Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Kaisaki, P."'
Autor:
Tomoki Imaoka, Reiko Onuki-Nagasaki, Hiroshi Kimura, Kempei Tai, Mitsuharu Ishii, Ayaka Nozue, Ikuko Kaisaki, Misa Hoshi, Kengo Watanabe, Kazuya Maeda, Takashi Kamizono, Takahiro Yoshioka, Takashi Fujimoto, Taku Satoh, Hiroko Nakamura, Osamu Ando, Hiroyuki Kusuhara, Yuzuru Ito
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract There is an urgent need for novel methods that can accurately predict intestinal absorption of orally administered drugs in humans. This study aimed to evaluate the potential of a novel gut microphysiological system (MPS), gut MPS/Fluid3D-X,
Externí odkaz:
https://doaj.org/article/6a1c420ff7d34af0a6f6855d7e06fa8a
Autor:
Alistair T. Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M. Taylor, Mona Hashim, Eduardo Calpena, Pamela J. Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schwessinger, Jim R. Hughes, Gerton Lunter, Helene Dreau, Matteo Ferla, Lukas Lange, Yesim Kesim, Vassilis Ragoussis, Dimitrios V. Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben-Ami, David L. Bennett, Celeste Bento, Edward Blair, Charlotte Brasch-Andersen, Katherine R. Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E. Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Yin Dong, James E. Dunford, Renzo Guerrini, Adrian L. Harris, Jane Hartley, Georg Hollander, Kassim Javaid, Maureen Kane, Deirdre Kelly, Dominic Kelly, Samantha J. L. Knight, Alexandra Y. Kreins, Erika M. Kvikstad, Craig B. Langman, Tracy Lester, Kate E. Lines, Simon R. Lord, Xin Lu, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian Marsden, Joanne Mason, Simon J. McGowan, Davide Mei, Hana Mlcochova, Yoshiko Murakami, Andrea H. Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y. Patel, Melissa M. Pentony, Chris Pugh, Aboulfazl Rad, Archana Ramesh, Simone G. Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D. Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V. Thakker, Stephen R. F. Twigg, Holm H. Uhlig, Richard van Wijk, Barbara Vona, Steven Wall, Jing Wang, Hugh Watkins, Jaroslav Zak, Anna H. Schuh, Usha Kini, Andrew O. M. Wilkie, Niko Popitsch, Jenny C. Taylor
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Background Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disappointingly l
Externí odkaz:
https://doaj.org/article/c9f00f4d0c70402d8c69f3f7e4981fbc
Akademický článek
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Autor:
Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from th
Externí odkaz:
https://doaj.org/article/d979937a0bc24797ae8857c1bcbbda14
Autor:
Adrian M. Shields, Alistair T. Pagnamenta, Andrew J. Pollard, OxClinWGS, Jenny C. Taylor, Holger Allroggen, Smita Y. Patel, Samantha J. L. Knight, Niko Popitsch, Carme Camps, Melissa M. Pentony, Erika M. Kvikstad, Lukas Lange, Mona Hashim, Steve Harris, Mark Tilley, Dimitris Vavoulis, Pamela Kaisaki, Vassilis Ragoussis, Matteo Feral
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Deficiency of complement factor I is a rare immunodeficiency that typically presents with increased susceptibility to encapsulated bacterial infections. However, non-infectious presentations including rheumatological, dermatological and neurological
Externí odkaz:
https://doaj.org/article/b00ed76bf8364c97a638ff44d5f2c49e
Autor:
Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3671-3683 (2016)
To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown
Externí odkaz:
https://doaj.org/article/6bcff2133149453ca150abb910cd16f2
Autor:
Angela Hamblin, Sarah Wordsworth, Jilles M Fermont, Suzanne Page, Kulvinder Kaur, Carme Camps, Pamela Kaisaki, Avinash Gupta, Denis Talbot, Mark Middleton, Shirley Henderson, Anthony Cutts, Dimitrios V Vavoulis, Nick Housby, Ian Tomlinson, Jenny C Taylor, Anna Schuh
Publikováno v:
PLoS Medicine, Vol 14, Iss 2, p e1002230 (2017)
BackgroundSingle gene tests to predict whether cancers respond to specific targeted therapies are performed increasingly often. Advances in sequencing technology, collectively referred to as next generation sequencing (NGS), mean the entire cancer ge
Externí odkaz:
https://doaj.org/article/30d53926b96445d9a9f524a7a39674d7
Autor:
Shigenobu Emoto, Joji Kitayama, Hironori Yamaguchi, Hironori Ishigami, Shoichi Kaisaki, Hirokazu Nagawa
Publikováno v:
Case Reports in Oncology, Vol 3, Iss 3, Pp 344-348 (2010)
Objective: Oxygen is one of the most important environmental factors for tumor development. In this study, we examined pO2 in malignant ascites in patients with peritoneal carcinomatosis. Methods: In 21 patients with peritoneal dissemination of gastr
Externí odkaz:
https://doaj.org/article/efc267be337a4391b32b1611934a3692
Autor:
Pamela J Kaisaki, Anthony Cutts, Niko Popitsch, Carme Camps, Melissa M Pentony, Gareth Wilson, Suzanne Page, Kulvinder Kaur, Dimitris Vavoulis, Shirley Henderson, Avinash Gupta, Mark R Middleton, Ioannis Karydis, Denis C Talbot, Anna Schuh, Jenny C Taylor
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162809 (2016)
Use of circulating tumour DNA (ctDNA) as a liquid biopsy has been proposed for potential identification and monitoring of solid tumours. We investigate a next-generation sequencing approach for mutation detection in ctDNA in two related studies using
Externí odkaz:
https://doaj.org/article/c84931d42bd34e6883e57ececea2c9cd
Autor:
Pamela J Kaisaki, Georg W Otto, Joanna F McGouran, Amine Toubal, Karène Argoud, Helen Waller-Evans, Clare Finlay, Sophie Caldérari, Marie-Thérèse Bihoreau, Benedikt M Kessler, Dominique Gauguier, Richard Mott
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94555 (2014)
Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakiz
Externí odkaz:
https://doaj.org/article/df135f88f9f649eaad9b62bf58e4c475