Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kaiwen W Chen"'
Autor:
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-8 (2024)
Abstract TLR4 and TNFR1 signalling promotes potent proinflammatory signal transduction events, thus, are often hijacked by pathogenic microorganisms. We recently reported that myeloid cells retaliate Yersinia blockade of TAK1/IKK signalling by trigge
Externí odkaz:
https://doaj.org/article/1c84a5e3d9f243af859538a0387877e6
Autor:
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-12 (2024)
Abstract Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious d
Externí odkaz:
https://doaj.org/article/62a57fe64f944d87ab3862e5bd598553
Autor:
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms
Externí odkaz:
https://doaj.org/article/a43be258b327448fa6e72d48bc208d26
Autor:
Hui Wen Yeap, Kaiwen W. Chen
Publikováno v:
Biochemical Society Transactions. 50:1583-1594
Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a02a8b956baed95f185e365f9cad2d
https://doi.org/10.1042/bst20211242
https://doi.org/10.1042/bst20211242
Autor:
Kate E. Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A. Conos, Kaiwen W. Chen, Stephanie Ziehe, Carina Graß, Yifan Zhan, Tan A. Nguyen, Cathrine Hall, Angelina J. Vince, Simon M. Chatfield, Damian B. D’Silva, Kenneth C. Pang, Kate Schroder, John Silke, David L. Vaux, Philipp J. Jost, James E. Vince
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 668-682 (2017)
X-linked Inhibitor of Apoptosis (XIAP) deficiency predisposes people to pathogen-associated hyperinflammation. Upon XIAP loss, Toll-like receptor (TLR) ligation triggers RIPK3-caspase-8-mediated IL-1β activation and death in myeloid cells. How XIAP
Externí odkaz:
https://doaj.org/article/b2bf45d4cadc4d619c18b1853295fdda
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 4 (2019)
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is requi
Externí odkaz:
https://doaj.org/article/e9430d2c982c4d82bc574308f8b9cb89
Autor:
Felicia Hui Min Chan, Kaiwen W. Chen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7bd84fc00809891ef22f5744ecd876
https://doi.org/10.1007/978-1-0716-3040-2_9
https://doi.org/10.1007/978-1-0716-3040-2_9
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation
Autor:
Kaiwen W Chen
Publikováno v:
EMBO reports. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad7a3098e60b71f4701171553f9053f
https://doi.org/10.15252/embr.202256091
https://doi.org/10.15252/embr.202256091
Autor:
Kaiwen W Chen, Igor E Brodsky
Publikováno v:
Current opinion in microbiology. 71
Cell death in response to infection is conserved across all kingdoms of life. In metazoans, cell death upon bacterial infection is primarily carried out by the cysteine and aspartate protease and receptor-interacting serine/threonine protein kinase f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed7c72ccc58a522233883c16f56baef
https://pubmed.ncbi.nlm.nih.gov/36584489
https://pubmed.ncbi.nlm.nih.gov/36584489