Výsledky vyhledávání - "Kaisa Haglund"

Akademický článek

ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo.

Autor: Åsmund H Eikenes, Lene Malerød, Anette Lie Christensen, Chloé B Steen, Juliette Mathieu, Ioannis P Nezis, Knut Liestøl, Jean-René Huynh, Harald Stenmark, Kaisa Haglund

Publikováno v: PLoS Genetics, Vol 11, Iss 1, p e1004904 (2015)

Abscission is the final step of cytokinesis that involves the cleavage of the intercellular bridge connecting the two daughter cells. Recent studies have given novel insight into the spatiotemporal regulation and molecular mechanisms controlling absc

Externí odkaz: https://doaj.org/article/44fafa45af4b4a64878756d7f624046a

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Akademický článek

A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis.

Autor: Antonia P Sagona, Ioannis P Nezis, Kristi G Bache, Kaisa Haglund, Anne Cathrine Bakken, Rolf I Skotheim, Harald Stenmark

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17086 (2011)

The tumor suppressor activity of Beclin 1 (BECN1), a subunit of class III phosphatidylinositol 3-kinase complex, has been attributed to its regulation of apoptosis and autophagy. Here, we identify FYVE-CENT (ZFYVE26), a phosphatidylinositol 3-phospha

Externí odkaz: https://doaj.org/article/f567135b8a074e6ea02fbb7fabd51377

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Akademický článek

Disruption of Vps4 and JNK function in Drosophila causes tumour growth.

Autor: Lina M Rodahl, Kaisa Haglund, Catherine Sem-Jacobsen, Franz Wendler, Jean-Paul Vincent, Karine Lindmo, Tor Erik Rusten, Harald Stenmark

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4354 (2009)

Several regulators of endocytic trafficking have recently been identified as tumour suppressors in Drosophila. These include components of the endosomal sorting complex required for transport (ESCRT) machinery. Disruption of subunits of ESCRT-I and -

Externí odkaz: https://doaj.org/article/f1c322d7f63f4ff49599ee8322186513

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Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

Autor: Sascha Pust, Andreas Brech, Catherine Sem Wegner, Harald Stenmark, Kaisa Haglund

Cellular abscission is the final step of cytokinesis that leads to the physical separation of the two daughter cells. The scaffold protein ALIX and the ESCRT-I protein TSG101 contribute to recruiting ESCRT-III to the midbody, which orchestrates the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e37f850c05689871885f8f5c2072912a
https://doi.org/10.1101/2022.11.22.517322

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Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding

Autor: Kia Wee Tan, Lene Malerød, Ashish Jain, Kristina Ivanauskiene, Anette Lie-Jensen, Harald Stenmark, Kaisa Haglund, Knut Liestøl, Jon K. Laerdahl

Publikováno v: Current biology : CB. 29(20)

Summary Abscission, the final step of cytokinesis, cleaves the thin intercellular bridge connecting the two daughter cells [1–6]. The scaffold protein ALIX is a core component of the abscission machinery with an evolutionarily conserved role in mid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f7222d5a8bd54c42602051e6b56b4c
https://pubmed.ncbi.nlm.nih.gov/31639350

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Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics

Autor: Lene Malerød, Åsmund Husabø Eikenes, Kaisa Haglund, Anette Lie-Jensen, Knut Liestøl, Harald Stenmark, Andreas Brech, Roland Le Borgne

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2018, 37 (13), pp.e97741. ⟨10.15252/embj.201797741⟩
EMBO Journal, 2018, 37 (13), pp.e97741. ⟨10.15252/embj.201797741⟩
EMBO Journal, 2018, 〈10.15252/embj.201797741〉

International audience; The orientation of the mitotic spindle (MS) is tightly regulated, but the molecular mechanisms are incompletely understood. Here we report a novel role for the multifunctional adaptor protein ALG-2-interacting protein X (ALIX)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9651227a7c8e394ced61cfaadb5f53
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01812517

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Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring

Autor: Yusuke Takatsuru, Ryosuke Kaneko, Shinnosuke Masuda, Tomoko Sairenji, Kaisa Haglund, Izuki Amano, Kaoru Uchida, Jun Ikezawa, Kazutoshi Sayama, Hiroko Masuda, Ivan Dikic, Yurie Takanashi, Taku James Sairenji, Noriyuki Koibuchi, Noriaki Shimokawa

Although maternal nurturing behavior is extremely important for the preservation of a species, our knowledge of the biological underpinnings of these behaviors is insufficient. Here we show that the degree of a mother's nurturing behavior is regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb2455e43e225178a3afb9f15f6d471
https://europepmc.org/articles/PMC5724246/

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Investigating spermatogenesis in Drosophila melanogaster

Autor: Rafael Sênos Demarco, D. Leanne Jones, Åsmund Husabø Eikenes, Kaisa Haglund

Publikováno v: Methods. 68:218-227

The process of spermatogenesis in Drosophila melanogaster provides a powerful model system to probe a variety of developmental and cell biological questions, such as the characterization of mechanisms that regulate stem cell behavior, cytokinesis, me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dcc2dd95e0d5741290b5206a5c3fe6
https://doi.org/10.1016/j.ymeth.2014.04.020

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Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages

Autor: Odile Sergent, James J. Pestka, Dominique Lagadic-Gossmann, Kaisa Haglund, Jørn A. Holme, Anita Solhaug, Béatrice Dendelé, Gunnar Sundstøl Eriksen

Publikováno v: Toxicology Letters
Toxicology Letters, 2013, 219 (1), pp.8-17. ⟨10.1016/j.toxlet.2013.02.012⟩
Toxicology Letters, Elsevier, 2013, 219 (1), pp.8-17. ⟨10.1016/j.toxlet.2013.02.012⟩

International audience; The mycotoxin alternariol (AOH), a frequent contaminant in fruit and cereal products, is known to induce DNA damage with subsequent cell cycle arrest. Here we elucidated the effects of AOH on stages of cell cycle progression u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e794c51325f77bda09d87f39d9e3caff
https://doi.org/10.1016/j.toxlet.2013.02.012

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Antibody Staining in Drosophila Germaria

Autor: Anette, Lie-Jensen, Kaisa, Haglund

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1457

Drosophila oogenesis is a powerful model for studying a wide spectrum of cellular and developmental processes in vivo. Oogenesis starts in a specialized structure called the germarium, which harbors the stem cells for both germ and somatic cells. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40e34be5e139f01e62f6b14863f4525e
https://pubmed.ncbi.nlm.nih.gov/27557571

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