Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kaito Shibata"'
Autor:
Takashi Mochizuki, Kaito Shibata, Takafumi Naito, Kumiko Shimoyama, Noriyoshi Ogawa, Masato Maekawa, Junichi Kawakami
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 6, Pp 852-859 (2022)
The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry (LC-MS/MS) method has not been widely applied in clinical settings because of its time-consuming and costly sample pretreatments. The present study aimed to de
Externí odkaz:
https://doaj.org/article/8b7901ed260f47128a86c5891a0ca7bd
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:481-490
Autor:
Atsushi Otsuka, Junichi Kawakami, Masato Karayama, Kazuki Abe, Masato Maekawa, Kaito Shibata, Takafumi Naito, Hideaki Miyake, Takafumi Suda
Publikováno v:
European Journal of Clinical Pharmacology. 78:77-87
Serum nivolumab concentrations exhibit a large variation in cancer patients. Cancer cachexia inducing systemic inflammation promotes the elimination of endogenous proteins, while its association with serum nivolumab remains unclear. The present study
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
Long-term use of itraconazole (ITZ) is associated with a risk of inducing hepatotoxicity. This study aimed to evaluate the associations of plasma concentrations of ITZ and its hydroxylated metabolite (OH-ITZ) with endogenous markers of hepatic functi
Oral aprepitant has a large interindividual variation in clinical responses in advanced cancer. This study aimed to characterize plasma aprepitant and its N-dealkylated metabolite (ND-AP) based on the cachexia progression and clinical responses in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6a59a2fa381c2930a90d1189b369ac
https://doi.org/10.21203/rs.3.rs-1959940/v1
https://doi.org/10.21203/rs.3.rs-1959940/v1
Autor:
Kaito Shibata, Junichi Kawakami, Satoshi Hirakawa, Hiroyuki Mineta, Seiji Hosokawa, Koji Suzuki, Takafumi Naito
Publikováno v:
Cancer Chemotherapy and Pharmacology. 87(4):555-565
Purpose: Cetuximab inhibits epidermal growth factor receptor (EGFR) signaling in cancer and skin cells, thereby inducing anti-cancer effects and skin disorders. The present study aimed to evaluate the relationships between serum cetuximab and EGFR-re
Autor:
Koji Suzuki, Yasuhide Yamada, Takafumi Naito, Kaito Shibata, Kunihiko Itoh, Junichi Kawakami, Hironari Tanaka
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:472-481
This study aimed to evaluate the influence of CYP2D6 activity and cachexia progression on the enantiomeric alteration of plasma tramadol and its demethylated metabolites in head and neck cancer patients. Fifty-three head and neck cancer patients rece
Autor:
Kazuki Abe, Takafumi Suda, Junichi Kawakami, Etsuko Hamada, Masato Maekawa, Masato Karayama, Takafumi Naito, Kaito Shibata, Yasuhide Yamada
Publikováno v:
Analytical Methods. 12:54-62
A liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method is a novel approach for the quantification of therapeutic monoclonal antibody. However, this method has severe ionization suppression and time-consuming sample preparation.
Autor:
Kazuki, Abe, Kaito, Shibata, Takafumi, Naito, Atsushi, Otsuka, Masato, Karayama, Masato, Maekawa, Hideaki, Miyake, Takafumi, Suda, Junichi, Kawakami
Publikováno v:
European journal of clinical pharmacology. 78(1)
Serum nivolumab concentrations exhibit a large variation in cancer patients. Cancer cachexia inducing systemic inflammation promotes the elimination of endogenous proteins, while its association with serum nivolumab remains unclear. The present study
Publikováno v:
Therapeutic Drug Monitoring.
BACKGROUND Aprepitant, an antiemetic selective neurokinin-1 receptor antagonist, is primarily metabolized to the active N-dealkylated form (ND-AP) and then converted to its carbonyl form (ND-CAP) in humans. This study developed a simple liquid chroma