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Supplemental Figure 1-8 from Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers

Autor: Jing Wang, Ali Fattaey, Jaye L. Viner, David P. Tuck, Troy Patterson, Guang-Xin Xu, Anna W. Ma, Maria Elena S. Samson, Steven Dellarocca, Mylissa A. Borek, Ruzanna Atoyan, Kaiming Sun

Supplemental Figure S1. Protein level changes induced by CUDC-907, panobinostat, or pictilisib in MYC-altered DLBCL cell lines; Supplemental Figure S2. CUDC-907 induced changes in WSU DLCL2 cells; Supplemental Figure S3. CUDC-907 changes the mRNA exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0819bb72cc77df80bf2d29af33bb24d0
https://doi.org/10.1158/1535-7163.22503451.v1

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Abstract P5-13-21: Relationship between circulating tumor DNA and response to neoadjuvant niraparib in HER2-negative, BRCA-mutated breast cancer

Autor: Ming Shan, Laura Spring, Minetta C Liu, Erika Hamilton, Hanna Irie, Cesar A Santa-Maria, Steven J Isakoff, James Reeves, Leif W Ellisen, Lee P Lim, Kavita Garg, Caterina Bertucci, Bin Feng, Hailei Zhang, Kaiming Sun, Julie R Graham, Erin Hofstatter, Hyo Han

Publikováno v: Cancer Research. 82:P5-13

Background: Survival advantages with neoadjuvant chemotherapy (NACT) have been observed in patients (pts) with locally advanced breast cancer (BC) who achieve pathological complete response (pCR). Predicting risk of early recurrence in pts without pC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d433818ad0f4484c82ea9f61375c3c06
https://doi.org/10.1158/1538-7445.sabcs21-p5-13-21

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The distribution of phytoplankton size and major influencing factors in the surface waters near the northern end of the Antarctic Peninsula

Autor: Lu Liu, Qinzeng Xu, Zongling Wang, Xuelei Zhang, Mingzhu Fu, Kaiming Sun, Zongjun Xu

Publikováno v: Acta Oceanologica Sinica. 40:92-99

The waters near the Antarctic Peninsula have always been a study hot spot because of their variable and unique oceanographic conditions. To determine the distribution and possible influencing factors on phytoplankton size and abundance near the Antar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e111ec0963e5a7c9f4eb296ad05cf8c1
https://doi.org/10.1007/s13131-020-1611-3

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Buoyancy potential of dominant green macroalgal species in the Yellow Sea's green tides, China

Autor: Kaiming Sun, Hongbin Han, Jie Xiao, Zongling Wang, Wei Song, Mingzhu Fu, Shiliang Fan, Songdong Shen

Publikováno v: Marine Pollution Bulletin. 140:301-307

Large-scale green tides caused by Ulva prolifera, occurred for 12 consecutive years in the Yellow Sea of China. To resolve the abrupt shift in species composition between attached and floating macroalgal assemblages, field experiments were conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331de49af1c31694021b0db058052480
https://doi.org/10.1016/j.marpolbul.2019.01.056

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A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor models

Autor: Jing Wang, Grace Poon, Jeffrey Hanke, Kaiming Sun, Aparajitha Vaidyanathan, Sridhar Ramaswamy, Zhi Yi Zhang, Gillian Smith, Keith Mikule, Zebin Wang

Publikováno v: Oncotarget

Niraparib is an orally bioavailable and selective poly (ADP-ribose) polymerase (PARP)-1/-2 inhibitor approved for maintenance treatment of both BRCA mutant (mut) and BRCA wildtype (wt) adult patients with recurrent epithelial ovarian, fallopian tube,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302b87ae8feb7ac7cfc9c993d36e6b3a
https://doi.org/10.18632/oncotarget.26354

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Abstract 2126: Therapeutic potential of CPI-0209

Autor: Barbara M. Bryant, Jing Wang, John P. McGrath, Patrick Trojer, Andrew R. Conery, Kaiming Sun, Feng Zhao, Patricia J. Keller, Rentian Wu, Jennifer A. Mertz

Publikováno v: Cancer Research. 81:2126-2126

Second-generation EZH2 inhibitor CPI-0209 has therapeutic potential for androgen receptor-dependent prostate cancer Rentian Wu, Feng Zhao, Patricia J. Keller, Jennifer A. Mertz, John P. McGrath, Barbara Bryant, Andrew R. Conery, Kaiming Sun, Jing Wan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc77f570204b76020157547af447ef50
https://doi.org/10.1158/1538-7445.am2021-2126

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Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers

Autor: Guang-Xin Xu, Mylissa Borek, Anna W. Ma, Jing Wang, Steven DellaRocca, Maria Samson, Troy Patterson, Kaiming Sun, David Tuck, Ruzanna Atoyan, Jaye L. Viner, Ali Fattaey

Publikováno v: Molecular Cancer Therapeutics. 16:285-299

Upregulation of MYC is a common driver event in human cancers, and some tumors depend on MYC to maintain transcriptional programs that promote cell growth and proliferation. Preclinical studies have suggested that individually targeting upstream regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38efec963ed8b4e3240d982b5006d6b
https://doi.org/10.1158/1535-7163.mct-16-0390

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