Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kaja Borup Løvschall"'
Autor:
Ane Bretschneider Søgaard, Andreas Bøtker Pedersen, Kaja Borup Løvschall, Pere Monge, Josefine Hammer Jakobsen, Leila Džabbarova, Line Friis Nielsen, Sandra Stevanovic, Raoul Walther, Alexander N. Zelikin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Transmembrane signaling is the core adaptation in nature that allows cells to communicate. Here, the authors engineer signaling through the lipid bilayer using chemical, synthetic receptors for their use in the design of artificial cells.
Externí odkaz:
https://doaj.org/article/d9661349c54041f0b7cda27311cb5580
Autor:
Mireia Casanovas Montasell, Pere Monge, Sheiliza Carmali, Livia Mesquita Dias Loiola, Dante Guldbrandsen Andersen, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Maria Merrild Kristensen, Jean Maurice Pütz, Alexander N. Zelikin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Reversible on/off switches for enzyme activity are foundational in nature but are challenging to design using tools of synthetic chemistry. Here the authors design chemical zymogens amenable for activation via biomolecular interactions.
Externí odkaz:
https://doaj.org/article/f86f49355a604cf09148fd650aea7473
Autor:
Rüdiger Groß, Lívia Mesquita Dias Loiola, Leila Issmail, Nadja Uhlig, Valentina Eberlein, Carina Conzelmann, Lia‐Raluca Olari, Lena Rauch, Jan Lawrenz, Tatjana Weil, Janis A. Müller, Mateus Borba Cardoso, Andrea Gilg, Olivia Larsson, Urban Höglund, Sandra Axberg Pålsson, Anna Selch Tvilum, Kaja Borup Løvschall, Maria M. Kristensen, Anna‐Lena Spetz, Fortune Hontonnou, Marie Galloux, Thomas Grunwald, Alexander N. Zelikin, Jan Münch
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhi
Externí odkaz:
https://doaj.org/article/efb36e92da2449a5bac3fba657c93ca6
Autor:
Pere Monge, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Raoul Walther, Thaddeus W. Golbek, Lars Schmüser, Tobias Weidner, Alexander N. Zelikin
Publikováno v:
Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)
Abstract The design of a fully synthetic, chemical “apoptosis‐inducing receptor” (AIR) molecule is reported that is anchored into the lipid bilayer of cells, is activated by the incoming biological input, and responds with the release of a seco
Externí odkaz:
https://doaj.org/article/62c06663a1c0469096a0338d5d42740e
Autor:
Pere Monge, Anne Tvilum, Ane Bretschneider Søgaard, Kaja Borup Løvschall, Morten T. Jarlstad Olesen, Alexander N. Zelikin
Publikováno v:
Advanced Science, Vol 7, Iss 18, Pp n/a-n/a (2020)
Abstract The newest generation of cell‐based technologies relies heavily on methods to communicate to the engineered cells using artificial receptors, specifically to deactivate the cells administered to a patient in the event of adverse effects. H
Externí odkaz:
https://doaj.org/article/60838a236f924969a9b1ba8983753d9e
Autor:
Pere Monge, Maria Kristensen, Sheiliza Carmali, Kaja Borup Løvschall, Mireia Montasell, Ane Bretschneider Søgaard, Jean-Maurice Pütz, Livia Loiola, Dante Guldbrandsen Andersen, Alexander N. Zelikin
Chemical zymogens of three different types were established herein around protein cysteinome, in each case converting the protein thiol into a disulfide linkage: zero length Z0, polyethylene glycol based ZPEG, and ZLA that features a fast-depolymeriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc08e4ba088ea582d507301da3e1c244
https://doi.org/10.1101/2021.07.25.453687
https://doi.org/10.1101/2021.07.25.453687
Autor:
Kaja Borup Løvschall, Raoul Walther, Pere Monge, Sandra Stevanovic, Alexander N. Zelikin, Line D. F. Nielsen
