Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

Autor: Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Cyrus Khandanpour

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A single nucleotide polymorphism of GFI1, GFI1-36N, has a prevalence of 7% in healthy Caucasians

Externí odkaz: https://doaj.org/article/c5c15658eeb2484f8e743eefeb882967

LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis

Autor: Jie Chu, Hongle Li, Yurong Xing, Jinlin Jia, Jinxiu Sheng, Lijun Yang, Kaiyan Sun, Yunhui Qu, Yan Zhang, Huiqing Yin, Junhu Wan, Fucheng He

Publikováno v: Biomedicine & Pharmacotherapy, Vol 116, Iss , Pp 109029- (2019)

Background: Long non-coding RNAs (lncRNAs) are powerful factors influencing the tumorigenesis and metastasis of multiple carcinomas. LncRNA MNX1-AS1 plays critical roles in the progression of tumor formation according to recent research, while its ro

Externí odkaz: https://doaj.org/article/93eee92d875c444385658c47627e80ee

Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple Myeloma

Autor: Kaiyan Sun, Ling Jin, Jana Karolová, Jan Vorwerk, Stephan Hailfinger, Bertram Opalka, Myroslav Zapukhlyak, Georg Lenz, Cyrus Khandanpour

Publikováno v: Cancers; Volume 15; Issue 8; Pages: 2373

Multiple myeloma (MM) is an incurable, malignant B cell disorder characterized by frequent relapses and a poor prognosis. Thus, new therapeutic approaches are warranted. The phosphatidylinositol-3-kinase (PI3K) pathway plays a key role in many critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce67be0f5f11d09b222ecd292dcf519
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85153955325

DNA targeting by subtype I-D CRISPR–Cas shows type I and type III features

Autor: Jinzhong Lin, Anders Fuglsang, Xu Peng, Anders L. Kjeldsen, Kaiyan Sun, Yuvaraj Bhoobalan-Chitty

Publikováno v: Lin, J, Fuglsang, A, Kjeldsen, A L, Sun, K, Bhoobalan-Chitty, Y & Peng, X 2020, ' DNA targeting by subtype I-D CRISPR-Cas shows type I and type III features ', Nucleic Acids Research, vol. 48, no. 18, pp. 10470-10478 . https://doi.org/10.1093/nar/gkaa749
Nucleic Acids Research

Prokaryotic CRISPR–Cas immune systems are classified into six types based on their effector complexes which cleave dsDNA specifically (types I, II and V), ssRNA exclusively (type VI) or both ssRNA via a ruler mechanism and ssDNA unspecifically (typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84687900ed3ea9a98a6fa6d9fca000be
https://doi.org/10.1093/nar/gkaa749

Targeting PI3K-AKT-mTOR Signaling in Multiple Myeloma Mesenchymal Stem Cells Mediates Antiproliferative Effect on Myeloma Cells

Autor: Helal Mohammed Mohammed Ahmed Noman, Georg Lenz, Cyrus Khandanpour, Lanying Wei, Subbaiah Chary Nimmagadda, Kaiyan Sun, Hanna Korab, Marc-Steffen Raab, Luca Heinmann, Alexandra M Poos, Daria Frank, Anja Baumann, Klara Möllers

Publikováno v: Blood. 138:1600-1600

Introduction: Multiple myeloma (MM) is a B-cell malignancy characterized by an abnormal proliferation and infiltration of malignant plasma cells in the bone marrow (BM). Mesenchymal stromal cells (MSCs) represent a crucial component of the BM niche a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f536dcd2047988167313e17d0e0de9e0
https://doi.org/10.1182/blood-2021-150413