Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kaisa Piipari"'
PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice
Autor:
Emma Deas, Kaisa Piipari, Asif Machhada, Abi Li, Ana Gutierrez-del-Arroyo, Dominic J. Withers, Nicholas W. Wood, Andrey Y. Abramov
Publikováno v:
Open Biology, Vol 4, Iss 5 (2014)
The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function
Externí odkaz:
https://doaj.org/article/8a2b0a727515409392cfb6a3ef10f58c
Autor:
Elaine E. Irvine, Mark A. Smith, Michael L.J. Ashford, Colin Selman, Melanie Clements, Rachel L. Batterham, Hind Al-Qassab, Jimmy D. Bell, Bart Vanhaesebroeck, Agharul I. Choudhury, Dominic J. Withers, Julie Guillermet-Guibert, Keval Chandarana, Andrew J.H. Smith, Gregory S. Barsh, Kaisa Piipari, Marc Claret, Steven J. Lingard
Publikováno v:
Cell Metabolism
Al-Qassab, H, Smith, M A, Irvine, E E, Guillermet-Guibert, J, Claret, M, Choudhury, A I, Selman, C, Piipari, K, Clements, M, Lingard, S, Chandarana, K, Bell, J D, Barsh, G S, Smith, A, Batterham, R L, Ashford, M L J, Vanhaesebroeck, B & Withers, D J 2009, ' Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons ', Cell Metabolism, vol. 10, no. 5, pp. 343-354 . https://doi.org/10.1016/j.cmet.2009.09.008
Al-Qassab, H, Smith, M A, Irvine, E E, Guillermet-Guibert, J, Claret, M, Choudhury, A I, Selman, C, Piipari, K, Clements, M, Lingard, S, Chandarana, K, Bell, J D, Barsh, G S, Smith, A, Batterham, R L, Ashford, M L J, Vanhaesebroeck, B & Withers, D J 2009, ' Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons ', Cell Metabolism, vol. 10, no. 5, pp. 343-354 . https://doi.org/10.1016/j.cmet.2009.09.008
PI3K signaling is thought to mediate leptin and insulin action in hypothalamic pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, through largely unknown mechanisms. We inactivated either p110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5655d14ac7acd1e232476b8d67720b8
http://europepmc.org/articles/PMC2806524
http://europepmc.org/articles/PMC2806524
Autor:
Patrice D. Cani, Marco Peters, Dominic J. Withers, Rachel L. Batterham, Alan Ashworth, Claude Knauf, Anne White, Rémy Burcelin, Philippe Valet, André Colom, Kaisa Piipari, Hind Al-Qassab, Angela Woods, K. Peter Giese, Ghazala Begum, Amanda Heslegrave, Michael L.J. Ashford, Mark A. Smith, Marc Claret, Keiko Mizuno, Phillip Mucket, David Carling, Julian J. Emmanuel
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2011, 60 (3), pp.735-45. ⟨10.2337/db10-1055⟩
Diabetes, Vol. 60, no. 3, p. 735-745 (2011)
Diabetes, 2011, 60 (3), pp.735-45. ⟨10.2337/db10-1055⟩
Diabetes, American Diabetes Association, 2011, 60 (3), pp.735-45. ⟨10.2337/db10-1055⟩
Diabetes, Vol. 60, no. 3, p. 735-745 (2011)
Diabetes, 2011, 60 (3), pp.735-45. ⟨10.2337/db10-1055⟩
OBJECTIVE AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons causes obesity and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b9929b9b68df00fffbfba6e8175690
https://www.hal.inserm.fr/inserm-00615232
https://www.hal.inserm.fr/inserm-00615232
Autor:
Dominic J. Withers, Benoit Viollet, Kaisa Piipari, Michael L.J. Ashford, David Carling, Craig Beall, Nadeene Parker, Hind Al-Qassab, Mark A. Smith
Publikováno v:
Biochemical Journal
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear. In the present study, we therefore investigated whether AMPK plays a critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d456e9d47ca024276f0a953512745795
https://pubmed.ncbi.nlm.nih.gov/20465544
https://pubmed.ncbi.nlm.nih.gov/20465544
PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice
Autor:
Dominic J. Withers, Emma Deas, Ana Gutierrez-del-Arroyo, Abi Li, Kaisa Piipari, Asif Machhada, Andrey Y. Abramov, Nicholas W. Wood
Publikováno v:
Open Biology, Vol 4, Iss 5 (2014)
Open Biology
Open Biology
The Parkinson's disease (PD) gene, PARK6 , encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86494c5e0315c009a7238c2d663e36a2
https://doi.org/10.1098/rsob.140051
https://doi.org/10.1098/rsob.140051
Autor:
Craig Beall, Kaisa Piipari, Hind Al‑Qassab, Nadeene Parker, David Carling, Benoit Viollet, Dominic J. Withers, Michael L. J. Ashford
Publikováno v:
Biochemical Journal; Jun2010, Vol. 429 Issue 2, p323-333, 11p