Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kailash N. Sawhney"'
Publikováno v:
International Journal of Peptide and Protein Research. 32:279-291
Synthetic routes have been developed for the preparation of functionalized amino acid derivatives in which the α-substituent at carbon 2 is either an aromatic or a heteroaromatic group. The α-substituent was introduced using an amidoalkylation reac
Publikováno v:
ChemInform. 22
Potent anticonvulsant activity has been reported for (R,S)-2-acetamido-N-benzyl-2-methylacetamide (2a). Select alpha-heteroatom substituted derivatives of 2a have been prepared (26 examples) in which the alpha-methyl group has been replaced by nitrog
Publikováno v:
ChemInform. 25
Publikováno v:
Journal of Pharmaceutical Sciences. 83:689-691
Recent studies have demonstrated that functionalized alpha,alpha-diamino acids (1) display excellent activity when evaluated in the maximal electroshock seizure (MES) test in mice. The synthesis and pharmacological evaluation of 14 select analogues w
Publikováno v:
Journal of medicinal chemistry. 36(22)
Earlier studies showed that (R,S)-alpha-acetamido-N-benzylacetamides (2) containing a five- and six-membered aromatic or heteroaromatic group appended at the C(alpha) site displayed outstanding activity in the maximal electroshock-induced seizure (ME
Autor:
Kailash N. Sawhney, Harold Kohn
Publikováno v:
Journal of Medicinal Chemistry. 32:248-252
A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparab
Autor:
Thomas L. Lemke, Kailash N. Sawhney
Publikováno v:
The Journal of Organic Chemistry. 48:4326-4329
La formation des bases de Schiff a lieu preferentiellement sur le carbonyle exocyclique des acyl-2 indanediones-1,3
Publikováno v:
Journal of Heterocyclic Chemistry. 24:1073-1076
Flash Vacuum Pyrolysis (FVP) of 3-t-Butylindeno[1,2-c]isoxazol-4-one (1) and 3-t-Butylspiro[2H-azirine-2,2′-(2H)indene]-1′,3′-dione (2) were carried out. Reaction of 1 from 300–400° afford 2 and 2-carbonyl-1,3-indandione 2-azine (3) as the m
Publikováno v:
Journal of Heterocyclic Chemistry. 19:363-368
Treatment of 2-pivaloyl-1,3-indandione (1) with hydroxylamine under acidic conditions, results in formation of 8-t-butylindeno[1,2-c]isoxazol-7-one (2) while treatment of the triketone with hydroxylamine at neutral or basic pH gave 6 which upon cycli
Autor:
Kailash N. Sawhney, Thomas L. Lemke
Publikováno v:
Journal of Heterocyclic Chemistry. 19:1335-1340
The reaction of the enaminoketones (2 or 5) of 2-acyl-1,3-indandiones with unsymmetrical hydrazines results in the regiospecific synthesis of 1,3- or 2,3-disubstituted indeno[1,2-c]pyrazol-4(1H)-ones (4 or 7). The synthesis of the enaminoketones (2 o