Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kaisa Pakari"'
Publikováno v:
BIOspektrum. 29:25-28
CRISPR/Cas9 systems and recently established base editors are essential tools for precise, targeted genome editing for translational and basic research applications. Here we present small, easily combined improvements to reach editing versatility and
Publikováno v:
BIOspektrum. 29:280-282
Base editing by CRISPR crucially depends on the presence of a PAM in proper distance to the editing-site. Here we present and validate an efficient one-shot approach termed “inception”, relaxing these constraints. This is achieved by sequential,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4105a1e573c506f90d3a0d1caf4e3bef
https://doi.org/10.1101/2022.07.07.499158
https://doi.org/10.1101/2022.07.07.499158
Autor:
Michael J. Ziegler, Klaus Yserentant, Valentin Dunsing, Volker Middel, Antoni J. Gralak, Kaisa Pakari, Jörn Bargstedt, Christoph Kern, Annett Petrich, Salvatore Chiantia, Uwe Strähle, Dirk-Peter Herten, Richard Wombacher
Publikováno v:
Nature chemical biology, 18 (1), 64–69
Nature Chemical Biology
Nature Chemical Biology
Direct control of protein interactions by chemically induced protein proximity holds great potential for both cell and synthetic biology as well as therapeutic applications. Low toxicity, orthogonality and excellent cell permeability are important cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f423bf487699fc2e13f68004bd2f3d8b
https://publikationen.bibliothek.kit.edu/1000143183/147570161
https://publikationen.bibliothek.kit.edu/1000143183/147570161
Autor:
Clara Becker, Erdmann Rapp, Kaisa Pakari, Valerian Grote, Thomas Thumberger, Thomas Ruppert, Joachim Wittbrodt, Marcus Hoffmann, Roman Sakson, Sevinç Gücüm, Lars Beedgen, Christian Thiel
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
article-version (VoR) Version of Record
Development
Defects in the evolutionarily conserved protein-glycosylation machinery during embryonic development are often fatal. Consequently, congenital disorders of glycosylation (CDG) in human are rare. We modelled a putative hypomorphic mutation described i