Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kaitlin A. Read"'
Autor:
Mohamed M. Shamseldin, Kaitlin A. Read, Jesse M. Hall, Jasmine A. Tuazon, Jessica M. Brown, Myra Guo, Yash A. Gupta, Rajendar Deora, Kenneth J. Oestreich, Purnima Dubey
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionAdjuvants added to subunit vaccines augment antigen-specific immune responses. One mechanism of adjuvant action is activation of pattern recognition receptors (PRRs) on innate immune cells. Bordetella colonization factor A (BcfA); an oute
Externí odkaz:
https://doaj.org/article/6c9a0d90eef04f6fb4fb437e417dcb83
Autor:
Kaitlin A. Read, Devin M. Jones, Srijana Pokhrel, Emily D. S. Hales, Aditi Varkey, Jasmine A. Tuazon, Caprice D. Eisele, Omar Abdouni, Abbey Saadey, Melissa R. Leonard, Robert T. Warren, Michael D. Powell, Jeremy M. Boss, Emily A. Hemann, Jacob S. Yount, Gang Xin, Hazem E. Ghoneim, Chan-Wang J. Lio, Aharon G. Freud, Patrick L. Collins, Kenneth J. Oestreich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
Externí odkaz:
https://doaj.org/article/db3616878fde4edbb2df4e62fd0817bd
Autor:
Mohamed M. Shamseldin, Adam Kenney, Ashley Zani, John P. Evans, Cong Zeng, Kaitlin A. Read, Jesse M. Hall, Supranee Chaiwatpongsakorn, K.C. Mahesh, Mijia Lu, Mostafa Eltobgy, Parker Denz, Rajendar Deora, Jianrong Li, Mark E. Peeples, Kenneth J. Oestreich, Shan-Lu Liu, Kara N. Corps, Jacob S. Yount, Purnima Dubey
Publikováno v:
The Journal of Immunology. 210:1257-1271
Vaccines against SARS-CoV-2 that induce mucosal immunity capable of preventing infection and disease remain urgently needed. In this study, we demonstrate the efficacy of Bordetella colonization factor A (BcfA), a novel bacteria-derived protein adjuv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1830d7de1b726b0f3cdfdf98bca18d
https://doi.org/10.4049/jimmunol.2200297
https://doi.org/10.4049/jimmunol.2200297
Autor:
Qinghui Mu, Husen Zhang, Xiaofeng Liao, Kaisen Lin, Hualan Liu, Michael R. Edwards, S. Ansar Ahmed, Ruoxi Yuan, Liwu Li, Thomas E. Cecere, David B. Branson, Jay L. Kirby, Poorna Goswami, Caroline M. Leeth, Kaitlin A. Read, Kenneth J. Oestreich, Miranda D. Vieson, Christopher M. Reilly, Xin M. Luo
Publikováno v:
Microbiome, Vol 5, Iss 1, Pp 1-12 (2017)
Abstract Background Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at a higher risk of infections. New knowledge of diseas
Externí odkaz:
https://doaj.org/article/8cbdedad4872408eb4023944473cb663
Autor:
Jingjing Ren, Michelle D. Catalina, Kristin Eden, Xiaofeng Liao, Kaitlin A. Read, Xin Luo, Ryan P. McMillan, Matthew W. Hulver, Matthew Jarpe, Prathyusha Bachali, Amrie C. Grammer, Peter E. Lipsky, Christopher M. Reilly
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are incompletely characterized.
Externí odkaz:
https://doaj.org/article/912a3f150eb740fdb3086057c5f2a8a7
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
CD4+ T helper cells are capable of differentiating into a number of effector subsets that perform diverse functions during adaptive immune responses. The differentiation of each of these subsets is governed, in large part, by environmental cytokine s
Externí odkaz:
https://doaj.org/article/95774922fdfa4c9a82d8cb79f9272e50
Autor:
Paul W. McDonald, Kaitlin A. Read, Chandra E. Baker, Ashlyn E. Anderson, Michael D. Powell, André Ballesteros-Tato, Kenneth J. Oestreich
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
It remains incompletely understood how cytokines shape TH1 cell differentiation to central memory T (TCM) and follicular T helper (TFH) cells. Here the authors show that TH1 cells can co-initiate the expression of both TFH and TCM gene programs and t
Externí odkaz:
https://doaj.org/article/ed8ba91356794cf9a2f6d0b4dfd365cb
Autor:
Jasmine A. Tuazon, Kaitlin A. Read, Bharath K. Sreekumar, Michael J. Yaeger, Sanjay Varikuti, Devin M. Jones, Robert T. Warren, Michael D. Powell, Mustafa N. Rasheed, Elizabeth G. Duncan, Lauren M. Childs, Kymberly M. Gowdy, Kenneth J. Oestreich
The Ikaros zinc finger transcription factor Eos has been commonly implicated in regulatory T cells to promote their immunosuppressive functions. Paradoxically, a new role is emerging for Eos in promoting pro-inflammatory responses of conventional CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe3a4a73b0c64015139a42b4ecefef6d
https://doi.org/10.1101/2022.11.02.514868
https://doi.org/10.1101/2022.11.02.514868
Publikováno v:
Immunol Rev
Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a2feecea314c33f8b8ef6183b81986
https://doi.org/10.1111/imr.12936
https://doi.org/10.1111/imr.12936
Autor:
Mohamed M. Shamseldin, Ashley Zani, Adam Kenney, Jack Evans, Cong Zeng, Kaitlin A. Read, Kyle Caution, Jesse M. Hall, Jessica M. Brown, Gilian Gunsch, Kara N. Corps, Supranee Chaiwatpongsakorn, KC Mahesh, Mijia Lu, Rajendar Deora, Mark E. Peeples, Jianrong Li, Kenneth J. Oestreich, Shan-Lu Liu, Jacob S. Yount, Purnima Dubey
Vaccines against SARS-CoV-2 that induce mucosal immunity capable of preventing infection and disease remain urgently needed. We show that intramuscular priming of mice with an alum and BcfA-adjuvanted Spike subunit vaccine, followed by a BcfA-adjuvan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd777f43e75d4e14d8ece03c83ec4cfe
https://doi.org/10.1101/2022.04.06.487394
https://doi.org/10.1101/2022.04.06.487394