Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kaisa Palmu"'
Autor:
Petja Rosenqvist, Janne J. Mäkinen, Kaisa Palmu, Johanna Jokinen, Ranjit K. Prajapati, Heidi J. Korhonen, Pasi Virta, Georgiy A. Belogurov, Mikko Metsä-Ketelä
Publikováno v:
European Journal of Medicinal Chemistry. 237:114342
Showdomycin produced by Streptomyces showdoensis ATCC 15227 is a C-nucleoside microbial natural product with antimicrobial and cytotoxic properties. The unique feature of showdomycin in comparison to other nucleosides is its maleimide base moiety, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eced7b6e380677f2b18ef8ba142d43b
https://doi.org/10.1016/j.ejmech.2022.114342
https://doi.org/10.1016/j.ejmech.2022.114342
Publikováno v:
Chembiochem : a European journal of chemical biology. 21(21)
Nogalamycin is an anthracycline anti-cancer agent that intercalates into the DNA double helix. The binding is facilitated by two carbohydrate units, l-nogalose and l-nogalamine, that interact with the minor and major grooves of DNA, respectively. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47abecb6db2d10cafceb3b1ee4034ce3
https://pubmed.ncbi.nlm.nih.gov/32557994
https://pubmed.ncbi.nlm.nih.gov/32557994
Autor:
Ranjit K, Prajapati, Petja, Rosenqvist, Kaisa, Palmu, Janne J, Mäkinen, Anssi M, Malinen, Pasi, Virta, Mikko, Metsä-Ketelä, Georgiy A, Belogurov
Publikováno v:
Nucleic Acids Research
Oxazinomycin is a C-nucleoside antibiotic that is produced by Streptomyces hygroscopicus and closely resembles uridine. Here, we show that the oxazinomycin triphosphate is a good substrate for bacterial and eukaryotic RNA polymerases (RNAPs) and that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bec080cd6436812e8bcff49508236dfe
https://pubmed.ncbi.nlm.nih.gov/31495891
https://pubmed.ncbi.nlm.nih.gov/31495891
Autor:
Jarmo Niemi, Kaisa Palmu, Keith Yamada, Mikko Metsä-Ketelä, Ranjit Kumar Prajapati, Petja Rosenqvist, Georgiy A. Belogurov, Pasi Virta
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Pseudouridimycin (PUM), a selective inhibitor of bacterial RNA polymerase has been previously detected in microbial-extracts of two strains of Streptomyces species (strain ID38640 and ID38673). Here, we isolated PUM and its deoxygenated analogue deso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc795e27ea1fb7108906b3fa37273fe
http://europepmc.org/articles/PMC6586884
http://europepmc.org/articles/PMC6586884
Autor:
Georgi A. Belogurov, Yulia Ilina, Janne J. Mäkinen, Keshav Thapa, Mikko Metsä-Ketelä, Pasi Virta, Vilja Siitonen, Kaisa Palmu, Petja Rosenqvist, Jarmo Niemi, Bikash Baral
Publikováno v:
ACS chemical biology. 12(6)
Nucleoside antibiotics are a large class of pharmaceutically relevant chemical entities, which exhibit a broad spectrum of biological activities. Most nucleosides belong to the canonical N-nucleoside family, where the heterocyclic unit is connected t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3793d3ba8156bc7cc7e277296596fe
https://pubmed.ncbi.nlm.nih.gov/28418235
https://pubmed.ncbi.nlm.nih.gov/28418235
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:396-399
Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater . Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene sno aL, encoding a nogalonic acid methyl est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c562577edc33d2e2c0f35f70d588357f
https://doi.org/10.1128/aac.44.2.396-399.2000
https://doi.org/10.1128/aac.44.2.396-399.2000
Publikováno v:
Applied Biochemistry and Biotechnology. 75:307-321
The ligninolytic enzyme system of Phanerochaete chrysosporium is able to decolorize several recalcitrant dyes. Three lignin peroxidase isoenzymes, LiP 3.85, LiP 4.15, and LiP 4.65, were purified by preparative isoelectric focusing from the carbon-lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f760383a0e10899cae90c598bd63d2
https://doi.org/10.1007/bf02787783
https://doi.org/10.1007/bf02787783
Publikováno v:
Protein Expression and Purification. 10:70-79
In this paper we report the expression in Pichia pastoris, purification, and characterization of the Aspergillus awamori glucoamylase catalytical domain (GAc). Pichia pastoris produced GAc to the level of 0.4 g per liter medium. This production level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa11473db72c654331e8b0c47bc4be9f
https://doi.org/10.1006/prep.1996.0713
https://doi.org/10.1006/prep.1996.0713
Publikováno v:
Chembiochem : a European journal of chemical biology. 8(13)
Genome-sequencing projects have revealed that Streptomyces bacteria have the genetic potential to produce considerably larger numbers of natural products than can be observed under standard laboratory conditions. Cryptic angucycline-type aromatic pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fd6af1c2f50c7ee18e974f742bf14c
https://pubmed.ncbi.nlm.nih.gov/17654627
https://pubmed.ncbi.nlm.nih.gov/17654627
Publikováno v:
Protein expression and purification. 12(1)
The soluble form of human placental alkaline phosphatase (PLAP) was expressed in the methylotrophic yeast Pichia pastoris and the expression product was purified and characterized. Yeast-derived PLAP (yPLAP) was secreted into the medium to the level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf9d5bf25a67c81cb8ff0499a554aad
https://pubmed.ncbi.nlm.nih.gov/9473461
https://pubmed.ncbi.nlm.nih.gov/9473461