Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kaisa M.A. Kurkinen"'
Autor:
Teemu Natunen, Mari Takalo, Susanna Kemppainen, Stina Leskelä, Mikael Marttinen, Kaisa M.A. Kurkinen, Juha-Pekka Pursiheimo, Timo Sarajärvi, Jayashree Viswanathan, Sami Gabbouj, Eino Solje, Eveliina Tahvanainen, Tiina Pirttimäki, Mitja Kurki, Jussi Paananen, Tuomas Rauramaa, Pasi Miettinen, Petra Mäkinen, Ville Leinonen, Hilkka Soininen, Kari Airenne, Rudolph E. Tanzi, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://doaj.org/article/fec99dbad77e483d989eaa39ef52f9e5
Autor:
Mari Takalo, Juha-Pekka Pursiheimo, Jussi Paananen, Tiina Pirttimäki, Eino Solje, Heikki Tanila, Tuomas Rauramaa, Pasi Miettinen, Sami Gabbouj, Rudolph E. Tanzi, Ville Leinonen, Stina Leskelä, Timo Sarajärvi, Teemu Natunen, Mitja I. Kurki, Mikko Hiltunen, Jayashree Viswanathan, Susanna Kemppainen, Annakaisa Haapasalo, Mikael Marttinen, Eveliina Tahvanainen, Kaisa M.A. Kurkinen, Kari J. Airenne, Hilkka Soininen, Petra Mäkinen
Publikováno v:
Neurobiology of Disease, Vol 85, Iss, Pp 187-205 (2016)
Accumulation of β-amyloid (Aβ) and phosphorylated tau in the brain are central events underlying Alzheimer's disease (AD) pathogenesis. Aβ is generated from amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and γ-secretase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c72e0865d092c411e96e238f16d6e1
https://doi.org/10.1016/j.nbd.2015.11.005
https://doi.org/10.1016/j.nbd.2015.11.005
Autor:
Mitja I. Kurki, Anne M. Remes, Anette Hall, Henna Martiskainen, Ville Leinonen, Terho Lehtimäki, Mikko Hiltunen, Anne M. Koivisto, Kari M. Mattila, Hilkka Soininen, Timo Sarajärvi, Marjo Laitinen, Seppo Helisalmi, Petra Mäkinen, Teemu Natunen, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Sanna-Kaisa Herukka, Annakaisa Haapasalo, Jaakko Huovinen
Publikováno v:
Journal of Alzheimer's Disease. 43:565-573
BACKGROUND Several risk loci for Alzheimer's disease (AD) have been identified during recent years in large-scale genome-wide association studies. However, little is known about the mechanisms by which these loci influence AD pathogenesis. OBJECTIVE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb52bb79515c9cabfab4d4dfcb8a0ff
https://doi.org/10.3233/jad-140777
https://doi.org/10.3233/jad-140777
Autor:
Annakaisa Haapasalo, Kaisa M.A. Kurkinen, Seppo Helisalmi, Timo Sarajärvi, Kristina Mullin, Rudolph E. Tanzi, Antonio R. Parrado, Teemu Natunen, Hilkka Soininen, Lars Bertram, Petra Mäkinen, Juha-Pekka Pursiheimo, Mikko Hiltunen, Irina Alafuzoff
Publikováno v:
Journal of Alzheimer's Disease. 37:217-232
Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degradation of BACE1 (beta-site A beta PP-cleaving enzyme), the rate-limiting enzyme in the production of amyloid-beta (A be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a1afe6c85c53f61cebccbb9194dd0
https://doi.org/10.3233/jad-130104
https://doi.org/10.3233/jad-130104
Autor:
Lars Bertram, Kaisa M.A. Kurkinen, Rudolph E. Tanzi, Annakaisa Haapasalo, Jayashree Viswanathan, Petra Mäkinen, Teemu Natunen, Hilkka Soininen, Mikko Hiltunen
Publikováno v:
Biochemistry. 52:3899-3912
Ubiquilin-1 is an Alzheimer's disease-associated protein, which is known to modulate amyloid precursor protein (APP) processing, amyloid-β (Aβ) secretion, and presenilin-1 (PS1) accumulation. Here, we aim to elucidate the molecular mechanisms by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d01886ae95bf1ebc060c3960ebff927
