Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Kaikobad Irani"'
Autor:
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance. Here, we show that deletion of endothelial Sirt1,
Externí odkaz:
https://doaj.org/article/72b47199e1ba4328a43cb9d21627ccbf
Autor:
Jun Sun, M. Nedim Ince, Clara Abraham, Terrence Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney Newberry, Jonathan U. Peled, Israel Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao-Di Tan, Eric Tkaczyk, Jason Wertheim, Zheng Jenny Zhang
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTThe present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population expe
Externí odkaz:
https://doaj.org/article/35f57b6f47564d71a10ebcf40edbc4b6
Autor:
Seonhee Kim, Ikjun Lee, Shuyu Piao, Harsha Nagar, Su-jeong Choi, Young-Rae Kim, Kaikobad Irani, Byeong Hwa Jeon, Cuk-Seong Kim
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
miR204 is found to inhibit cpt1a in mouse hepatocytes, which could play a role in promoting non-alcoholic fatty liver disease.
Externí odkaz:
https://doaj.org/article/1b8771ab0e83418684aa0f195bf0d48e
Autor:
Jin‐Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long‐Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao‐Fu Dai
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). The metabolic derangement and underlying mechanisms of cardio‐encephalomyopathy in LS remains incompletely un
Externí odkaz:
https://doaj.org/article/9fc05873d4fb4a8a92652c0c9b8bc8e0
Autor:
Ravinder Reddy Gaddam, Young‐Rae Kim, Julia S. Jacobs, Jin‐Young Yoon, Qiuxia Li, Angela Cai, Hamsitha Shankaiahgari, Barry London, Kaikobad Irani, Ajit Vikram
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Background MicroRNAs regulate cardiac hypertrophy development, which precedes and predicts the risk of heart failure. microRNA‐204‐5p (miR‐204) is well expressed in cardiomyocytes, but its role in developing cardiac hypertrophy and cardiac dysf
Externí odkaz:
https://doaj.org/article/c8bea0cb37fd464bbb84ca559afe785c
Autor:
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-Jeong Choi, Byeong Hwa Jeon, Sang-Ha Oh, Kaikobad Irani, Cuk-Seong Kim
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1645 (2021)
Elevated plasma homocysteine levels can induce vascular endothelial dysfunction; however, the mechanisms regulating homocysteine metabolism in impaired endothelial cells are currently unclear. In this study, we deleted the essential mitoribosomal gen
Externí odkaz:
https://doaj.org/article/b96589ec9a694c9880c8d88e7f70f8a6
Autor:
Ajit Vikram, Young-Rae Kim, Santosh Kumar, Qiuxia Li, Modar Kassan, Julia S. Jacobs, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Commensal bacteria, the vast majority of which reside in the gut, are involved in development of many diseases, including atherosclerotic vascular disease. Here the authors show that these bacteria remotely increase expression of vascular microRNA-20
Externí odkaz:
https://doaj.org/article/c78103dbf37e4cb9a31d886ce4bad07c
Autor:
Shuyu Piao, Jun Wan Lee, Harsha Nagar, Saet-Byel Jung, Sujeong Choi, Seonhee Kim, Ikjun Lee, Sung-Min Kim, Nara Shin, Yu Ran Lee, Sang Do Lee, Jin Bong Park, Kaikobad Irani, Minho Won, Gang Min Hur, Byeong Hwa Jeon, Dong Woon Kim, Cuk-Seong Kim
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192693 (2018)
CR6 interacting factor 1 (CRIF1) deficiency impairs mitochondrial oxidative phosphorylation complexes, contributing to increased mitochondrial and cellular reactive oxygen species (ROS) production. CRIF1 downregulation has also been revealed to decre
Externí odkaz:
https://doaj.org/article/866a0c21e02342b19c472e10cfd46719
Autor:
Shubha Murthy, Olha M Koval, Juan M Ramiro Diaz, Santosh Kumar, Daniel Nuno, Jason A Scott, Chantal Allamargot, Linda J Zhu, Kim Broadhurst, Velarchana Santhana, William J Kutschke, Kaikobad Irani, Kathryn G Lamping, Isabella M Grumbach
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186311 (2017)
The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase important in transducing intracellular Ca2+ signals. While in vitro data regarding the role of CaMKII in the regulation of endothelial nitric oxide
Externí odkaz:
https://doaj.org/article/f354a460347249199e1fb8733db21214
Autor:
Harsha Nagar, Saet-byel Jung, Sun Kwan Kwon, Jung-Bum Park, Minho Shong, Hee-Jung Song, Byeong Hwa Jeon, Kaikobad Irani, Cuk-Seong Kim
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98670 (2014)
Mitochondrial dysfunction has been implicated in the pathophysiology of various cardiovascular diseases. CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunctio
Externí odkaz:
https://doaj.org/article/717730ee66f7401891b6d924003fbfbb