Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias.

Autor: Stanek M; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany., Picard LP; Institute for Research in Immunology and Cancer (IRIC), Department of Biochemistry and Molecular Medicine , University of Montreal , Québec H3C 3J7 , Canada., Schmidt MF; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany., Kaindl JM; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany., Hübner H; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany., Bouvier M; Institute for Research in Immunology and Cancer (IRIC), Department of Biochemistry and Molecular Medicine , University of Montreal , Québec H3C 3J7 , Canada., Weikert D; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany., Gmeiner P; Department of Chemistry and Pharmacy, Medicinal Chemistry , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Nikolaus-Fiebiger-Str. 10 , Erlangen 91058 , Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 May 23; Vol. 62 (10), pp. 5111-5131. Date of Electronic Publication: 2019 May 13.

Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level.

Autor: Tabor A; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Weisenburger S; Max Planck Institute for the Science of Light and Department of Physics, Friedrich-Alexander University, Günther-Scharowsky-Straße 1/ Bldg. 24, 91058 Erlangen, Germany., Banerjee A; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Purkayastha N; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Kaindl JM; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Hübner H; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Wei L; Max Planck Institute for the Science of Light and Department of Physics, Friedrich-Alexander University, Günther-Scharowsky-Straße 1/ Bldg. 24, 91058 Erlangen, Germany., Grömer TW; Department of Psychiatry and Psychotherapy, Friedrich-Alexander University, Schwabachanlage 6, 91054 Erlangen, Germany., Kornhuber J; Department of Psychiatry and Psychotherapy, Friedrich-Alexander University, Schwabachanlage 6, 91054 Erlangen, Germany., Tschammer N; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany., Birdsall NJ; The Francis Crick Institute, Mill Hill Laboratory, Mill Hill, London NW7 1AA, UK., Mashanov GI; The Francis Crick Institute, Mill Hill Laboratory, Mill Hill, London NW7 1AA, UK., Sandoghdar V; Max Planck Institute for the Science of Light and Department of Physics, Friedrich-Alexander University, Günther-Scharowsky-Straße 1/ Bldg. 24, 91058 Erlangen, Germany., Gmeiner P; Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, 91052 Erlangen, Germany.

Publikováno v: Scientific reports [Sci Rep] 2016 Sep 12; Vol. 6, pp. 33233. Date of Electronic Publication: 2016 Sep 12.

Optical approaches for single-cell and subcellular analysis of GPCR–G protein signaling.

Autor: Kankanamge, Dinesh¹ (AUTHOR), Ratnayake, Kasun¹ (AUTHOR), Senarath, Kanishka¹ (AUTHOR), Tennakoon, Mithila¹ (AUTHOR), Harmon, Elise¹ (AUTHOR), Karunarathne, Ajith¹ (AUTHOR) Ajith.karunarathne@utoledo.edu

Publikováno v: Analytical & Bioanalytical Chemistry. Jul2019, Vol. 411 Issue 19, p4481-4508. 28p.

Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus.

Autor: Quoc Nguyen, Khanh Dinh, Vigers, Michael, Sefah, Eric, Seppälä, Susanna, Hoover, Jennifer Paige, Schonenbach, Nicole Star, Mertz, Blake, O’Malley, Michelle Ann, Han, Songi

Publikováno v: eLife; 8/2/2021, p1-27, 27p

G Protein–Coupled Receptor Pharmacology at the Single-Molecule Level.

Autor: Calebiro, Davide, Grimes, Jak

Publikováno v: Annual Review of Pharmacology & Toxicology; Jan2020, Vol. 60, p73-87, 11p