Výsledky vyhledávání - "Kaitlin Zablotsky"

Akademický článek

789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer

Autor: Takuya Osada, Erica Browning, Erika Crosby, Hiroshi Nagata, Melinda Telli, Chaitanya Acharya, Irene Wapnir, Kaitlin Zablotsky, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kellie Malloy, David Canton, Christopher Twitty, Herbert Lyerly

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/c561f28698a24467bc51a278cfc482d2

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Data from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Purpose:Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a minor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e551cda28c1fd25f0ef23972aa309b8
https://doi.org/10.1158/1078-0432.c.6531311.v1

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Figure S5 from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Figure S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a596ca06ec554d854aa13d403d5a24
https://doi.org/10.1158/1078-0432.22484048

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Table S1 from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Table S1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ca7169c9f34582371ebebd076f3eb7
https://doi.org/10.1158/1078-0432.22484039

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Supplementary methods from Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

Supplementary methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b225ca75afa3d921ee14dfdf27630e8
https://doi.org/10.1158/1078-0432.22484042

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Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients

Autor: Chris Twitty, Irene Wapnir, David A. Canton, Hiroshi Nagata, Herbert Kim Lyerly, Donna Bannavong, Erika J. Crosby, Takuya Osada, Melinda L. Telli, Lauren Svenson, Erica Browning, Kellie Malloy, Chaitanya R. Acharya, Reneta Hermiz, Kaitlin Zablotsky

Publikováno v: Cancer Research. 81:PS17-22

Interleukin-12 (IL-12) is a pro-inflammatory cytokine involved in the generation of an inflammatory tumor microenvironment and is critical in eliciting a productive anti-tumor immune response. It has been investigated as an anti-cancer therapeutic us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78795e0c670470bef0f97be592e00ea5
https://doi.org/10.1158/1538-7445.sabcs20-ps17-22

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Abstract P2-09-11: Intratumoral tavokinogene telseplasmid and electroporation in pre-treated inoperable locally advanced or recurrent triple-negative breast cancer

Autor: Mai H. Le, Sharron Gargosky, Erica Browning, Donna Bannavong, Kaitlin Zablotsky, Melinda L. Telli, David A. Canton, Irene Wapnir

Publikováno v: Cancer Research. 79:P2-09

Introduction: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer diagnoses and is associated with a higher risk of recurrence and more aggressive course in the metastatic setting. Emerging data suggest that some pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0ecce7a7dcd8701e19bc4d50620ff5
https://doi.org/10.1158/1538-7445.sabcs18-p2-09-11

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Intratumoral plasmid IL-12 expands CD8(+) T cells and induces a CXCR3 gene signature in triple-negative breast tumors that sensitizes patients to anti-PD-1 therapy

Publikováno v: Clin Cancer Res

Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a mino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48e8953fa4ba2b471eaae121c3944b
https://europepmc.org/articles/PMC8102331/

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Abstract CT022: Intratumoral plasmid IL-12 and electroporation in pre-treated inoperable locally advanced or recurrent triple-negative breast cancer (TNBC)

Autor: Kaitlin Zablotsky, Christopher G. Twitty, Irene Wapnir, Sharron Gargosky, Melinda L. Telli

Publikováno v: Cancer Research. 78:CT022-CT022

Introduction: TNBC accounts for ~15% of breast cancer and is associated with an increased risk of relapse. Emerging data suggest that some TNBC patients benefit from therapies targeting PD-1/PD-L1, but success is limited when patients are heavily pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ed0588a43756cc0f6c9d775d3df4457
https://doi.org/10.1158/1538-7445.am2018-ct022

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