Výsledky vyhledávání - "Kaitlyn E. Coil"

Structure–activity relationships of methyl-lysine reader antagonists

Autor: Lindsey I. James, J. Martin Herold, Peter Brown, Jacqueline L. Norris, Cen Gao, Kaitlyn E. Coil, Dennis J. Bua, Victoria K. Korboukh, Stephen V. Frye, Or Gozani, William P. Janzen, Dmitri Kireev, Jian Jin

Publikováno v: MedChemComm. 3:45-51

The interaction between methyl-lysine binding proteins and methylated histones plays a crucial role in the regulation of gene expression. Herein we describe the development of structure–activity relationships (SAR) surrounding UNC669, the first rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d356c56b2a462dffc1080544488769
https://doi.org/10.1039/c1md00195g

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The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

Autor: Eric G. Folco, Robin Reed, Kaitlyn E. Coil

Publikováno v: Genes & Development. 25:440-444

Duplex formation between the branch point-binding region (BBR) of U2 snRNA and the branch point sequence (BPS) in the intron is essential for splicing. Both the BBR and BPS interact with the U2 small nuclear ribonucleoprotein (snRNP)-associated SF3b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da637062dae2f8e4aa48974771e96660
https://doi.org/10.1101/gad.2009411

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