An engineered Cas12i nuclease that is an efficient genome editing tool in animals and plants

Autor: Zhiqiang Duan, Yafeng Liang, Jialei Sun, Hongjin Zheng, Tong Lin, Pengyu Luo, Mengge Wang, Ruiheng Liu, Ying Chen, Shuhua Guo, Nannan Jia, Hongtao Xie, Meili Zhou, Minghui Xia, Kaijun Zhao, Shuhui Wang, Na Liu, Yongling Jia, Wei Si, Qitong Chen, Yechun Hong, Ruilin Tian, Jian-Kang Zhu

Publikováno v: The Innovation, Vol 5, Iss 2, Pp 100564- (2024)

Summary: The type V-I CRISPR-Cas system is becoming increasingly more attractive for genome editing. However, natural nucleases of this system often exhibit low efficiency, limiting their application. Here, we used structure-guided rational design an

Externí odkaz: https://doaj.org/article/073f0f0a881f4624ac8c5343f77182b5

Overview of the recent experimental research on the J-TEXT tokamak

Autor: Yonghua Ding, Nengchao Wang, Zhongyong Chen, Donghui Xia, Zhoujun Yang, Zhipeng Chen, Wei Zheng, Wei Yan, Da Li, Song Zhou, Xin Xu, Xiaoyi Zhang, Feiyue Mao, Jiangang Fang, Zhengkang Ren, Xixuan Chen, Junli Zhang, Xiaobo Zhang, Ying He, Qi Zhang, You Li, Wei Bai, Lingke Mou, Feng Li, Ting Long, Rui Ke, Li Gao, Peng Shi, Chengshuo Shen, Jiaxing Liu, Weixin Guo, Lu Wang, Hanhui Li, Zhonghe Jiang, Xiaoqing Zhang, Jianchao Li, Bo Rao, Zhifeng Cheng, Ping Zhu, Minghai Liu, Tao Xu, Shaoxiang Ma, Yong Yang, Chuan Li, Zhijiang Wang, Ming Zhang, Kexun Yu, Xiwei Hu, Y. Liang, Q. Yu, K. W. Gentle, Yuan Pan, the J-TEXT Team, Kenneth William Gentle, Qingquan Yu, Yunfeng Liang, Wei Jiang, Lin Yi, Ya Zhang, Qiming Hu, Mingxiang Huang, Haolong Li, Zhuo Huang, Jie Huang, Weijun Wang, Mei He, Qing Zhao, Jiayu Xu, Gangyi Zhou, Weigang Ba, Cheng Yang, Junjie Yao, Chuliang Wang, Bo He, Yongzhen Hu, Mingyang Deng, Jingwei Fu, Meiling Liang, Yehong Guan, Hongyan Wu, Ge Zhuang, Weixing Ding, Tao Lan, Shiyong Zeng, Malik Sadam Hussain, Zhifang Lin, Hai Liu, Youwen Sun, Long Zeng, Shaocheng Liu, Liang Liao, Wulyu Zhong, Zhongbing Shi, Min Jiang, Yunbo Dong, Min Xu, Aike Wang, Xiaolong Zhang, Linzi Liu, Ruihai Tong, Jun Cheng, Lin Nie, Hui Li, Jianqiang Xu, Zengchen Yang, Jie Wen, Anshu Liang, Yipo Zhang, Yifan Wu, Chengyuan Chen, Kaijun Zhao, Yuejiang Shi, He Huang, Max Austin, Sanggon Lee, Jr Neville C. Luhmann, Calvin W. Domier, Yilun Zhu, David L. Brower, Jie Chen, K. Ida, Y. Takemura, Y. Suzuki, K. Nagasaki, P. Drews, A. Knieps, Xiang Han, A. Krämer-Flecken, M. Henkel, Jiyang He, Yinan Zhou, Ruo Jia, Yue Peng, Pengyu Wang, Jiawei Li, Jie Yang, Conghui Lu, Yiwei Lu, Rumeng Wang, Hongqi Zhang, Yingqin Zeng, Guodong Zhang, Fangyuan Ma, Abba Alhaji Bala, Dingchen Li, Jiankun Hua, Xinkun Ai, Qinlin Tao, Yu Zhong, Yangbo Li, Xiangrui He, Sui Wan, Shanni Huang, Yiming Ma, Zitong Qu, Shimin Yu, Zhangsheng Huang, Chi Lei, Qinghu Yang, Fengming Xue, Chuanxu Zhao, Junhui Yang, Zili Chen, Jingmin Yang, Shengyang Xiao, Shiwei Xue, Wentao Geng, Jian Zhang, Xiong Tao, Zhigang Hao, Qiong Li, Jinyu Xiong, Huakun Cai, Mingzhu Zhang, Yaping Zhang, Yangming Zhao, Qiancheng Zhao, Shaodong Jiao, Dongliang Han, Shiyi Peng, Jiaolong Dong, Qinglong Yang, Fan Gu, Zhaosu Wang, Hao Wang, Shu Yang, Yang Zhao, Wang Lin, Guoyao Fan, Kehong Dong, Xiehang Ren, Ce Deng, Feng Han, Jing Liu, Qiqi Wu, Fei Xie, Yujie Zhong, Zinan Wei, Wanjun Qing, Chu Han, Hui Ye, Yingzhou Jiang, Chengyu Yang, Shuhao Li, Jianjun Yuan, Haojie Chen, Xiaobo Liu, Wentong Shang, Shengyuan Guan, Chouyao Tang, Sheng Li, Jiamao Gao, Wenting Weng, Shouqi Xiong, Yuan Gao, Zhichao Zhang, Boliang Zhu, Fuyou He, Feiyang Wu, Xianqian Zha, Tong Guo, Xiaohan Xie, Ruiyang Xu, Weikang Zhang, Zixiao Jiao, Chupin Fu, Chengzhi Guo, Sifen He, Yixing Jiang, Xianghao Kong, Cunkai Li, Zhen Li, Renzhe Liu, Ye Tian, Wenshan Wang, Yuhan Wang, Zutao Wang, Dengfeng Xu, Wendi Yang, Bangyou Zhu, Guangding Zhu, Xiating Mou, Xianlong Liu, Ziyang Jin, Jiaming Wang, Xinyu Cao, Cheng Han, Yanqiu Chen, Fanxi Liu, Haiqing Wang, Wei Xie, Wen Wang, Yutong Yang, Shaoyu Wang, An Mao, Peilong Zhang, Yanhao Zhao, Hengbun Ma, Zhiheng Li, Keze Li, Qiang Luo, Yuting Huang, Menghan Xiao, Yifei Huang, Guinan Zou, Yajun Wang, Dunrui Zhang, Zhi Zhang, Chaoxiang Guo, Bo Hu, Dengkuo Zhang, Junang Zhang, Jinlong Guo, Nan Wang, Qixiong Fu, Yisong Zhang, Jiong Guo, Yinlong Yu, Weijie Lin, Liye Wang, Jingtao Li, Zhangrong Hou, Xiaopeng Yi, Yi Zhang, Runyu Luo, Zijian Xuan, Xiping Jiang, Zisen Nie, Zhiyu Meng, Ziying Jiang, Xinyu Fang, Yuxuan Huang, Ning Peng, Xinyi Jin, Yujun Zhang, Zhongkai Li, Yuchen Zhang, Weimin Fu, Zijuan Dong, Yuhuan Liu, Anqi Hu, Zekai Guo, Weijie Ye, Zhenchang Du, Xun Zhou, Zhiyu Tang, Yan Guo, Zhiwen Yang, Xinchen Yao, Zezhi Yu, Boyu Zhao, Ruomu Wang, Yuwei Sun, Haocheng Wang, Tianyu Zheng, Chaofan Lu, Tianjing Wang, Zhuolong Li, Xiangyu Fu, Yulong Deng, Haojun Yu, Yuan Sheng, Yuanji Sun, Zi’an Mao, Lei Yu, Shaohua Ye, Wenjie Zhang, Qihang Jiang, Yushen Zhou, Jianfeng Zhu, Kexu Liu, Jinqiang Mao, Yunxiao Han, Zhihao Mai, Huchuan Zou, Jianliang Zheng, Zhiqiang Liu

