Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kaitlyn M. Morabito"'
Autor:
Sara E. Woodson, Kaitlyn M. Morabito
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-8 (2024)
The 2016 Zika virus (ZIKV) epidemic catalyzed a global effort to develop diagnostic tests, vaccines, and therapeutic treatments. However, the rapid waning epidemiology of ZIKV stalled many countermeasure development efforts. On January 31 and Februar
Externí odkaz:
https://doaj.org/article/6f1047bfcb35415e9c121cf1d53ab08a
Autor:
Brooke Bollman, Naveen Nunna, Kapil Bahl, Chiaowen Joyce Hsiao, Hamilton Bennett, Scott Butler, Bryant Foreman, Katherine E. Burgomaster, Maya Aleshnick, Wing-Pui Kong, Brian E. Fisher, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Barney S. Graham, Kimberly A. Dowd, Theodore C. Pierson, Andrea Carfi
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of congenital disease during a major outbreak in the Americas in 2016. Vaccine design strategies relied on limited available isolate sequence information du
Externí odkaz:
https://doaj.org/article/3c2c868a1a4e4f24a57b9b30508496ea
Autor:
Rebecca J. Loomis, Anthony T. DiPiazza, Samantha Falcone, Tracy J. Ruckwardt, Kaitlyn M. Morabito, Olubukola M. Abiona, Lauren A. Chang, Ria T. Caringal, Vladimir Presnyak, Elisabeth Narayanan, Yaroslav Tsybovsky, Deepika Nair, Geoffrey B. Hutchinson, Guillaume B. E. Stewart-Jones, Lisa A. Kueltzo, Sunny Himansu, John R. Mascola, Andrea Carfi, Barney S. Graham
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nipah virus (NiV) represents a significant pandemic threat with zoonotic transmission from bats-to-humans with almost annual regional outbreaks characterized by documented human-to-human transmission and high fatality rates. Currently, no vaccine aga
Externí odkaz:
https://doaj.org/article/1645dea2614f43f6baad4345b571338b
Autor:
Rebecca J. Loomis, Guillaume B. E. Stewart-Jones, Yaroslav Tsybovsky, Ria T. Caringal, Kaitlyn M. Morabito, Jason S. McLellan, Amy L. Chamberlain, Sean T. Nugent, Geoffrey B. Hutchinson, Lisa A. Kueltzo, John R. Mascola, Barney S. Graham
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Licensed vaccines or therapeutics are rarely available for pathogens with epidemic or pandemic potential. Developing interventions for specific pathogens and defining generalizable approaches for related pathogens is a global priority and inherent to
Externí odkaz:
https://doaj.org/article/a1bbbff82f3d4c11bf226a9b4c218342
Autor:
Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T. D. Nunes, Daniele B. A. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barrett, Scott C. Weaver, Shannan L. Rossi, Pedro F. C. Vasconcelos, Barney S. Graham, Michael S. Diamond, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Zika virus infection can result in congenital disorders and cause disease in adults, and there is currently no approved vaccine. Here Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis damage and transmis
Externí odkaz:
https://doaj.org/article/04efca35dcf0457db06e055dcc33fee4
Autor:
Kaitlyn M. Morabito, Tracy J. Ruckwardt, Erez Bar-Haim, Deepika Nair, Syed M. Moin, Alec J. Redwood, David A. Price, Barney S. Graham
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tissue-resident memory T (TRM) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, TRM cells protect against respiratory infections, but wane more quickly than TRM cells in other tissues. This lack
