Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kaitlyn Ho"'
Autor:
Erik C. B. Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E. Sanchez, Biljana Djukic, Isabel Lopez, Xinxing Yu, Michael Gill, Weiping Zhang, Jeanne T. Paz, Jorge J. Palop, Lennart Mucke
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-26 (2020)
Abstract Background Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain
Externí odkaz:
https://doaj.org/article/241e604b9e154d01b93f232dcc4d0aa4
Autor:
Melanie Das, Wenjie Mao, Eric Shao, Soniya Tamhankar, Gui-Qiu Yu, Xinxing Yu, Kaitlyn Ho, Xin Wang, Jiaming Wang, Lennart Mucke
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103245- (2021)
Summary: Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated. We suppress
Externí odkaz:
https://doaj.org/article/e869c5ad52c44f1d85777a893829f213
Autor:
Anna G. Orr, Iris Lo, Heike Schumacher, Kaitlyn Ho, Michael Gill, Weikun Guo, Daniel H. Kim, Anthony Knox, Takashi Saito, Takaomi C. Saido, Jeffrey Simms, Carlee Toddes, Xin Wang, Gui-Qiu Yu, Lennart Mucke
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 29-36 (2018)
Adenosine A2A receptors are putative therapeutic targets for neurological disorders. The adenosine A2A receptor antagonist istradefylline is approved in Japan for Parkinson's disease and is being tested in clinical trials for this condition elsewhere
Externí odkaz:
https://doaj.org/article/62158c22ffd34e74b78e39a026e12011
Autor:
Dena B. Dubal, Jennifer S. Yokoyama, Lei Zhu, Lauren Broestl, Kurtresha Worden, Dan Wang, Virginia E. Sturm, Daniel Kim, Eric Klein, Gui-Qiu Yu, Kaitlyn Ho, Kirsten E. Eilertson, Lei Yu, Makoto Kuro-o, Philip L. De Jager, Giovanni Coppola, Gary W. Small, David A. Bennett, Joel H. Kramer, Carmela R. Abraham, Bruce L. Miller, Lennart Mucke
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1065-1076 (2014)
Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the hu
Externí odkaz:
https://doaj.org/article/f7e79af4e7e64a0c94ccb77027792065
Autor:
Jason S Cheng, Ryan Craft, Gui-Qiu Yu, Kaitlyn Ho, Xin Wang, Geetha Mohan, Sergey Mangnitsky, Ravikumar Ponnusamy, Lennart Mucke
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115765 (2014)
Because reduction of the microtubule-associated protein Tau has beneficial effects in mouse models of Alzheimer's disease and epilepsy, we wanted to determine whether this strategy can also improve the outcome of mild traumatic brain injury (TBI).We
Externí odkaz:
https://doaj.org/article/3f8bafd223c74e54ba34339469d58765
Autor:
Julie A Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Mucke
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45881 (2012)
Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest pathological hallmarks in patients with Alzheimer's disease (AD). It can occur before significant Aβ deposition and appears to "spread" into anatomically co
Externí odkaz:
https://doaj.org/article/f8e15b3e38db4db0b14cf7b0ad584b67
Autor:
Jiaming Wang, Xinxing Yu, Lennart Mucke, Xin Wang, Kaitlyn Ho, Gui-Qiu Yu, Wenjie Mao, Soniya Tamhankar, Eric Shao, Melanie Das
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103245-(2021)
iScience, vol 24, iss 11
iScience
iScience, vol 24, iss 11
iScience
Summary Nonconvulsive epileptiform activity and microglial alterations have been detected in people with Alzheimer’s disease (AD) and related mouse models. However, the relationship between these abnormalities remains to be elucidated. We suppresse
Autor:
Xinxing Yu, Gui-Qiu Yu, Daniel Kim, Melanie Das, Eric Shao, Kaitlyn Ho, Weiping J. Zhang, Lennart Mucke, Daniel R. Gulbranson, Reuben Thomas, Krishna Choudhary
Publikováno v:
eNeuro
eNeuro, vol 8, iss 3
eNeuro, vol 8, iss 3
Diverse gene products contribute to the pathogenesis of Alzheimer’s disease (AD). Experimental models have helped elucidate their mechanisms and impact on brain functions. Human amyloid precursor protein (hAPP) transgenic mice from line J20 (hAPP-J
Autor:
Piatã Marques, Edina Illyes, Shannon McCauley, Donald A. Jackson, Diana Michalakos, Ilia Maria C. Ferzoco, Laura Timms, Rosalind L. Murray, Zira S. MacFarlane, Tim P. Duval, Rebecca Dolson, Sajjad Din, Dale Pebesma, Andrea E. Kirkwood, Nicole A. Turner, Jon Clayton, Kaitlyn Horton, Christine M. Boston, Ekaterina Sapozhnikova, Marc W. Cadotte, Nicholas E. Mandrak
Publikováno v:
Ecological Solutions and Evidence, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Urban stormwater management ponds (SWMPs) are widely employed for stormwater control, but knowledge about their contributions to urban ecosystem function and service delivery remains unclear. We organized a workshop that brought together res
Externí odkaz:
https://doaj.org/article/b07a486bf4d94e73a184216ef5872552
Autor:
Richard Furie, Judith A James, Maria Dall’Era, Michelle A Petri, Chaim Putterman, Peter Izmirly, Jill P Buyon, Diane L Kamen, Betty Diamond, David Wofsy, Soumya Raychaudhuri, Jennifer Grossman, Fan Zhang, Jun Inamo, Nir Hacohen, Alice Horisberger, Kenneth C Kalunian, Michael B Brenner, Mariko Ishimori, David Hildeman, Robert Clancy, ANNE DAVIDSON, Matthias Kretzler, Michael Weisman, Celine C Berthier, Andrea Fava, Takanori Sasaki, Jennifer L Barnas, Jennifer H Anolik, Paul J Hoover, Deepak A Rao, Joshua Keegan, James A Lederer, Joel Guthridge, Michael Belmont, Arnon Arazi, William Apruzzese, Fernanda Payan-Schober, Jeffrey Hodgin, Thomas M Eisenhaure, Steve Woodle, Maureen A McMahon, Ekaterina Murzin, Katie Preisinger, Alec Griffith, Kaitlyn Howard, Tusharkanti Ghosh, Rebecca Beuschel, John Pulford, Brandon Hancock, Maria Gutierrez-Arcelus
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/af7a6997976c427eb75e9753159ca89f