Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kaitlin R, Sprouse"'
Autor:
Marcos C. Miranda, Elizabeth Kepl, Mary Jane Navarro, Chengbo Chen, Max Johnson, Kaitlin R. Sprouse, Cameron Stewart, Anne Palser, Adian Valdez, Deleah Pettie, Claire Sydeman, Cassandra Ogohara, John C. Kraft, Minh Pham, Michael Murphy, Sam Wrenn, Brooke Fiala, Rashmi Ravichandran, Daniel Ellis, Lauren Carter, Davide Corti, Paul Kellam, Kelly Lee, Alexandra C. Walls, David Veesler, Neil P. King
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract We previously described a two-component protein nanoparticle vaccine platform that displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when adjuvanted with AS03, was shown to elicit robust neutralizing antibody and
Externí odkaz:
https://doaj.org/article/649dcf2c588340c39547078121604655
Autor:
Jimin Lee, Cameron Stewart, Alexandra Schäfer, Elizabeth M. Leaf, Young-Jun Park, Daniel Asarnow, John M. Powers, Catherine Treichel, Kaitlin R. Sprouse, Davide Corti, Ralph Baric, Neil P. King, David Veesler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a v
Externí odkaz:
https://doaj.org/article/780e43f46b0341b2b056a3f52e383c25
Autor:
Amin Addetia, Young-Jun Park, Tyler Starr, Allison J. Greaney, Kaitlin R. Sprouse, John E. Bowen, Sasha W. Tiles, Wesley C. Van Voorhis, Jesse D. Bloom, Davide Corti, Alexandra C. Walls, David Veesler
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112621- (2023)
Summary: Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody responses elicited by prior vaccination and infection. The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralizati
Externí odkaz:
https://doaj.org/article/958618b6d6dc4a05a3c785030b25accd
Autor:
Megan A O'Connor, David W Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B Lewis, Brieann Brown, Megan N Fredericks, Kaitlin R Sprouse, Hillary C Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T Edlefsen, Amit P Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H Erasmus
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011298 (2023)
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines. Although several vaccines have received emergency approval through various public health agencies, the SARS-CoV-2 pandemic continues. Emergent variants of concern, waning
Externí odkaz:
https://doaj.org/article/d4af23eb43be40bcaa467db922cd5121
Autor:
John E. Bowen, Amin Addetia, Ha V. Dang, Cameron Stewart, Jack T. Brown, William K. Sharkey, Kaitlin R. Sprouse, Alexandra C. Walls, Ignacio G. Mazzitelli, Jennifer K. Logue, Nicholas M. Franko, Nadine Czudnochowski, Abigail E. Powell, Exequiel Dellota, Kumail Ahmed, Asefa Shariq Ansari, Elisabetta Cameroni, Andrea Gori, Alessandra Bandera, Christine M. Posavad, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Najeeha Talat Iqbal, Davide Corti, Jorge Geffner, Gyorgy Snell, Renata Grifantini, Helen Y. Chu, David Veesler
Publikováno v:
Science. 377:890-894
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide.
Autor:
Yupeng Feng, Meng Yuan, John M. Powers, Mengyun Hu, Jennifer E. Munt, Prabhu S. Arunachalam, Sarah R. Leist, Lorenza Bellusci, JungHyun Kim, Kaitlin R. Sprouse, Lily E. Adams, Sumana Sundaramurthy, Xueyong Zhu, Lisa M. Shirreff, Michael L. Mallory, Trevor D. Scobey, Alberto Moreno, Derek T. O’Hagan, Harry Kleanthous, Francois J. Villinger, David Veesler, Neil P. King, Mehul S. Suthar, Surender Khurana, Ralph S. Baric, Ian A. Wilson, Bali Pulendran
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that evade immunity elicited by vaccination has placed an imperative on the development of countermeasures that provide broad protection against SARS-CoV-2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e844aa221111b38e021bd5c435cfe2f
Autor:
