Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kairui Yue"'
Autor:
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Publikováno v:
Journal of Medicinal Chemistry. 65:285-302
As "Michael acceptors" may induce promiscuous responses in mammalian cells by reacting with various proteins, we modified the cinnamamide of our previous hydrazide-based HDAC inhibitors (HDACIs) to deactivate the Michael reaction. Representative comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c3507991748b853e49350dd1fdf2bd
https://doi.org/10.1021/acs.jmedchem.1c01472
https://doi.org/10.1021/acs.jmedchem.1c01472
Autor:
Jiangkun Yan, Kairui Yue, Xuejing Fan, Ximing Xu, Jing Wang, Mengting Qin, Qianer Zhang, Xiaohan Hou, Xiaoyang Li, Yong Wang
Publikováno v:
European journal of medicinal chemistry. 246
Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes and emerges as a promising target for treating cancer and neurodegenerative diseases. Benefited from the unique sandwich conformation of ferrocene, a series of ferrocene-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26add19cb71a14c4e20e0ee939fc12dd
https://pubmed.ncbi.nlm.nih.gov/36516583
https://pubmed.ncbi.nlm.nih.gov/36516583
Autor:
Kairui Yue, Simin Sun, Geng Jia, Mengting Qin, Xiaohan Hou, C. James Chou, Chao Huang, Xiaoyang Li
Publikováno v:
Journal of medicinal chemistry. 65(18)
In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which displays superior pharmacokinetic properties to the current hydroxamic acid inhibitors. Structure-activity relationship study re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d98ffa14285e258dc8e89704a336b2
https://pubmed.ncbi.nlm.nih.gov/36073117
https://pubmed.ncbi.nlm.nih.gov/36073117
Publikováno v:
Bioorganicmedicinal chemistry letters. 70
Hydroxamic acid and benzamide are the most commonly used zinc binding group (ZBG) for HDAC inhibitors both in clinic and pre-clinic. Recently, we discovered several analogs of new type HDAC inhibitors with hydrazide as ZBG. Representative compounds d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5720c3ce131423d6091da9833e0632
https://pubmed.ncbi.nlm.nih.gov/35580726
https://pubmed.ncbi.nlm.nih.gov/35580726
Autor:
Kairui Yue, Chen Xu, Zhihao Wang, Wandong Liu, Chenyu Liu, Ximing Xu, Yan Xing, Sheng Chen, Xiaoyang Li, Shengbiao Wan
Publikováno v:
Bioorganic Chemistry. 129:106153
The New Delhi β-Lactamase 1 (NDM-1), one of the most prevalent types of metallo-β-lactamases, has attracted extensive attention since its discovery. Extensive efforts have been made to develop inhibitor of NDM-1, however, no inhibitor is available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b401a792d134d2c4e84773a0b9d4a2d
https://doi.org/10.1016/j.bioorg.2022.106153
https://doi.org/10.1016/j.bioorg.2022.106153
Autor:
Kairui Yue, Jiang Yuqi, Xuejian Wang, Wenfang Xu, Liang Zhang, Peixia Li, Jian Zhang, Xiaohan Hou, Geng Jia, Zhaolin Zhang, Leqiao Tan, Li Xiaoyang
Publikováno v:
Bioorganic chemistry. 116
In our previous study, we discovered a ubenimex-fluorouracil (5FU) conjugates BC-02, which displays significant in vivo anti-tumor activity, however, the instability of BC-02 in plasma limits its further development as a drug candidate. Herein, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c633861e44e3949ef59234ba3f10ddde
https://pubmed.ncbi.nlm.nih.gov/34544027
https://pubmed.ncbi.nlm.nih.gov/34544027
Autor:
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, Chou, C. James, Xiaoyang Li
Publikováno v:
Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p285-302, 18p