Haematologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772b3454defe00ccff51d2002ce099c1
http://edoc.mdc-berlin.de/18468/1/18468oa.pdf
http://edoc.mdc-berlin.de/18468/1/18468oa.pdf
Autor:
Joel Galan-Sousa, Markus Bieringer, Kaja Hoyer, Marlene Weiss, Adrian Schreiber, Friederike Christen, Claudia Eulenberg-Gustavus, Lars Bullinger, Mareike Frick, Frederik Damm, Willy Chan, Ralph Kettritz, Christopher Maximilian Arends, Anthony Rousselle, Uwe Eckardt
Publikováno v:
Rheumatology. 58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8391c496f6aec623cef06e30b6b4e6f4
https://doi.org/10.1093/rheumatology/kez057.046
https://doi.org/10.1093/rheumatology/kez057.046
Autor:
Raphael Hablesreiter, Kaja Hoyer, Wen-Chien Chou, Kenichi Yoshida, Arnold Ganser, Hwei-Fang Tien, Jih-Luh Tang, Willy Chan, Lars Bullinger, Olga Blau, Seishi Ogawa, Igor-Wolfgang Blau, Hsin-An Hou, Nils Waldhueter, Peter J. M. Valk, Michael Heuser, David C. Linch, Tomasz Zemojtel, Yuichi Shiraishi, Piroska Klement, Felicitas Thol, Yusuke Shiozawa, Friederike Christen, Robert Kerrin Hills, Yotaro Ochi, Frederik Damm, Rosemary E. Gale, Bob Löwenberg
Publikováno v:
Blood, 133(10), 1140-1151. American Society of Hematology
Acute myeloid leukemia with t(8;21)(q22;q22) is characterized by considerable clinical and biological heterogeneity leading to relapse in up to 40% of patients. We sequenced coding regions or hotspot areas of 66 recurrently mutated genes in a cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ecc36ebc137e0b24ed56612bd19500
https://pubmed.ncbi.nlm.nih.gov/30846508
https://pubmed.ncbi.nlm.nih.gov/30846508
Autor:
Nils Waldhueter, Adrian Schreiber, Helga Fleischer-Notter, Tomasz Zemojtel, Sven Märdian, Mareike Frick, Kaja Hoyer, Marianne Sinn, Seishi Ogawa, Friederike Christen, Annegret Kunitz, Uwe Pelzer, Lars Bullinger, Frederik Damm, Ulrike Krüger, Kenichi Yoshida, Joel Galan-Sousa, Willy Chan, Daniel Noerenberg, Marten Jäger, Clemens A. Schmitt, Elena Mylonas, Bernd Dörken, Ricarda Seemann, Christopher Maximilian Arends
Publikováno v:
Leukemia. 32(9)
Clonal hematopoiesis of indeterminate potential (CHIP) occurs in an age-related manner and associates with an increased risk of hematologic cancer, atherosclerotic disease, and shorter overall survival. Little is known about the cell of origin, repar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4909fd43625604c43a7af01d0061a024
https://pubmed.ncbi.nlm.nih.gov/29491455
https://pubmed.ncbi.nlm.nih.gov/29491455