Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits

Autor: Marilia N. N. Lima, Gustavo C. Cassiano, Kaira C. P. Tomaz, Arthur C. Silva, Bruna K. P. Sousa, Leticia T. Ferreira, Tatyana A. Tavella, Juliana Calit, Daniel Y. Bargieri, Bruno J. Neves, Fabio T. M. Costa, Carolina Horta Andrade

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

Malaria is a tropical infectious disease that affects over 219 million people worldwide. Due to the constant emergence of parasitic resistance to the current antimalarial drugs, the discovery of new antimalarial drugs is a global health priority. Mul

Externí odkaz: https://doaj.org/article/564558e3612b429382d8340316d45acd

Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

Autor: Fabio T. M. Costa, Júlio César Borges, Elizabeth Bilsland, Antonio P. Camargo, Carolina Horta Andrade, Diana Fontinha, Letícia Tiburcio Ferreira, Natalie J. Spillman, Miguel Prudêncio, Per Sunnerhagen, Djane Clarys Baia da Silva, Stefanie C. P. Lopes, Ana Carolina A. V. Kayano, Pedro Cravo, Bruno J. Neves, Marcelo Falsarella Carazzolle, Ludimila Dias Almeida, Kaira C. P. Tomaz, Luis Carlos Salazar Alvarez, Marcus V. G. Lacerda, Leann Tilley, Adrielle Ayumi de Vasconcelos, Daniel Y. Bargieri, Noeli Soares Melo da Silva, Tatyana Almeida Tavella, Gustavo Capatti Cassiano

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ACS Infectious Diseases

Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950b53ad06dafb8e88ef50f1b34dfcc8
https://doi.org/10.1021/acsinfecdis.0c00454

Correction for Ferreira et al., 'Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax'

Autor: Fabio T. M. Costa, Carolina Horta Andrade, Juliana Calit, Letícia Tiburcio Ferreira, Bruno J. Neves, Melina Mottin, Daniel Y. Bargieri, Per Sunnerhagen, Macejane Ferreira Souza, Gustavo Capatti Cassiano, Maria Carolina Silva de Barros Puça, Marilia N. N. Lima, Juliana Rodrigues, Ludimila Dias Almeida, Kaira C. P. Tomaz, Elizabeth Bilsland, Pedro Cravo, Tatyana Almeida Tavella, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Gisely Cardoso de Melo, Djane Clarys Baia-da-Silva

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrob Agents Chemother

Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduce costs, ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca51304feb06f52ce1917ed418a6d57
https://pubmed.ncbi.nlm.nih.gov/32601162

Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits

Autor: Letícia Tiburcio Ferreira, Carolina Horta Andrade, Bruno J. Neves, Bruna Katiele de Paula Sousa, Kaira C. P. Tomaz, Juliana Calit, Tatyana Almeida Tavella, Arthur C. Silva, Daniel Y. Bargieri, Gustavo Capatti Cassiano, Fabio T. M. Costa, Marilia N. N. Lima

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)
Frontiers in Chemistry

Malaria is a tropical infectious disease that affects over 219 million people worldwide. Due to the constant emergence of parasitic resistance to the current antimalarial drugs, the discovery of new antimalarial drugs is a global health priority. Mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c739e17bbf77c2006608aa01bc149a8b
https://www.frontiersin.org/article/10.3389/fchem.2019.00773/full