https://doi.org/10.1021/bi400138p
https://doi.org/10.1021/bi400138p
Autor:
Mikko Hiltunen, Kaisa M.A. Kurkinen, Annakaisa Haapasalo, Hilkka Soininen, Jussi Pihlajamäki, Henna Martiskainen
Publikováno v:
Expert Opinion on Therapeutic Targets. 17:781-794
Progressive neuronal loss is a key feature in Alzheimer's disease (AD), which is the most common neurodegenerative disorder in the aging population. Currently, there are no therapeutic means to intervene neuronal damage in AD and therefore innovative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837bb9a898d60acc97ea27b82955374b
https://doi.org/10.1517/14728222.2013.789862
https://doi.org/10.1517/14728222.2013.789862
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1
Autor:
Petra Mäkinen, Heikki Tanila, Tuomas Rauramaa, Hilkka Soininen, Mikko Hiltunen, Ville Leinonen, Sami Gabbouj, Kaisa M.A. Kurkinen, Fanni Haapalinna, Timo Sarajärvi, Laura J. Turner, Teemu Natunen, Mitja I. Kurki, Annakaisa Haapasalo, Jussi Paananen, Mikael Marttinen, Anne M. Koivisto, Fiona R. Lucas
Publikováno v:
Journal of cell science. 129(11)
Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88edb67fea49ee010e9e3b03272e9f9a
https://pubmed.ncbi.nlm.nih.gov/27084579
https://pubmed.ncbi.nlm.nih.gov/27084579
Autor:
Annakaisa Haapasalo, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Lars Bertram, Hilkka Soininen, Nico P. Dantuma, Rudolph E. Tanzi, Mikko Hiltunen
Publikováno v:
Communicative & Integrative Biology. 4:428-432
Controlled management of protein levels and quality is essential for normal cellular function. Specific molecular chaperones and foldases monitor the levels and assist correct folding of proteins. The ubiquitin-proteasome system recognizes and degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ca382eeb81bd599405d5fe690b2bea
https://doi.org/10.4161/cib.15283
https://doi.org/10.4161/cib.15283
Autor:
Christa J. Maynard, Bradley T. Hyman, Nico P. Dantuma, Hilkka Soininen, Anne V. Thomas, Claudia Böttcher, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Lars Bertram, Alice Lu, Rudolph E. Tanzi, Mikko Hiltunen, Annakaisa Haapasalo, Oksana Berezovska, Donna M. Romano, Riitta Miettinen
Publikováno v:
Traffic. 12:330-348
The Alzheimer's disease (AD)-associated ubiquilin-1 regulates proteasomal degradation of proteins, including presenilin (PS). PS-dependent γ-secretase generates β-amyloid (Aβ) peptides, which excessively accumulate in AD brain. Here, we have chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407bafe41212902ced09109ef2411626
https://doi.org/10.1111/j.1600-0854.2010.01149.x
https://doi.org/10.1111/j.1600-0854.2010.01149.x
Autor:
Juha E. Jääskeläinen, Henri J. Huttunen, Irina Alafuzoff, Seppo Helisalmi, Timo Sarajärvi, Kaisa M.A. Kurkinen, Jayashree Viswanathan, Hilkka Soininen, Ville Leinonen, Juha-Pekka Pursiheimo, Mikko Hiltunen, Annakaisa Haapasalo, Henna Martiskainen, Mitja I. Kurki, Tuomas Rauramaa, Niko-Petteri Nykänen, Teemu Natunen
Publikováno v:
Neurobiology of aging. 36(2)
In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease (AD) in the postmortem inferior temporal cortex samples obtained from 60 subjects with varying degre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9dfdfce0b142cc36fc7e2d01320ae7
https://pubmed.ncbi.nlm.nih.gov/25281018
https://pubmed.ncbi.nlm.nih.gov/25281018