Publikováno v: Nuclear Fusion, Vol 64, Iss 11, p 112005 (2024)

The J-TEXT capability is enhanced compared to two years ago with several upgrades of its diagnostics and the increase of electron cyclotron resonance heating (ECRH) power to 1 MW. With the application of electron cyclotron wave (ECW), the ECW assiste

Externí odkaz: https://doaj.org/article/18885b540574493da21f4cd8994201d3

Retreatment with a flow diverter for recurrent blood blister-like aneurysms after embolization: A single-center case series

Autor: Yazhou Yan, Shijie Zhu, Hao Yao, Yina Wu, Zhiwen Lu, Yibin Fang, Kaijun Zhao, Qinghai Huang

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

Background and purposeTreatment of blood blister-like aneurysms (BBAs) has been a significant challenge mainly due to their high recurrence rate even after stent-assisted coiling (SAC) embolization. This study aims to evaluate the safety and efficacy

Externí odkaz: https://doaj.org/article/4dd5f3e94a7b470da53ea576adc599b2

DNA Damage Response Evaluation Provides Novel Insights for Personalized Immunotherapy in Glioma

Autor: Mu Chen, Bingsong Huang, Lei Zhu, Qi Wang, Ying Pang, Meng Cheng, Hao Lian, Min Liu, Kaijun Zhao, Siyi Xu, Jing Zhang, Chunlong Zhong

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundDNA damage response (DDR) proficiency is the principal mechanism of temozolomide (TMZ) resistance in glioma. Accumulating evidence has also suggested the determining role of DDR in anticancer immunity. We propose that a comprehensive invest

Externí odkaz: https://doaj.org/article/2ce6ee18b6f74714aef749e6c4e25add

WATER-SOAKED SPOT1 Controls Chloroplast Development and Leaf Senescence via Regulating Reactive Oxygen Species Homeostasis in Rice

Autor: Jiangmin Xu, Zhiyuan Ji, Chunlian Wang, Feifei Xu, Fujun Wang, Yuhan Zheng, Yongchao Tang, Zheng Wei, Tianyong Zhao, Kaijun Zhao

Publikováno v: Frontiers in Plant Science, Vol 13 (2022)

Transmembrane kinases (TMKs) play important roles in plant growth and signaling cascades of phytohormones. However, its function in the regulation of early leaf senescence (ELS) of plants remains unknown. Here, we report the molecular cloning and fun

Externí odkaz: https://doaj.org/article/710daabd5d2940ecbb981ca49d3a482e