Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kaitlin Watrud"'
Autor:
Julian Taranda, Grinu Mathew, Kaitlin Watrud, Nour El-Amine, Matthew F. Lee, Corey Elowsky, Anastasiia Bludova, Sintia Escobar Avelar, Dawid G. Nowak, Tse-Luen Wee, John E. Wilkinson, Lloyd C. Trotman, Pavel Osten
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110027- (2021)
Summary: Early steps of cancer initiation and metastasis, while critical for understanding disease mechanisms, are difficult to visualize and study. Here, we describe an approach to study the processes of initiation, progression, and metastasis of pr
Externí odkaz:
https://doaj.org/article/89cbad6d853b4185be074d68ba31ccb4
Autor:
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 58-67 (2018)
Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference. Highly se
Externí odkaz:
https://doaj.org/article/ef92114328e64222bc2c836f7460a8f4
Autor:
Adam Naguib, Gyula Bencze, Dannielle D. Engle, Iok I.C. Chio, Tali Herzka, Kaitlin Watrud, Szilvia Bencze, David A. Tuveson, Darryl J. Pappin, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 10, Iss 1, Pp 8-19 (2015)
Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal transduction system that is deregulated in cancer. In stark contrast to PIP inositol head-group
Externí odkaz:
https://doaj.org/article/53b18fd79ede4d1d8913e6ee1a3bf047
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S2. Genetic tools used for dissecting Il6/Stat3/Myc signaling. (A) Scheme of conditional alleles and PCR primers used for assessing the recombination of Pten/ Trp53 genes. (B) Senescence-specific ß-gal staining is detected aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3752ff135b1299d84053c6e9105cff5a
https://doi.org/10.1158/2159-8290.22531532
https://doi.org/10.1158/2159-8290.22531532
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S1. Copy Number Alteration analysis of human prostate cancer confirms loss of PTEN and TP53 genes as a genetic hallmark of metastatic prostate cancer. (A) Co-deletion frequency for PTEN and TP53 in metastatic and primary prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22326194e1055bee8ad81bfb6aeb82
https://doi.org/10.1158/2159-8290.22531538.v1
https://doi.org/10.1158/2159-8290.22531538.v1
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S7. Pathway to Pten/ Trp53 deficient prostate metastasis and therapy resistance. Pten-loss triggers PIP3 signaling to activate AKT, which prompts activation of the p53/ p21/ p16 tumor suppressors and senescence arrest. Suppressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc22895428a5ce3e29b0e0edd7fff7
https://doi.org/10.1158/2159-8290.22531517
https://doi.org/10.1158/2159-8290.22531517
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S3. Tools used for targeting of Il6 and Stat3. (A) Il6 neutralizing antibody specifically decreases the proliferation of Pten/ Trp53 deficient primary MEFs. ANOVA, Dunnett's post-hoc test, **p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d772a30845b6c5301745242e6c9f25
https://doi.org/10.1158/2159-8290.22531529.v1
https://doi.org/10.1158/2159-8290.22531529.v1
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S4. Activation of Stat3/Myc signaling is specific to Ptenpc-/-; Trp53pc-/-prostate and leads to stromal expansion. (A) H&E analysis of prostates from all studied genotypes reveals massive stromal expansion after co-deletion of Pt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73377cff08828121e3d85dec1e12d891
https://doi.org/10.1158/2159-8290.22531526
https://doi.org/10.1158/2159-8290.22531526
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S6. Ar expression in primary and metastatic tumors. (A) IHC analysis of the Ar status in RapidCaP lesions shows no significant Ar staining (left panel) while most prostate glands show strong nuclear Ar staining. (B) The wild type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17006186c51f2f4aeec7dc9f87e014a0
https://doi.org/10.1158/2159-8290.22531520
https://doi.org/10.1158/2159-8290.22531520
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure Legends from MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03000e137a751529c248cda1232435d7
https://doi.org/10.1158/2159-8290.22531541.v1
https://doi.org/10.1158/2159-8290.22531541.v1