Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kaila L. Fadock"'
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 4955-4963 (2017)
Externí odkaz:
https://doaj.org/article/734c036f4fbb4fc3b1bcb25bae3193fd
Publikováno v:
Organic & Biomolecular Chemistry. 14:4409-4419
In this study, we describe the thermal and optical properties of the thrombin binding aptamer (TBA) that has been modified at syn-G-tetrad positions with fluorescent 8-heteroaryl-2'-deoxyguanosine derivatives consisting of pyrrolyl ((Pyr)dG), furyl (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9428b3e1975fb94db1740f6a5aeae0bb
https://doi.org/10.1039/c6ob00474a
https://doi.org/10.1039/c6ob00474a
Autor:
Richard A. Manderville, Darian J. M. Blanchard, Purshotam Sharma, Kaila L. Fadock, Prashant S. Deore, Michael Sproviero, Thomas Z. Cservenyi, Stacey D. Wetmore
Publikováno v:
Journal of Materials Chemistry C. 4:2915-2924
In this study, we outline the structural and photophysical properties of donor–acceptor (D–A) 8-aryl-2′-deoxyguanosine (8aryldG) probes within duplex and G-quadruplex (GQ) structures produced by the thrombin binding aptamer (TBA, 5′-GGTTG5G6T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b719a46ef8d4f51bf0d6d6253406fdc5
https://doi.org/10.1039/c5tc03354c
https://doi.org/10.1039/c5tc03354c
Autor:
Richard A. Manderville, Prashant S. Deore, Ahmed Y. Desoky, Abigail J Van Riesen, Shahin Sowlati-Hashjin, Stacey D. Wetmore, Kaila L. Fadock
Publikováno v:
Organicbiomolecular chemistry. 16(20)
Chemically modified aptamers have the opportunity to increase aptamer target binding affinity and provide structure-activity relationships to enhance our understanding of molecular target recognition by the aptamer fold. In the current study, 8-aryl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4200afbc5574919e1ef312ef182e1cc5
https://pubmed.ncbi.nlm.nih.gov/29745412
https://pubmed.ncbi.nlm.nih.gov/29745412
Publikováno v:
ACS Chemical Biology. 10:1311-1318
Emissive C8-aryl-2'-deoxyguanosines placed within G-tetrads of G-quadruplex structures are useful probes for distinguishing G-quadruplexes from duplex structures using fluorescence spectroscopy. Here, we report the positional impact of C8-furyl-dG ((
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92614fd43e464180a91c03d990ba8bb
https://doi.org/10.1021/cb5009926
https://doi.org/10.1021/cb5009926
Electronic tuning of fluorescent 8-aryl-guanine probes for monitoring DNA duplex–quadruplex exchange
Autor:
Michael Sproviero, Aaron A. Witham, Purshotam Sharma, Kaila L. Fadock, Stacey D. Wetmore, Richard A. Manderville
Publikováno v:
Chem. Sci.. 5:788-796
In DNA-based diagnostics, duplex–quadruplex exchange is a common strategy for target detection using fluorescent probes that turn-on during the exchange process. Typical “label” detection platforms use emissive tags that are attached via linker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe3d3f30a457910139d75dc7967b94f8
https://doi.org/10.1039/c3sc52625a
https://doi.org/10.1039/c3sc52625a