John E. Bowen, Young-Jun Park, Cameron Stewart, Jack T. Brown, William K. Sharkey, Alexandra C. Walls, Anshu Joshi, Kaitlin R. Sprouse, Matthew McCallum, M. Alejandra Tortorici, Nicholas M. Franko, Jennifer K. Logue, Ignacio G. Mazzitelli, Annalee W. Nguyen, Rui P. Silva, Yimin Huang, Jun Siong Low, Josipa Jerak, Sasha W. Tiles, Kumail Ahmed, Asefa Shariq, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Gyorgy Snell, Christine M. Posavad, Najeeha Talat Iqbal, Jorge Geffner, Alessandra Bandera, Andrea Gori, Federica Sallusto, Jennifer A. Maynard, Shane Crotty, Wesley C. Van Voorhis, Carlos Simmerling, Renata Grifantini, Helen Y. Chu, Davide Corti, David Veesler
Publikováno v:
Science Immunology, 7 (78)
Numerous safe and effective coronavirus disease 2019 vaccines have been developed worldwide that use various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2fccde0b0e427d8e4670b2fff9021d
https://hdl.handle.net/20.500.11850/596105
https://hdl.handle.net/20.500.11850/596105
Autor:
M. Alejandra Tortorici, Alessandra Franzetti Pellanda, Amalio Telenti, Alexandra C. Walls, Christian Garzoni, Jessica Bassi, Herbert W. Virgin, Mary-Jane Navarro, David Veesler, Christian Saliba, Alexander Chen, Matthew McCallum, Katja Culap, Sonja Bernasconi Guastalla, Chiara Silacci-Fregni, Gyorgy Snell, Elisabetta Cameroni, Luca Piccoli, Wesley C. Van Voorhis, Matteo Samuele Pizzuto, Laura E. Rosen, John E. Bowen, Siro Bianchi, Anna De Marco, Stefano Jaconi, Dora Pinto, Maria De Agostini, Giovanni Bona, Kaitlin R. Sprouse, Julia di Iulio, Sasha W Tilles, Davide Corti
Publikováno v:
Science. 373:648-654
SARS-CoV-2 from alpha to epsilon As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of concern becau
Autor:
Young-Jun Park, Dora Pinto, Alexandra C. Walls, Zhuoming Liu, Anna De Marco, Fabio Benigni, Fabrizia Zatta, Chiara Silacci-Fregni, Jessica Bassi, Kaitlin R. Sprouse, Amin Addetia, John E. Bowen, Cameron Stewart, Martina Giurdanella, Christian Saliba, Barbara Guarino, Michael A. Schmid, Nicholas M. Franko, Jennifer K. Logue, Ha V. Dang, Kevin Hauser, Julia di Iulio, William Rivera, Gretja Schnell, Anushka Rajesh, Jiayi Zhou, Nisar Farhat, Hannah Kaiser, Martin Montiel-Ruiz, Julia Noack, Florian A. Lempp, Javier Janer, Rana Abdelnabi, Piet Maes, Paolo Ferrari, Alessandro Ceschi, Olivier Giannini, Guilherme Dias de Melo, Lauriane Kergoat, Hervé Bourhy, Johan Neyts, Leah Soriaga, Lisa A. Purcell, Gyorgy Snell, Sean P. J. Whelan, Antonio Lanzavecchia, Herbert W. Virgin, Luca Piccoli, Helen Y. Chu, Matteo Samuele Pizzuto, Davide Corti, David Veesler
Publikováno v:
Science
Science, 2022, pp.First release. ⟨10.1126/science.adc9127⟩
bioRxiv
Science, 2022, pp.First release. ⟨10.1126/science.adc9127⟩
bioRxiv
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a35e4a51f14a3fa4984e4ce4734fe2
https://hal-pasteur.archives-ouvertes.fr/pasteur-03827707/file/science.adc9127.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03827707/file/science.adc9127.pdf
Autor:
John C. Kraft, Minh N. Pham, Laila Shehata, Mitch Brinkkemper, Seyhan Boyoglu-Barnum, Kaitlin R. Sprouse, Alexandra C. Walls, Suna Cheng, Mike Murphy, Deleah Pettie, Maggie Ahlrichs, Claire Sydeman, Max Johnson, Alyssa Blackstone, Daniel Ellis, Rashmi Ravichandran, Brooke Fiala, Samuel Wrenn, Marcos Miranda, Kwinten Sliepen, Philip J.M. Brouwer, Aleksandar Antanasijevic, David Veesler, Andrew B. Ward, Masaru Kanekiyo, Marion Pepper, Rogier W. Sanders, Neil P. King
Publikováno v:
Cell Reports Medicine, 3(10):100780. Cell Press
Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs, and several have established records of clinical safety and efficacy. Yet the rules for how immune responses specific to nanoparticle scaffolds affect the immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4dee6a89727fda946352d9dc45e9a4
https://pure.amc.nl/en/publications/antigen-and-scaffoldspecific-antibody-responses-to-protein-nanoparticle-immunogens(715ac779-3b1c-4879-9a6b-1a3c0e954171).html
https://pure.amc.nl/en/publications/antigen-and-scaffoldspecific-antibody-responses-to-protein-nanoparticle-immunogens(715ac779-3b1c-4879-9a6b-1a3c0e954171).html