Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kaisa Hellevuo"'
Publikováno v:
Journal of Biological Chemistry. 278:4552-4560
Ethanol can enhance Gsα-stimulated adenylyl cyclase (AC) activity. Of the nine isoforms of AC, type 7 (AC7) is the most sensitive to ethanol. The potentiation of AC7 by ethanol is dependent on protein kinase C (PKC). We designed studies to determine
Publikováno v:
Journal of Neurochemistry. 67:177-185
RNase protection assays were used in a comparative analysis of the quantities of mRNA for five "calcium-sensitive" (types I, III, V, VI, and VIII) adenylyl cyclases and one "calcium-insensitive" (type II) adenylyl cyclase in mouse cerebral cortex, ce
Publikováno v:
American Journal of Medical Genetics. 74:95-98
Platelet adenylyl cyclase activity has been proposed as a trait marker for alcoholism [Tabakoff et al. (1988): N Engl J Med 318:134–139; Parsian et al. (1996): Alcohol Clin Exp Res 20:745–751]. Human adenylyl cyclase type 7 (ADCY7) is a member of
Publikováno v:
Alcoholism: Clinical and Experimental Research. 18:410-414
Ethanol-dependent mice were treated with the 5-HT3 antagonist MDL 72222 after withdrawal from ethanol. Treatment with unit doses (0, 5.6, 10, and 17.0 mg/kg) of MDL 72222 at 0, 4, and 7 hr after withdrawal dose-dependently exacerbated the severity of
Publikováno v:
Alcohol. 7:159-163
The importance of the central catecholamines, with the emphasis on the noradrenergic neurons in the differential sensitivity to ethanol between the AT (alcohol-tolerant) rats selected for low and the ANT (alcohol-nontolerant) rats selected for high s
Publikováno v:
The Journal of biological chemistry. 278(7)
Ethanol can enhance G(salpha)-stimulated adenylyl cyclase (AC) activity. Of the nine isoforms of AC, type 7 (AC7) is the most sensitive to ethanol. The potentiation of AC7 by ethanol is dependent on protein kinase C (PKC). We designed studies to dete
Publikováno v:
Journal of biomedical science. 8(1)
Our studies indicate that, in the presence of particular isoforms of adenylyl cyclase (i.e., type 7 AC), moderately intoxicating concentrations of ethanol will significantly potentiate transmitter-mediated activation of the cAMP signaling cascade. Ac
Autor:
Kaisa Hellevuo, Boris Tabakoff, Nicole Mons, Paula L. Hoffman, Masami Yoshimura, Dermot M.F. Cooper
Publikováno v:
The Journal of biological chemistry. 270(19)
We characterized a human cDNA clone which encodes a novel adenylyl cyclase. Data from Southern and Northern blot analysis, and analysis of sequence similarity with a recently cloned mouse adenylyl cyclase (10), indicated that the human adenylyl cycla
Publikováno v:
Human genetics. 95(2)
A novel form of human adenylyl cyclase (ADCY7) has been discovered in the human erythroleukemia cell line (HEL). This cell line has been widely used as a model for studies of the characteristics of human platelets. Data from HEL cells suggests that A
Autor:
Masami Yoshimura, Dermot M.F. Cooper, Kaisa Hellevuo, M. Kao, Paula L. Hoffman, Boris Tabakoff
Publikováno v:
Biochemical and biophysical research communications. 192(1)
The polymerase chain reaction (PCR) was used to detect several forms of adenylyl cyclase (AC′s) expressed in human erythroleukemia (HEL) cells. Degenerate oligonucleotide primers were synthesized based on the conserved sequences in the C2a area of