Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.

Autor: Angeliki Korpetinou, Spyros S Skandalis, Aristidis Moustakas, Kaisa E Happonen, Heidi Tveit, Kristian Prydz, Vassiliki T Labropoulou, Efstathia Giannopoulou, Haralambos P Kalofonos, Anna M Blom, Nikos K Karamanos, Achilleas D Theocharis

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78157 (2013)

Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first time the in situ expression of serglycin by breast cancer c

Externí odkaz: https://doaj.org/article/bf6fc88ee0a84e568468f5250fae9219

Tyro3 promotes the maturation of glutamatergic synapses

Autor: Sheng Miao, Lawrence Fourgeaud, Patrick G. Burrola, Shani Stern, Yuhan Zhang, Kaisa E. Happonen, Sammy Weiser Novak, Fred H. Gage, Greg Lemke

Publikováno v: Frontiers in Neuroscience, Vol 18 (2024)

The receptor tyrosine kinase Tyro3 is abundantly expressed in neurons of the neocortex, hippocampus, and striatum, but its role in these cells is unknown. We found that neuronal expression of this receptor was markedly up-regulated in the postnatal m

Externí odkaz: https://doaj.org/article/9dfa132aca1f49d292b45beb70f65c78

Microglia use TAM receptors to detect and engulf amyloid beta plaques

Autor: Greg Lemke, Patrick Burrola, Kaisa E. Happonen, Nasun Hah, Youtong Huang, Ling Huang, Axel Nimmerjahn, Carolyn O’Connor

Publikováno v: Nature immunology

Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer’s disease and its mouse models, induced expression of Ax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee20c04f15cc8b45604686200c8c4ad3
http://europepmc.org/articles/PMC8102389

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

Autor: Elena Alberdi, Beáta Sperlágh, Angela Schulz, Irune Diaz-Aparicio, Noelia Rodríguez-Iglesias, Paloma Huguet, Mirjana Maletic-Savatic, Sol Beccari, Oihane Abiega, Jorge Valero, Mar Márquez-Ropero, Ainhoa Plaza-Zabala, Lilla Otrokocsi, Iñaki Paris, Amanda Sierra, Virginia Sierra-Torre, Kaisa E. Happonen, Greg Lemke, Carlos Matute, Irantzu Bernales

Publikováno v: The Journal of Neuroscience

During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf31522adf46140a2192d86f094b95d
https://pubmed.ncbi.nlm.nih.gov/31896673

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles

Autor: Kaisa E. Happonen, Sinh Tran, Raja Prince, Anne Angelillo-Scherrer, Sara Calzavarini, Matthias Mörgelin, Björn Dahlbäck

Publikováno v: Happonen, Kaisa E; Tran, Sinh; Morgelin, Matthias; Prince, Raja; Calzavarini, Sara; Angelillo, Anne; Dahlback, Bjorn (2016). The Gas6-Axl Interaction Mediates Endothelial Uptake of Platelet Microparticles. Journal of biological chemistry, 291(20), pp. 10586-10601. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M115.699058

Upon activation, platelets release plasma membrane-derived microparticles (PMPs) exposing phosphatidylserine on their surface. The functions and clearance mechanism of these microparticles are incompletely understood. As they are pro-coagulant and po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31f72ec4323331711961b4f068aa577
https://doi.org/10.1074/jbc.m115.699058