Signal transduction through sealed biological membranes is among the most important evolutionary achievements. Herein, we focus on the development of artificial signal transduction mechanisms and engineer a bionic receptor with capacity of transducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04989c4005fb2b52362ea11a34d9683
https://doi.org/10.1101/2021.07.25.453684
https://doi.org/10.1101/2021.07.25.453684
Autor:
Mireia Casanovas Montasell, Pere Monge, Sheiliza Carmali, Livia Mesquita Dias Loiola, Dante Guldbrandsen Andersen, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Maria Merrild Kristensen, Jean Maurice Pütz, Alexander N. Zelikin
Publikováno v:
Montasell, M C, Monge, P, Carmali, S, Loiola, L M D, Andersen, D G, Løvschall, K B, Søgaard, A B, Kristensen, M M, Pütz, J M & Zelikin, A N 2022, ' Chemical zymogens for the protein cysteinome ', Nature Communications, vol. 13, 4861 . https://doi.org/10.1038/s41467-022-32609-1
Montasell, M C, Monge, P, Carmali, S, Dias Loiola, L M, Andersen, D G, Løvschall, K B, Søgaard, A B, Kristensen, M M, Pütz, J M & Zelikin, A N 2022, ' Chemical zymogens for the protein cysteinome ', Nature Communications, vol. 13, no. 1, 4861 . https://doi.org/10.1038/s41467-022-32609-1
Montasell, M C, Monge, P, Carmali, S, Dias Loiola, L M, Andersen, D G, Løvschall, K B, Søgaard, A B, Kristensen, M M, Pütz, J M & Zelikin, A N 2022, ' Chemical zymogens for the protein cysteinome ', Nature Communications, vol. 13, no. 1, 4861 . https://doi.org/10.1038/s41467-022-32609-1
We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast-depolymerizing fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4e65646886a13fea642fa1f735dc80
https://pubmed.ncbi.nlm.nih.gov/35982075
https://pubmed.ncbi.nlm.nih.gov/35982075
Autor:
Alexander N. Zelikin, Marcelo Ganzarolli de Oliveira, Leonardo P. Giglio, Kaja Borup Løvschall, Guilherme F. Picheth
Publikováno v:
Giglio, L P, Picheth, G F, Løvschall, K B, Zelikin, A N & de Oliveira, M G 2020, ' S-nitrosothiol-terminated poly(vinyl alcohol) : Nitric oxide release and skin blood flow response ', Nitric Oxide-Biology and Chemistry, vol. 98, pp. 41-49 . https://doi.org/10.1016/j.niox.2020.03.002
Polymeric biomaterials capable of delivering nitric oxide (NO) topically can be used to enhance skin blood flow (SkBF) and accelerate wound healing. Herein, we used reversible addition-fragmentation chain transfer radical (RAFT) polymerization to syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501e17fda64dfa976858ff5870b8426
https://pubmed.ncbi.nlm.nih.gov/32147583
https://pubmed.ncbi.nlm.nih.gov/32147583
Autor:
Lise L. Sørensen, Camilla Frich Riber, Alexander N. Zelikin, Paulina Gajda, Martin Tolstrup, Anna H. F. Andersen, Kaja Borup Løvschall, Kaja Zuwala
Publikováno v:
Journal of Controlled Release
Riber, C F, Zuwala, K, Løvschall, K, Andersen, A H F, Sørensen, L, Gajda, P, Tolstrup, M & Zelikin, A N 2018, ' Macromolecular prodrugs of ribavirin : Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects ', Journal of Controlled Release, vol. 275, no. April, pp. 53-66 . https://doi.org/10.1016/j.jconrel.2018.02.012
Riber, C F, Zuwala, K, Løvschall, K, Andersen, A H F, Sørensen, L, Gajda, P, Tolstrup, M & Zelikin, A N 2018, ' Macromolecular prodrugs of ribavirin : Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects ', Journal of Controlled Release, vol. 275, no. April, pp. 53-66 . https://doi.org/10.1016/j.jconrel.2018.02.012
Macromolecular (pro)drugs hold much promise as broad-spectrum antiviral agents as either microbicides or carriers for intracellular delivery of antiviral drugs. Intriguing opportunity exists in combining the two modes of antiviral activity in the sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d1b0fcfad603e39dc75ed2ab14fcf2
http://europepmc.org/articles/PMC7114659
http://europepmc.org/articles/PMC7114659