Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kailey M. Slavik"'
Autor:
Yao Li, Kailey M. Slavik, Benjamin R. Morehouse, Carina C. de Oliveira Mann, Kepler Mears, Jingjing Liu, Dmitry Kashin, Frank Schwede, Philip J. Kranzusch
Publikováno v:
bioRxiv
SummarycGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2′3′-cGAMP that activates the protein STING and downstream immunity. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489eba22275e0630e8cfa11297397433
https://europepmc.org/articles/PMC9980059/
https://europepmc.org/articles/PMC9980059/
Autor:
Kenta Mosallanejad, Stephanie N. Kennedy, Kristin M. Bahleda, Kailey M. Slavik, Wen Zhou, Apurva A. Govande, Dustin C. Hancks, Philip J. Kranzusch, Jonathan C. Kagan
Publikováno v:
Science Immunology. 8
The mechanisms by which innate immune receptors mediate self-nonself discrimination are unclear. In this study, we found species-specific molecular determinants of self-DNA reactivity by cyclic guanosine monophosphate–adenosine monophosphate (GMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1591a49af567c168ab3cd335b9281163
https://doi.org/10.1126/sciimmunol.abp9765
https://doi.org/10.1126/sciimmunol.abp9765
