Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kaitlyn E, Eckert"'
1
Polyphenols from the sagebrush
Autor: Carolyn Y, Dadabay, Paula Barrientos, Spaulding, Erick, Valenzuela, Matthew, Turner, Kaitlyn E, Eckert, Riitta, Julkunen-Tiitto, Nedra, Noblit, Donald H, Mansfield
Publikováno v: Curr Top Phytochem
Basin big sagebrush (Artemisia tridentata Nutt. ssp. tridentata (Asteraceae)), is a widespread North American shrub which produces a variety of polyphenolic compounds. Although sagebrush has been used as a traditional remedy by natives and settlers t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::845bdd48a71bc996d53404cbc816d0d5
https://pubmed.ncbi.nlm.nih.gov/35800213
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3
Rational Design and Identification of Harmine-Inspired, N-Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System
Autor: Francisco J. Huizar, Harrison M. Hill, Emily P. Bacher, Kaitlyn E. Eckert, Eva M. Gulotty, Kevin X. Rodriguez, Zachary D. Tucker, Monimoy Banerjee, Haining Liu, Olaf Wiest, Jeremiah Zartman, Brandon L. Ashfeld
Publikováno v: ChemMedChem. 17(4)
Deregulation of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) plays a significant role in developmental brain defects, early-onset neurodegeneration, neuronal cell loss, dementia, and several types of cancer. Herein, we repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9114835344c6aca773d9afebe6b94634
https://pubmed.ncbi.nlm.nih.gov/34994084
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5
Aroyl Isocyanates as 1,4-Dipoles in a Formal [4 + 1]-Cycloaddition Approach toward Oxazolone Construction
Autor: Brandon L. Ashfeld, Kaitlyn E. Eckert
Publikováno v: Organic Letters. 20:2315-2319
A formal phosphine-mediated [4 + 1]-cycloaddition between a 1,2-dicarbonyl and an aroyl isocyanate to provide oxazolones bearing a disubstituted C5 center is described. By exploiting the carbene-like reactivity of oxyphosphonium enolates as C1 syntho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f1480d2f1f552b6f0873c2f7b2feb
https://doi.org/10.1021/acs.orglett.8b00656
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8
GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment
Autor: Bhavana Palakurthi, Siyuan Zhang, Dennis D. Lee, Kaitlyn E. Eckert, Tiffany A. Toni, Patricia M. Schnepp, Brandon L. Ashfeld, Erin N. Howe, Ian H. Guldner, Treasa K. O'Tighearnaigh
Publikováno v: Cancer research. 77(11)
The impact of altered amino acid metabolism on cancer progression is not fully understood. We hypothesized that a metabolic transcriptome shift during metastatic evolution is crucial for brain metastasis. Here, we report a powerful impact in this set
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71d7540d1e5afcde13962bb0ea3e412
https://pubmed.ncbi.nlm.nih.gov/28400476
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9
Abstract 4934: Brain metastatic microenvironment reshapes cancer cell metabolism through epigenetic up-regulation of glutamate decarboxylase 1
Autor: Ian H. Guldner, Tiffany A. Toni, Dennis D. Lee, Kaitlyn E. Eckert, Treasa K. O'Tighearnaigh, Patricia M. Schnepp, Brandon L. Ashfeld, Bhavana Palakurthi, Siyuan Zhang
Publikováno v: Cancer Research. 77:4934-4934
Cancer metabolism has been well documented to influence primary tumor development. Yet, the role of deregulated metabolism in metastasis progression is not well understood. Based on a distinct metabolic transcriptome profile in brain metastases compa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d74858640db031aa838de5fd7e82c60f
https://doi.org/10.1158/1538-7445.am2017-4934
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