Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kaiwen W. Chen"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-8 (2024)
Abstract TLR4 and TNFR1 signalling promotes potent proinflammatory signal transduction events, thus, are often hijacked by pathogenic microorganisms. We recently reported that myeloid cells retaliate Yersinia blockade of TAK1/IKK signalling by trigge
Externí odkaz:
https://doaj.org/article/1c84a5e3d9f243af859538a0387877e6
Autor:
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-12 (2024)
Abstract Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious d
Externí odkaz:
https://doaj.org/article/62a57fe64f944d87ab3862e5bd598553
Autor:
José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation.
Externí odkaz:
https://doaj.org/article/6cea1f719e794133aac06f44406b21f2
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to r
Externí odkaz:
https://doaj.org/article/f5a94d40bfec4623b6af5d4b169217aa
Autor:
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms
Externí odkaz:
https://doaj.org/article/a43be258b327448fa6e72d48bc208d26
Autor:
Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine Hall, Angelina J. Vince, Simon M. Chatfield, Damian B. D’Silva, Kenneth C. Pang, Kate Schroder, John Silke, David L. Vaux, Philipp J. Jost, James E. Vince
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 668-682 (2017)
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP
Externí odkaz:
https://doaj.org/article/b2bf45d4cadc4d619c18b1853295fdda
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is requi
Externí odkaz:
https://doaj.org/article/e9430d2c982c4d82bc574308f8b9cb89
Autor:
Kaiwen W. Chen, Christina J. Groß, Flor Vásquez Sotomayor, Katryn J. Stacey, Jurg Tschopp, Matthew J. Sweet, Kate Schroder
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 570-582 (2014)
The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contrib
Externí odkaz:
https://doaj.org/article/f74eadcc92da400482d6b2afcb497393
Autor:
Hui Wen Yeap, Kaiwen W. Chen
Publikováno v:
Biochemical Society Transactions. 50:1583-1594
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by eit
Autor:
Felicia Hui Min Chan, Kaiwen W. Chen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7bd84fc00809891ef22f5744ecd876
https://doi.org/10.1007/978-1-0716-3040-2_9
https://doi.org/10.1007/978-1-0716-3040-2_9