Externí odkaz:
https://doaj.org/article/c945c838557b41e79f92598e2bdcbe96
Autor:
Emily Phung, Lauren A. Chang, Kaitlyn M. Morabito, Masaru Kanekiyo, Man Chen, Deepika Nair, Azad Kumar, Grace L. Chen, Julie E. Ledgerwood, Barney S. Graham, Tracy J. Ruckwardt
Publikováno v:
Vaccines, Vol 7, Iss 1, p 23 (2019)
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fus
Externí odkaz:
https://doaj.org/article/f0f63836d3ed411b93eda73d51fa2a8a
Autor:
Sjanna B Besteman, Emily Phung, Henriette H M Raeven, Gimano D Amatngalim, Matevž Rumpret, Juliet Crabtree, Rutger M Schepp, Lisa W Rodenburg, Susanna G Siemonsma, Nile Verleur, Rianne van Slooten, Karen Duran, Gijs W van Haaften, Jeffrey M Beekman, Lauren A Chang, Linde Meyaard, Tjomme van der Bruggen, Guy A M Berbers, Nicole Derksen, Stefan Nierkens, Kaitlyn M Morabito, Tracy J Ruckwardt, Evelyn A Kurt-Jones, Douglas Golenbock, Barney S Graham, Louis J Bont
Publikováno v:
The Journal of Infectious Diseases. 226:258-269
Background Recurrent respiratory syncytial virus (RSV) infection requiring hospitalization is rare and the underlying mechanism is unknown. We aimed to determine the role of CD14-mediated immunity in the pathogenesis of recurrent RSV infection. Metho
Autor:
Lauren A. Chang, Emily Phung, Michelle C. Crank, Kaitlyn M. Morabito, Tonya Villafana, Filip Dubovsky, Judith Falloon, Mark T. Esser, Bob C. Lin, Grace L. Chen, Barney S. Graham, Tracy J. Ruckwardt
Publikováno v:
Science translational medicine. 14(676)
There is currently no licensed vaccine for respiratory syncytial virus (RSV). Here, we assess the effect of RSV fusion protein (F) conformation on B cell responses in a post hoc comparison of samples from the DS-Cav1 [prefusion (pre-F)] and MEDI7510
Autor:
Peifeng Chen, Anita Arthur, Kaitlyn M. Morabito, Kristin Leach, Xiaolin Wang, Grace L. Chen, Attila Nagy, Lauren A. Chang, Jon Cooper, Amy L. Chamberlain, Janel Holland-Linn, Olga Vasilenko, Alicia T. Widge, Shufeng Bai, Judith A Stein, LaSonji A. Holman, Cristina Carter, Iris Pittman, Deepika Gollapudi, Lisa A. Kueltzo, Colleen Fridley, Michelle C. Crank, Amritha Menon, William Whalen, Mridul Ghosh, Cynthia S. Hendel, Martha Nason, Amy Liu, Althaf Hussain, Laura Novik, Pernell Williams, Maria Burgos Florez, Robert T. Bailer, Thuy Nguyen, Brenda Larkin, Tracy J. Ruckwardt, Pamela Costner, Lam Le, Zhong Zhao, Elizabeth Carey, Vera Ivleva, Jennifer Walters, John R. Mascola, Jennifer Cunningham, Olga Trofymenko, Ya-chen Chang, Somia P. Hickman, Martin R. Gaudinski, Richard M. Schwartz, Slobodanka D. Manceva, Kevin Carlton, Barney S. Graham, Rahul Ragunathan, Jason G. D. Gall, Ana M. Ortega-Villa, Colin Tran, Sarah H. Plummer, Abidemi Ola, Ro Shauna S Rothwell, Ingelise J. Gordon, Mingzhong Chen, Jamie G. Saunders, Aba Mensima Eshun, Bob C. Lin, Azad Kumar, Nina M. Berkowitz, Xun Liu, Cora Trelles Cartagena, Emily Phung, Galina Yamshchikov, Joe Horwitz, Sarah O’Connell, Florence Kaltovich, Floreliz Mendoza, LaShawn Requilman, Man Chen, Preeti Apte, Christopher Lee, Renunda Hicks
Publikováno v:
Lancet Respir Med
Multiple active vaccination approaches have proven ineffective in reducing the substantial morbidity and mortality caused by respiratory syncytial virus (RSV) in infants and older adults (aged ≥65 years). A vaccine conferring a substantial and sust