Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kaikai, Yi"'
Autor:
Xiaoteng Cui, Jixing Zhao, Guanzhang Li, Chao Yang, Shixue Yang, Qi Zhan, Junhu Zhou, Yunfei Wang, Menglin Xiao, Biao Hong, Kaikai Yi, Fei Tong, Yanli Tan, Hu Wang, Qixue Wang, Tao Jiang, Chuan Fang, Chunsheng Kang
Publikováno v:
Cancer Communications, Vol 43, Iss 12, Pp 1326-1353 (2023)
Abstract Background Metabolism reprogramming plays a vital role in glioblastoma (GBM) progression and recurrence by producing enough energy for highly proliferating tumor cells. In addition, metabolic reprogramming is crucial for tumor growth and imm
Externí odkaz:
https://doaj.org/article/00cb3e09a93e47169bf92b48fab6f99a
Autor:
Can Xu, Jixing Zhao, Jia Song, Menglin Xiao, Xiaoteng Cui, Lei Xin, Jianglong Xu, Yuhao Zhang, Kaikai Yi, Biao Hong, Fei Tong, Shaohui Tian, Yanli Tan, Chunsheng Kang, Chuan Fang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma (GBM) is the most common and lethal type of primary malignant central nervous system (CNS) tumor with an extremely poor prognosis, and the mesenchymal subtype of GBM has the worst prognosis. Here, we found that lncRNA PRADX was overexpre
Externí odkaz:
https://doaj.org/article/63cd2b606ac946ee98f831c0608f7984
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression
Autor:
Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang, Liang Zeng
Publikováno v:
Clinical and Translational Medicine, Vol 9, Iss 1, Pp 1-15 (2020)
Abstract Background The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone acetylation is importa
Externí odkaz:
https://doaj.org/article/6cc6edefc01140a9910ff5fb873dd0ea
Autor:
Kaikai Yi, Xiaoteng Cui, Xing Liu, Yunfei Wang, Jixing Zhao, Shixue Yang, Can Xu, Eryan Yang, Menglin Xiao, Biao Hong, Chuan Fang, Chunsheng Kang, Yanli Tan, Qixue Wang
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundImmunotherapy, especially checkpoint inhibitors targeting PD-1 or PD-L1, has revolutionized cancer therapy. However, PD-1/PD-L1 inhibitors have not been investigated thoroughly in glioblastoma (GBM). Studies have shown that polymerase 1 and
Externí odkaz:
https://doaj.org/article/ebed4cd34aec4e69be2629d5b7d77ccd
Autor:
Yunfei Wang, Kaikai Yi, Xing Liu, Yanli Tan, Weili Jin, Yansheng Li, Junhu Zhou, Hongjun Wang, Chunsheng Kang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundCheckpoint blockade therapies targeting programmed death ligand 1 (PD-L1) and its receptor programmed cell death 1 promote T cell-mediated immune surveillance against tumors and have been associated with significant clinical benefit in canc
Externí odkaz:
https://doaj.org/article/6e72c5e777a348118a3ce1ca60c55667
Autor:
Ying Cai, Eryan Yang, Xiuhua Yao, Xuebin Zhang, Qixue Wang, Yunfei Wang, Ji Liu, Weijia Fan, Kaikai Yi, Chunsheng Kang, Jialing Wu
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101792- (2021)
Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator (tPA) is the most important thrombolytic drug in the clinical tre
Externí odkaz:
https://doaj.org/article/47a765ea47ab45a7b8feffaeef279144
Autor:
Qixue Wang, Xing Liu, Junhu Zhou, Chao Yang, Guangxiu Wang, Yanli Tan, Ye Wu, Sijing Zhang, Kaikai Yi, Chunsheng Kang
Publikováno v:
Advanced Science, Vol 6, Iss 20, Pp n/a-n/a (2019)
Abstract RNA is rarely used as a therapeutic target due to its flexible structure and instability. CRISPR‐Cas13a is a powerful tool for RNA knockdown, and the potential application of CRISPR‐Cas13a in cancer cells should be further studied. In th
Externí odkaz:
https://doaj.org/article/e70d4906b2e1430b8abcd0d1c3713eb7
Autor:
Chao, Yang, Ye, Wu, Lin, Wang, Sidi, Li, Junhu, Zhou, Yanli, Tan, Jia, Song, Huike, Xing, Kaikai, Yi, Qi, Zhan, Jin, Zhao, Qixue, Wang, Xubo, Yuan, Chunsheng, Kang
Publikováno v:
Journal of Controlled Release. 345:537-548
Exosomes are small extracellular vehicles which could transport genetic materials and proteins between cells. Although there are reports about exosomes crossing the blood-brain barrier (BBB), the underlying mechanisms still need further study. We fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2c5f2af55ec8631709b704ff58e38c
https://doi.org/10.1016/j.jconrel.2022.03.038
https://doi.org/10.1016/j.jconrel.2022.03.038
Autor:
Qi Zhan, Kaikai Yi, Xiaoteng Cui, Xueping Li, Shixue Yang, Qixue Wang, Chuan Fang, Yanli Tan, Lijie Li, Can Xu, Xubo Yuan, Chunsheng Kang
Publikováno v:
Neuro Oncol
Background Targeting glioblastoma (GBM) energy metabolism through multiple metabolic pathways has emerged as an effective therapeutic approach. Dual inhibition of phospholipid and mitochondrial metabolism with cytoplasmic phospholipase A2 (cPLA2) kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b480cacb442d8d87ed4cfebba25c819
https://doi.org/10.1093/neuonc/noac071
https://doi.org/10.1093/neuonc/noac071
Autor:
Shixue, Yang, Jixing, Zhao, Xiaoteng, Cui, Qi, Zhan, Kaikai, Yi, Qixue, Wang, Menglin, Xiao, Yanli, Tan, Biao, Hong, Chuan, Fang, Chunsheng, Kang
Publikováno v:
Theranostics. 12:7032-7050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc9df18d44aa5c9d5f51e14c839fb92
https://doi.org/10.7150/thno.74197
https://doi.org/10.7150/thno.74197