Výsledky vyhledávání - "Kaitlyn E Redford"

Akademický článek

KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

Autor: Geoffrey W. Abbott, Kaitlyn E. Redford, Ryan F. Yoshimura, Rían W. Manville, Luiz Moreira, Kevin Tran, Grey Arena, Alexandra Kookootsedes, Emma Lasky, Elliot Gunnison

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant metabolites. Here, we screened methanolic extracts prepared from 40 Cali

Externí odkaz: https://doaj.org/article/1d88ec059d934e06b7925c86bbc4cd3d

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KCNQ Potassium Channels as Targets of Botanical Folk Medicines

Autor: Geoffrey W. Abbott, Kaitlyn E Redford

Publikováno v: Annu Rev Pharmacol Toxicol

Since prehistory, human species have depended on plants for both food and medicine. Even in countries with ready access to modern medicines, alternative treatments are still highly regarded and commonly used. Unlike modern pharmaceuticals, many botan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c19c214e03bc8927bc6255754b2b99f
https://doi.org/10.1146/annurev-pharmtox-052120-104249

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KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine

Autor: Rían W. Manville, Kaitlyn E. Redford, Jennifer van der Horst, Derk J. Hogenkamp, Thomas A. Jepps, Geoffrey W. Abbott

Publikováno v: Manville, R W, Redford, K E, van der Horst, J, Hogenkamp, D J, Jepps, T A & Abbott, G W 2022, ' KCNQ5 activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine ', FASEB Journal, vol. 36, no. 9, e22457 . https://doi.org/10.1096/fj.202200724R

Tree and shrub barks have been used as folk medicine by numerous cultures across the globe for millennia, for a variety of indications, including as vasorelaxants and antispasmodics. Here, using electrophysiology and myography, we discovered that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6da7ae21fdba99900a0a522842ae8a
https://pubmed.ncbi.nlm.nih.gov/35997997

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KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea

Autor: Thomas A. Jepps, Kaitlyn E Redford, Geoffrey W. Abbott, Salomé Rognant

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cellular Physiology and Biochemistry, vol 55, iss S3
Cellular Physiology and Biochemistry, Vol 55, Iss S3, Pp 46-64 (2021)
Redford, K E, Rognant, S, Jepps, T A & Abbott, G W 2021, ' KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea ', Cellular Physiology and Biochemistry, vol. 55, no. S3, pp. 46-64 . https://doi.org/10.33594/000000337

BACKGROUND/AIMS: Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afc8c23103610cf0064248701e38dee
http://europepmc.org/articles/PMC8612027

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The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator

Autor: Geoffrey W. Abbott, Kaitlyn E Redford

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Communications biology, vol 3, iss 1
Communications Biology

Many commonly consumed plants are used as folk medicines, often with unclear molecular mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of voltage-gated potassium (Kv) channels as a therapeutic target for several medici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22de8296825678d7e149e90328cd703
http://link.springer.com/article/10.1038/s42003-020-1089-8

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KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics

Autor: Alexandra Kookootsedes, Kaitlyn E Redford, Kevin Tran, Rían W. Manville, Emma Lasky, Geoffrey W. Abbott, Grey Arena, Elliot Gunnison, Ryan F. Yoshimura, Luiz Moreira

Publikováno v: Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643ff23944921acbff22c6ea7a985945
https://doi.org/10.3389/fphys.2021.777057

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KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines

Autor: Geoffrey W. Abbott, Thomas A. Jepps, Jennifer van der Horst, Benjamin B. Katz, Rían W. Manville, Kaitlyn E Redford

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(42)

Botanical folk medicines have been used throughout human history to treat common disorders such as hypertension, often with unknown underlying mechanisms. Here, we discovered that hypotensive folk medicines from a genetically diverse range of plant s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df0f8e9a8a1e0a78755f7d7708e7da1
https://pubmed.ncbi.nlm.nih.gov/31570602

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Survival of Anaerobic Fe 2+ Stress Requires the ClpXP Protease

Autor: Jeffrey A. Gralnick, Brittany D. Bennett, Kaitlyn E. Redford

Publikováno v: Journal of Bacteriology. 200

Shewanella oneidensis strain MR-1 is a versatile bacterium capable of respiring extracellular, insoluble ferric oxide minerals under anaerobic conditions. The respiration of iron minerals results in the production of soluble ferrous ions, which at hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e280d9a647eb7022593df92904330b03
https://doi.org/10.1128/jb.00671-17

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MgtE Homolog FicI Acts as a Secondary Ferrous Iron Importer in Shewanella oneidensis Strain MR-1

Autor: Brittany D. Bennett, Jeffrey A. Gralnick, Kaitlyn E. Redford

Publikováno v: Applied and Environmental Microbiology. 84

The transport of metals into and out of cells is necessary for the maintenance of appropriate intracellular concentrations. Metals are needed for incorporation into metalloproteins but become toxic at higher concentrations. Many metal transport prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d56546d43987bcb66f3395bd33b0b2
https://doi.org/10.1128/aem.01245-17

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