An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Autor: de Leon J; Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA.; Department of Psychiatry, University of Kentucky, Lexington, KY, USA.; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain.; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain., Schoretsanitis G; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland.; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA., Smith RL; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway., Molden E; Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway., Solismaa A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Psychiatry, Tampere University Hospital, Tampere, Finland., Seppälä N; Department of Psychiatry, Satasairaala, Finland., Kopeček M; National Institute of Mental Health, Klecany, Czech Republic.; Department of Psychiatry, Charles University, Third Faculty of Medicine, Prague, Czech Republic., Švancer P; National Institute of Mental Health, Klecany, Czech Republic.; Department of Psychiatry, Charles University, Third Faculty of Medicine, Prague, Czech Republic., Olmos I; Clinical Pharmacology Unit and Pharmacy Department, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay., Ricciardi C; Clinical Pharmacology Unit and Outpatient Clinic, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay., Iglesias-Garcia C; Universidad de Oviedo. CIBERSAM. INEUROPA. ISPA-FIMBA, Oviedo, Spain.; Hospital Valle del Nalón, Langreo, Spain., Iglesias-Alonso A; Hospital Universitario Central de Asturias, Oviedo, Spain., Spina E; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Ruan CJ; Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Beijing, China.; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China., Wang CY; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.; Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China., Wang G; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China., Tang YL; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Substance Abuse Treatment Program, Atlanta VA Medical Center, Decatur, Georgia, USA., Lin SK; Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan., Lane HY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Psychiatry and Brain Disease Research Center, China Medical University Hospital, Taichung, Taiwan.; Department of Psychology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan., Kim YS; Department of Neuropsychiatry, Nowon Eulji Medical Center, Eulji University, School of Medicine, Seoul, Korea., Kim SH; Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Rajkumar AP; Department of Psychiatry, Christian Medical College, Vellore, India.; Institute of Mental Health, Jubilee Campus, University of Nottingham, Triumph Road, Nottingham, United Kingdom., González-Esquivel DF; Instituto Nacional de Neurología y Neurocirugía, México City, México., Jung-Cook H; Instituto Nacional de Neurología y Neurocirugía, México City, México.; Facultad de Química, Universidad Nacional Autónoma de México (UNAM), México City, México., Baptista T; Department of Physiology, Los Andes University Medical School, Mérida, Venezuela., Rohde C; Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nielsen J; Mental Health Centre Glostrup, Copenhagen University Hospital, Copenhagen, Denmark., Verdoux H; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France., Quiles C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France., Sanz EJ; Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands, Spain.; Hospital Universitario de Canarias, Tenerife, Spain., De Las Cuevas C; Department of Internal Medicine, Dermatology and Psychiatry, School of Medicine, and Instituto Universitario de Neurociencia (IUNE), University of La Laguna, Canary Islands, Spain., Cohen D; Dutch Clozapine Collaboration Group, Castricum, The Netherlands.; FACT-team in Heerhugowaard, Department of Severe Mental Illness, Mental Health Services North-Holland North, The Netherlands., Schulte PFJ; Dutch Clozapine Collaboration Group, Castricum, The Netherlands.; Mental Health Team Alkmaar, Mental Health Services Noord-Holland-Noord, Alkmaar, The Netherlands., Ertuğrul A; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey., Anıl Yağcıoğlu AE; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey., Chopra N; Addictions Division, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., McCollum B; Eastern State Hospital, Lexington, Kentucky, USA., Shelton C; Department of Psychiatry, University of Kentucky, Lexington, KY, USA.; Eastern State Hospital, Lexington, Kentucky, USA., Cotes RO; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Kaithi AR; Hazelwood Center, Louisville, Kentucky, USA., Kane JM; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead, New