Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kaitlin Summerville"'
Autor:
LuAnne McNulty, Brian M. Lingerfelt, Heather L. Handl, Moses Lee, Adrienne E. Scott, Stephen J. Hudson, Carly A. Price, Tiffany T. Howard, Bethany Purnell, Kaitlin Summerville, J. Phillip Bowen, Heather M. Townes, John A. Hartley, Konstantinos Kiakos
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2941-2952
The design, synthesis and biological evaluation of novel seco -iso-cyclopropylfurano[2,3- e ]indoline ( seco -iso-CFI) and the seco -cyclopropyltetrahydrofurano[2,3- f ]quinoline ( seco -CFQ) analogues of the duocarmycins are described. These novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03e9d616b3faefe48549aaae76b912f
https://doi.org/10.1016/s0968-0896(02)00157-8
https://doi.org/10.1016/s0968-0896(02)00157-8
Autor:
Konstantinos Kiakos, Stephen J. Hudson, Bethany Purnell, Tetsuji Asao, Kaitlin Summerville, Moses Lee, Carly A. Price, Caroline O'Hare, John A. Hartley, Atsushi Sato, Amanda O’Kelley
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
The design and synthesis of three novel bisalkylating agents derived from the achiral seco-duocarmycin or CC-1065 analogs and pyrrolobenzodiazepines (PBDs) are described: achiral seco-CBI (cyclopropanebenz[e]indoline)-PBD 11, achiral seco-CI-PBD 12,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56446fd760492681ce869865a8c23659
https://pubmed.ncbi.nlm.nih.gov/16919946
https://pubmed.ncbi.nlm.nih.gov/16919946
Autor:
Konstantinos Kiakos, Brian M. Lingerfelt, Heather M. Townes, Stephen J. Hudson, Kaitlin Summerville, John A. Hartley, Moses Lee, Adrienne E. Scott, Bethany Purnell
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 2(2)
Racemic seco-iso-CFI (cyclopropylfurano[e]indoline) analogs of the duocarmycins and CC-1065 have recently been reported by our group. These compounds covalently react with AT-rich sequences of DNA, and they exhibit potent cytotoxicity against cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f9cdd6d5a07b886c3403af36fef608
https://pubmed.ncbi.nlm.nih.gov/16787363
https://pubmed.ncbi.nlm.nih.gov/16787363
Autor:
Bethany Purnell, Heather M. Townes, Carly A. Price, Virginia Carnahan, John David Trzupek, Moses Lee, Stephen J. Hudson, Konstantinos Kiakos, Kimberly Johnson, Kaitlin Summerville, Sara Centioni, Stanley Kupchinsky, Heather L. Handl, John A. Hartley, Tiffany T. Howard, Shane G. Roller, James L. Toth
Publikováno v:
Bioorganicmedicinal chemistry. 12(23)
The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline (or achiral seco-CI) analogs (5a-o) of CC-1065 and the duocarmycins are described. The achiral seco-CI analogs contain a 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6704d6ec05802ce1376e2a6020a367d2
https://pubmed.ncbi.nlm.nih.gov/15519165
https://pubmed.ncbi.nlm.nih.gov/15519165