Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kaitlin Kiernan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4+ T cells through insulin receptor (IR) and IGF-1 receptor (IGF-1R) signaling. Here, we describe specific and distinct roles for these hormones
Externí odkaz:
https://doaj.org/article/0d675f4c3a9a4de0927b2c906d221a20
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286470 (2023)
Background/objectivesLeptin is an adipokine secreted in proportion to adipocyte mass and is therefore increased in obesity. Leptin signaling has been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell number and funct
Externí odkaz:
https://doaj.org/article/fe09b57e552b4c48b0a5bce4a83e7874
Autor:
Kaitlin Kiernan, Nancie J. MacIver
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating syst
Externí odkaz:
https://doaj.org/article/d4aac1579fab415a828085dc3f4cc1e5
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Immune cell function and metabolism are closely linked. Many studies have now clearly demonstrated that alterations in cellular metabolism influence immune cell function and that, conversely, immune cell function determines the cellular metabolic sta
Externí odkaz:
https://doaj.org/article/6efe267f63c141b5af96f04d6fa6e582
Autor:
William R. Green, Yazan Alwarawrah, Nancie J. MacIver, Melinda A. Beck, Kaitlin Kiernan, Laura P. Hale, Amanda G. Nichols, Jonathan Warren, William Eisner
Publikováno v:
International journal of obesity (2005)
Background Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role. T cell function is highly influenced by the cellular metabolic state; however, it remains unknown how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c7ddf681b50ab29326c0028bae6c26
https://doi.org/10.1038/s41366-020-00692-3
https://doi.org/10.1038/s41366-020-00692-3
Autor:
Kaitlin Kiernan, Nancie J. MacIver
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology
Frontiers in Immunology
Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9945a810c755d2fb5bccc9ee9e206532
https://pubmed.ncbi.nlm.nih.gov/33584724
https://pubmed.ncbi.nlm.nih.gov/33584724
Autor:
Nancie J. MacIver, Kaitlin Kiernan
Publikováno v:
Journal of the Endocrine Society
Obesity leads to altered immunity characterized by increased risk of autoimmunity, poor response to infection, and impaired vaccine response. T cells play an important role in this obesity-associated immune response; however, the mechanisms by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813de699bb5eb865c0f3afb728e92bb5
http://europepmc.org/articles/PMC7207621
http://europepmc.org/articles/PMC7207621
Autor:
Nancie J. MacIver, Kaitlin Kiernan
Publikováno v:
Trends in Endocrinology & Metabolism. 31:1-2
In their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ddcd678f6e2d5e656ce0b8b1cf9fad
https://doi.org/10.1016/j.tem.2019.11.002
https://doi.org/10.1016/j.tem.2019.11.002
Autor:
Kaitlin Kiernan, Nancie J. MacIver
Publikováno v:
Immunity. 49(1)
In this issue of Immunity, Sestan et al. (2018) show that viral-induced inflammation leads to insulin resistance in skeletal muscle, followed by compensatory hyperinsulinemia, which promotes the anti-viral effector response of CD8+ T cells. Interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d570ecdf5ea9a351987646b646f8b3
https://pubmed.ncbi.nlm.nih.gov/29958802
https://pubmed.ncbi.nlm.nih.gov/29958802
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Immune cell function and metabolism are closely linked. Many studies have now clearly demonstrated that alterations in cellular metabolism influence immune cell function and that, conversely, immune cell function determines the cellular metabolic sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245657e9be19052e7ad99b673e970817
https://pubmed.ncbi.nlm.nih.gov/29868016
https://pubmed.ncbi.nlm.nih.gov/29868016