Zobrazeno 1 - 10
of 468
pro vyhledávání: '"Kailin Xu"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Given its nearly ubiquitous expression on plasma cells and limited expression on essential normal tissue, the G protein-coupled receptor class C group 5 member D (GPRC5D) presents a promising opportunity for utilization as an immunotherapy t
Externí odkaz:
https://doaj.org/article/b4b2d848e2a5405c903b6328a7211437
Autor:
Yuhan Ma, Hongyuan Zhou, Jiaoli Zhang, Qing Zhang, Yujie Li, Ruiyang Xie, Bingpei Zhang, Ziyuan Shen, Ping Li, Aibin Liang, Keshu Zhou, Lu Han, Yongxian Hu, Kailin Xu, Wei Sang, Xiangmin Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundChimeric antigen receptor T-cell (CAR-T) therapy has offered new opportunities for patients with relapsed/refractory B-cell lymphoblastic leukemia (r/r B-ALL). However, cytokine release syndrome (CRS) and immune effector cell–associated n
Externí odkaz:
https://doaj.org/article/dc38e97ee33a4778844cb1f8c26c8343
Autor:
Ming Shi, Jiaojiao Wang, Hongming Huang, Dan Liu, Hai Cheng, Xu Wang, Wei Chen, Zhiling Yan, Wei Sang, Kunming Qi, Depeng Li, Feng Zhu, Zhenyu Li, Jianlin Qiao, Qingyun Wu, Lingyu Zeng, Xiaoming Fei, Weiying Gu, Yuqing Miao, Kailin Xu, Junnian Zheng, Jiang Cao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Despite the high therapeutic response achieved with B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapy in relapsed and refractory multiple myeloma (R/R MM), primary resistance and relapse exist with sing
Externí odkaz:
https://doaj.org/article/747a7911739249cd91c5dcffffc31488
Autor:
Seyram Yao Adzraku, Can Cao, Qi Zhou, Ke Yuan, Xiaowen Hao, Yue Li, Shengnan Yuan, Yujin Huang, Kailin Xu, Jianlin Qiao, Wen Ju, Lingyu Zeng
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-16 (2024)
Abstract Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow microenvironment to expand and refill the peripheral blood cell p
Externí odkaz:
https://doaj.org/article/24d1a43ab8b849df850fb1dc90a8c5ad
Autor:
Huimin Chen, Ruixue Ma, Qianqian Zhang, Fengyi Lu, Yuhan Ma, Jingxin Zhou, Jiang Cao, Kunming Qi, Zhiling Yan, Wei Sang, Feng Zhu, Haiying Sun, Depeng Li, Zhenyu Li, Hai Cheng, Kailin Xu, Wei Chen
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
ABSTRACTBackground: Peripheral T-cell lymphomas (PTCL) are an aggressive group of mature T-cell neoplasms, often associated with poor outcomes, in part, due to frequent relapsed/refractory disease. The objective of this study was to assess the progno
Externí odkaz:
https://doaj.org/article/ada56b4285714342bd2679a9915c325d
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background Despite continuous improvements in the new target and construction of chimeric antigen receptor (CAR)-T, relapse remains a significant challenge following CAR-T therapy. Tumor microenvironment (TME) strongly correlates with the efficacy of
Externí odkaz:
https://doaj.org/article/f5428730876f477d9afba5801c8ac8be
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Improving regeneration of damaged thymus is important for reconstituting T-cell immunity. Interleukin-22 (IL-22) was proved to improve thymus regeneration through recovering thymic epithelial cells (TECs). The IL-22 receptor IL-22RA1 is cruc
Externí odkaz:
https://doaj.org/article/a95303311a454101b9e5174df90b9bab
Autor:
Yangyang Ding, Xiang Gui, Xiang Chu, Yueyue Sun, Sixuan Zhang, Huan Tong, Wen Ju, Yue Li, Zengtian Sun, Mengdi Xu, Zhenyu Li, Robert K. Andrews, Elizabeth E. Gardiner, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1 in platelets are not known.
Externí odkaz:
https://doaj.org/article/c6a5b3d2352342c1b144fc7df9711183
Autor:
Ruonan Shao, Zijian Li, Honglei Xin, Suyu Jiang, Yilin Zhu, Jingan Liu, Rong Huang, Kailin Xu, Xiaofeng Shi
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which is often treated with induction chemotherapy regimens followed by consolidation or allogeneic hematopoietic stem cell transplantation (HSCT). However, so
Externí odkaz:
https://doaj.org/article/bffdb6b89bd448b1a282592fc98cb220
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract B cell maturation antigen (BCMA)-targeted immunotherapy has shown unprecedented results in the treatment of relapsed or refractory (R/R) multiple myeloma (MM). However, disease progression remains an issue attributed to variable BCMA express
Externí odkaz:
https://doaj.org/article/342cd68c1a4b49b094bd373bfe6c8182