Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kaimao Liu"'
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Publikováno v:
Nature Genetics. 42:742-744
We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human gamma-globin/beta-globin expression ratios. These results suggest that KLF1 controls globin gene switching by directly ac
Autor:
Dewang Zhou1, Kaimao Liu1, Chiao-Wang Sun1, Pawlik, Kevin M.1, Townes, Tim M.1 ttownes@uab.edu
Publikováno v:
Nature Genetics. Sep2010, Vol. 42 Issue 9, p742-744. 3p. 2 Color Photographs.
Autor:
Chao Li, Hengbin Wang, Amanda Jones, Chia-Wei Chang, Matthew R. Mysliwiec, Chiao-Wang Sun, Li-Chen Wu, Kevin M. Pawlik, Youngsook Lee, Qian Dai, Hediye Erdjument-Bromage, Kaimao Liu, Heui-Yun Joo, Wei Yang, Paul Tempst, Zhuo Zhang, Tim M. Townes, Jinrong Min, Yahong Guo
Publikováno v:
Stem cells (Dayton, Ohio). 29(2)
Polycomb repressive complex two (PRC2) has been implicated in embryonic stem (ES) cell pluripotency; however, the mechanistic roles of this complex are unclear. It was assumed that ES cells contain PRC2 with the same subunit composition as that ident
Autor:
Kevin M. Pawlik, Trenton R. Schoeb, Chia-Wei Chang, Chao Li, Yi-Shin Lai, Chiao-Wang Sun, Kaimao Liu, Tim M. Townes
Publikováno v:
Stem cells (Dayton, Ohio). 27(5)
We report the derivation of induced pluripotent stem (iPS) cells from adult skin fibroblasts using a single, polycistronic lentiviral vector encoding the reprogramming factors Oct4, Sox2, and Klf4. Porcine teschovirus-1 2A sequences that trigger ribo
Publikováno v:
Planta. 226(4)
Rice (Oryza sativa L.) plant is sensitive to chilling, particularly at early stages of seedling development. Here a novel cold-inducible gene, designated OsCOIN (Oryza sativa cold-inducible), was isolated and characterized. Results showed that OsCOIN
Autor:
Chia-Wei Chang, Yi-Shin Lai, Pawlik, Kevin M., Kaimao Liu, Chiao-Wang Sun, Chao Li, Schoeb, Trenton R., Townes, Tim M.
Publikováno v:
Stem Cells; May2009, Vol. 27 Issue 5, p1042-1049, 8p, 2 Color Photographs, 3 Diagrams, 1 Chart
Publikováno v:
Planta: An International Journal of Plant Biology; Jul2007, Vol. 226 Issue 4, p1007-1016, 10p, 1 Black and White Photograph, 2 Diagrams, 4 Graphs