Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS‐CoV‐2

Autor: Russell M. Petrak, Nathan C. Skorodin, Nicholas W. Van Hise, Robert M. Fliegelman, Jonathan Pinsky, Vishal Didwania, Michael Anderson, Melina Diaz, Kairav Shah, Vishnu V. Chundi, David W. Hines, Brian P. Harting, Kamo Sidwha, Brian Yu, Paul Brune, Anjum Owaisi, David Beezhold, Joseph Kent, Dana Vais, Alice Han, Neethi Gowda, Nishi Sahgal, Jan Silverman, Jonathan Stake, Jenie Nepomuceno, Renuka Heddurshetti

Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2146-2151 (2021)

Tocilizumab is an IL‐6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2). We evaluated patients treated with tocilizumab f

Externí odkaz: https://doaj.org/article/8f2e979c953546579043c6871302879b

A Real-World Assessment of Clinical Outcomes and Safety of Eravacycline: A Novel Fluorocycline

Autor: Nicholas Van Hise, Russell M. Petrak, Nathan C. Skorodin, Robert M. Fliegelman, Michael Anderson, Vishal Didwania, Alice Han, Kairav Shah, Vishnu Chundi, David Hines, Ingrid Roig, Apoorv Kalra

Publikováno v: Infectious Diseases and Therapy, Vol 9, Iss 4, Pp 1017-1028 (2020)

Abstract Background Eravacycline is a novel fluorocycline approved for treatment of intraabdominal infections, with a broad spectrum of activity against a range of pathogens including multidrug-resistant species, including ESBL- or KPC-producing isol

Externí odkaz: https://doaj.org/article/0987ea1645524e0dbc5d99cb852cc06b

Successful Treatment of Clostridium difficile Bacteremia with Aortic Mycotic Aneurysm in a Patient with Prior Endovascular Aortic Aneurysm Repair

Autor: Kairav Shah, Rebecca Brauch, Kartikeya Cherabuddi

Publikováno v: Case Reports in Infectious Diseases, Vol 2017 (2017)

The clinical spectrum of Clostridium difficile infection can range from benign gastrointestinal colonization to mild diarrhea and life threatening conditions such as pseudomembranous colitis and toxic megacolon. Extraintestinal manifestations of C. d

Externí odkaz: https://doaj.org/article/7e14c504e413403a83668180667797a5

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

Autor: Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I. Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M. Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L. Modlin, Ryan C. Fields, Robert D. Schreiber, Paul M. Allen, Eynav Klechevsky

Publikováno v: He, M, Roussak, K, Ma, F, Borcherding, N, Garin, V, White, M, Schutt, C, Jensen, T I, Zhao, Y, Iberg, C A, Shah, K, Bhatia, H, Korenfeld, D, Dinkel, S, Gray, J, Ulezko Antonova, A, Ferris, S, Donermeyer, D, Lindestam Arlehamn, C, Gubin, M M, Luo, J, Gorvel, L, Pellegrini, M, Sette, A, Tung, T, Bak, R, Modlin, R L, Fields, R C, Schreiber, R D, Allen, P M & Klechevsky, E 2023, ' CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses ', Science, vol. 379, no. 6633, eabg2752 . https://doi.org/10.1126/science.abg2752

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph node

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb58f3075eb648887329399a6257400
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html

Chronic Osteomyelitis in Sacral Pressure Ulcers Management Review in QA Format

Autor: Vishal Didwania, Nicholas W. Van Hise, Kairav Shah

Publikováno v: Private Practice Infectious Disease. 1

Most cases of reported osteomyelitis in stage 4 pressure ulcers are almost exclusively chronic and superficial (when depth is reported). Wound cultures or bone specimen cultures lack diagnostic sensitivity or specificity. Histopathological diagnosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e71f3745c41a3902185d01575b16aad8
https://doi.org/10.35995/ppid1010002