Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection

Autor: Jessica R. Chaffey, Jay Young, Kaiyven A. Leslie, Katie Partridge, Pouria Akhbari, Shalinee Dhayal, Jessica L. Hill, Kyle C. A. Wedgwood, Edward Burnett, Mark A. Russell, Sarah J. Richardson, Noel G. Morgan

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract The generation of a human pancreatic beta cell line which reproduces the responses seen in primary beta cells, but is amenable to propagation in culture, has long been an important goal in diabetes research. This is particularly true for stu

Externí odkaz: https://doaj.org/article/2b039b3f52724d06b5086c5235906f58

Mortality and its determinants in antiretroviral treatment-naive HIV-infected children with suspected tuberculosis: an observational cohort study

Autor: Ay, Sao Sarady, Borand, Laurence, Chan, Malen, Chea, Phalla, Dim, Bunnet, Goyet, Sophie, Marcy, Olivier, Men, Nimul Roat, Pheng, Phearavin, Ramsay, Susan, Suom, Sophea, Tarantola, Arnaud, Te, Naisim, Than, Sreymom, Ung, Sovannary, Chhuk, Chorn, Huot, Chantheany, Kath, Sang Han, Khin, Sokoeun, Kim, Peou, Lim, Kim Eng, Lim, Phary, Lim, Vannareth, Nav, Yany, Pich, Boren, Tuy, Sotharin, Ung, Vibol, Chea, Phal, Chhraing, Sengtray, Chuop, Bophal, Hem, Ramy, Heng, Phanoeurn, Huon, Seng Hap, Khum, Sokhorn, Liv, Thear, Ly, Vichea, Moch, Makara, Neou, Leakheana, Rey, Phanith, Sath, Vina, Sun, Nopheavann, Chat, Pheron, Srey, Viso, Chheang, Sitha, Hor, Putchhat, Oum, Manory, Keo, Monorea, Kou, Sokchea, Cheng, Sokleaph, Kerleguer, Alexandra, Gomgnimbou, Michel, Kabore, Antoinette, Millogo, Anselme, Nacro, Boubacar, Nikiema, Zakari, Ouedraogo, Abdul Salam, Saidou, Sawadogo, Nouctara, Moumini, Sangare/Ouattara, Diane Ursule, Sanogo, Bintou, Sib Sié, Edgard, Zingué, Dézémon, Abiguide, Roger Ngoya, Assene Ngo'o, Patrice, Ateba Ndongo, Francis, Balla, Suzanne, Bolyse Mbouchong, Verlaine, Ehongo Amanya, Jean Marie, Eyangoh, Sara, Kaiyven, Afi Leslie, Koki Ndombo, Paul, Kokola Bayanak, Samuel Walter, Mapah Kampaing, Marie Josée, Mangoya, Elizabeth, Mvogo, Minkala, Ndongo, Jean Pierre, Ngassam, Laurence, Nanda, Francine, Ndjantou, Sylviane, Ndongo, Jean Audrey, Njind Nkoum, Marcelle, Njom Lend, Anne Esther, Nkembe, Angeline, Oyanche, Marie Flore, Taguebue, Jean-Voisin, Tejiokem, Mathurin, Tetang-Moyo, Suzy, Zebaze, Sylvie Georgette, Nguyen, Thi Oanh, Nguyen, Thi Ngoc Lan, Quillet, Catherine, Quoc, Khanh Lê, To, My Huong, Tran, Thi Kim Phung, Do, Chau Giang, Nguyen, Duc Bang, Nguyen, Ngo Vi Vi, Nguyen, Thi Hieu, Nguyen, Thi Thanh Thanh, Tran, Ngoc Duong, Vo, Duy An, Dang, Thi Xuan Lan, Do, Thi Kim Phuong, Dang, Thi Thanh Tuyen, Nguyen, Hoang Chau, Pham, Ngoc Tuong Vy, Truong, Huu Khanh, Do, Chau Viet, Huynh, Bich Ngoc, Le, Thi Thanh Thuy, Nguyen, Thi Thu Hiep, Tran, Ngoc Luu, Vu, Thien An, Tran, Huu Loc, Nguyen, Manh Hoang, Nguyen, Ngoc Lan, Van Nguyen, Thi Cao, Pham, Thu Hang, Phan, Dinh Quyen, Vo, Thi Ha, Truong, Xuan Lien, Vu, Xuan Thinh, Blanche, Stéphane, Delacourt, Christophe, Berteloot, Laureline, Carcelain, Guislaine, Godreuil, Sylvain, Fournier-Nicolle, Isabelle, Msellati, Philippe, Truong Huu, Khanh, Do Chau, Viet, Tran Ngoc, Duong, Ateba-Ndongo, Francis, Tetang-Ndiang, Suzie, Neou, Leakhena

Publikováno v: In The Lancet HIV February 2018 5(2):e87-e95

Trypan Blue Exclusion Assay, Neutral Red, Acridine Orange and Propidium Iodide

Autor: Arinzechukwu Ude, Kaiyven Afi-Leslie, Kelechi Okeke, Emmanuel Ogbodo

Cytotoxicity and cell viability assessments are very important parameters that are widely used in fundamental research and drug development to determine the safety profile of toxic compounds. These assays measure the degree to which a substance can c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e8b84c07d57d2471c9f3ced242764f
https://mts.intechopen.com/articles/show/title/trypan-blue-exclusion-assay-neutral-red-acridine-orange-and-propidium-iodide

Expression of CD47 in the pancreatic β‐cells of people with recent‐onset type 1 diabetes varies according to disease endotype

Autor: Mark Russell, Noel G. Morgan, Sarah J. Richardson, Kaiyven A. Leslie

Publikováno v: Diabetic Medicine. 38

Aims We are studying the dialogue between β-cells and the immune system in type 1 diabetes and have identified a cell surface receptor, Signal Regulatory Protein-alpha (SIRPα) as an important component in the regulation of β-cell survival. SIRPα

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69e9deaabae818930744b5e65287483
https://doi.org/10.1111/dme.14724

Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death

Autor: Noel G. Morgan, Hannah J. Welters, Kaiyven A. Leslie, Patricia Thomas

Publikováno v: Nutrition & Metabolism
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-7 (2021)

Obesity is a major risk factor for type 2 diabetes (T2D) although the causal links remain unclear. A feature shared by both conditions however is systemic inflammation and raised levels of circulating fatty acids (FFA). It is widely believed that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26623919810f40a5b77f28fa1e0728b3
http://europepmc.org/articles/PMC7802137