York, USA., Farooq S; School of Medicine, Keele University, Staffordshire, and Midlands Partnership NHS Foundation Trust, Staffordshire, United Kingdom., Ng CH; Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia., Bilbily J; Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA., Hiemke C; Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Germany., López-Jaramillo C; Grupo de Investigación en Psiquiatría GIPSI, Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.; Programa Trastornos del Ánimo, Hospital Universitario San Vicente Fundación, Medellín, Colombia., McGrane I; Department of Pharmacy Practice, University of Montana, Missoula, USA., Lana F; Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Barcelona, Spain.; Department of Psychiatry, Autonomous University of Barcelona, Spain., Eap CB; Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neurosciences, Lausanne University Hospital and University of Lausanne, Switzerland.; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Switzerland., Arrojo-Romero M; Department of Psychiatry, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain., Rădulescu FŞ; Center for Drug Sciences, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Seifritz E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland., Every-Palmer S; Te Korowai Whāriki Central Regional Forensic Service, Capital and Coast District Health Board, Wellington, New Zealand.; Department of Psychological Medicine, University of Otago, Wellington, New Zealand., Bousman CA; Departments of Medical Genetics, Psychiatry, Physiology & Pharmacology, and Community Health Sciences University of Calgary, Alberta, Canada., Bebawi E; Faculty of Medicine, University of Montreal, Montreal, Canada.; Department of Pharmacy, Hôpital du Sacré-Cœur de Montréal, Montreal, Canada., Bhattacharya R; East London NHS Foundation Trust, London, United Kingdom.; Honorary Clinical Senior Lecturer, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom., Kelly DL; Department of Psychiatry, School of Medicine, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Otsuka Y; Department of Psychiatry, Asahi General Hospital, Chiba, Japan., Lazary J; National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary., Torres R; Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Yecora A; Secretaría de Salud Mental y Adicciones, Ministerio de Salud de la Provincia de Jujuy, San Salvador de Jujuy, Argentina., Motuca M; Instituto Vilapriño, Center for Studies, Assistance and Research in Neurosciences, Mendoza, Argentina., Chan SKW; Department of Psychiatry, LSK Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR., Zolezzi M; College of Pharmacy, QU Health, Qatar University, Doha, Qatar., Ouanes S; Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar., De Berardis D; NHS, Department of Mental Health, 'G. Mazzini' Hospital, Teramo, Italy., Grover S; Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Procyshyn RM; British Columbia Mental Health and Substance Use Research Institute, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada., Adebayo RA; Federal Neuropsychiatric Hospital Yaba, Lagos, Nigeria., Kirilochev OO; Department of Clinical Pharmacology, Astrakhan State Medical University, Astrakhan, Russian Federation., Soloviev A; Department of Psychiatry and Clinical Psychology, Northern State Medical University, Arkhangelsk, Russia., Fountoulakis KN; 3rd Department of Psychiatry, Division of Neurosciences, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece., Wilkowska A; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland., Cubała WJ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland., Ayub M; Department of Psychiatry, Queens University, Kingston, Canada., Silva A; Psychiatry Department, Centro Hospitalar Universitário de S. João, Porto, Portugal.;  Faculdade de Medicina da Universidade do Porto, Porto, Portugal., Bonelli RM;  Sigmund Freud University, Vienna, Austria., Villagrán-Moreno JM;  Department of Neurosciences, Jerez University Hospital, Andalusian Health Service, University of Cadiz, Jerez, Spain., Crespo-Facorro B;  Department of Psychiatry, School of Medicine, University Hospital Virgen del Rocio-IBIS, Sevilla, Spain.;  Spanish Network for Research in Mental Health (CIBERSAM), Sevilla, Spain., Temmingh H; Department of Psychiatry and Mental Health, University of Cape Town, Valkenberg Hospital, Western Cape, Cape Town, South Africa., Decloedt E; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Pedro MR; Hospital Central de Maputo, Maputo, Mozambique., Takeuchi H; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan., Tsukahara M; Department of Psychiatry, Okayama Psychiatric Medical Center, Okayama, Japan., Gründer G; Central Institute of Mental Health, Department of Molecular Neuroimaging, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Sagud M; Department of Psychiatry, School of Medicine, University of Zagreb, Zagreb, Croatia.; Department for Psychiatry and Psychological Medicine, University Hospital Center Zagreb, Croatia., Celofiga A; Department of Psychiatry, University Medical Centre Maribor, Maribor, Slovenia., Ignjatovic Ristic D; University of Kragujevac, Faculty of Medical Sciences, Department of Psychiatry, Kragujevac, Serbia., Ortiz BB; Group of Resistant Schizophrenia (GER), Schizophrenia Program (Proesq), Federal University of Sao Paulo, SP, Brazil., Elkis H; Department and Institute of Psychiatry, University of São Paulo Medical School (FMUSP), Sao Paulo, Brazil., Pacheco Palha AJ; Department and Institute of Psychiatry and Mental Health, Oporto Faculty of Medicine, Oporto, Portugal.; Casa de Salidedo Som Jesus (Psychiatric Hospital), Oporto, Portugal., LLerena A; INUBE Biosanitary Research Institute of Extremadura. Extremadura University Hospital and Medical School, Badajoz, Spain.; Spanish Network for Research in Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain., Fernandez-Egea E; Cambridge Psychosis Centre, Cambrigeshire and Peterborough NHS Foundation Trust & Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom., Siskind D; Metro South Addiction and Mental Health Service, Brisbane, Australia.; Queensland Centre for Mental Health Research and School of Clinical Medicine, University of Queensland, Brisbane, Australia., Weizman A; Research Unit, Geha Mental Health Center and Molecular Psychiatry Laboratory, Felsenstein Medical Research Center, Tel Aviv, Israel.; Department of Psychiatry Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Masmoudi R; Psychiatry 'A' Department, Hedi Chaker University Hospital, Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Sfax, Tunisia., Mohd Saffian S; Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Leung JG; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA., Buckley PF; School of Medicine, Virginia Commonwealth University, Richmond, VA, USA., Marder SR; Semel Institute for Neuroscience at UCLA, Los Angeles, CA, USA.; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles, CA, USA., Citrome L; New York Medical College, Department of Psychiatry and Behavioral Sciences, Valhalla, NY, USA., Freudenreich O; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Correll CU; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks, New York, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Hempstead, New York, USA.; Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany., Müller DJ; Addictions Division, Centre for Addiction and Mental Health, Toronto, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Pharmacopsychiatry [Pharmacopsychiatry] 2022 Mar; Vol. 55 (2), pp. 73-86. Date of Electronic Publication: 2021 Dec 15.

Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview.

Autor: de Leon J; Mental Health Research Center, Eastern State Hospital, Lexington, Kentucky, USA.; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain, and Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain., Rajkumar AP; Department of Psychiatry, Christian Medical College, Vellore, Tamil Nadu, India.; Institute of Mental Health, University of Nottingham, Nottingham, United Kingdom., Kaithi AR; Hazelwood Center, Louisville, Kentucky, USA., Schoretsanitis G; Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, USA., Kane JM; Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York, USA.; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA., Wang CY; Department of Psychiatry, The National Clinical Research Centre for Mental Disorders and Beijing Key Lab of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, China., Tang YL; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, and Substance Abuse Treatment Program, Atlanta VA Medical Center, Decatur, Georgia, USA., Lin SK; Department of General Psychiatry, Taipei City, Psychiatric Center, Taipei, Taiwan, and Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan., Hong KS; Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea., Farooq S; School of Primary, Community and Social Care, Faulty of Medicine and Health Sciences, Keele University, Staffordshire, and Midlands Partnership NHS Foundation Trust, Staffordshire, United Kingdom., Ng CH; Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia., Ruan CJ; Laboratory of Clinical Psychopharmacology & The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China., Andrade C; Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Publikováno v: Indian journal of psychological medicine [Indian J Psychol Med] 2020 Jan 06; Vol. 42 (1), pp. 4-10. Date of Electronic Publication: 2020 Jan 06 (Print Publication: 2020).