Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kaijing Zhao"'
Autor:
Ziming Li, Zhengbo Song, Wei Hong, Nong Yang, Yongsheng Wang, Hong Jian, Zibin Liang, Sheng Hu, Min Peng, Yan Yu, Yan Wang, Zicong Jiao, Kaijing Zhao, Ke Song, You Li, Wei Shi, Shun Lu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer (NSCLC). Here, we report re
Externí odkaz:
https://doaj.org/article/fe0a098c71754fae979d397f0443b2af
Autor:
Miao Zhang, Zhiheng Yu, Xueting Yao, Zihan Lei, Kaijing Zhao, Wenqian Wang, Xue Zhang, Xijing Chen, Dongyang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib cl
Externí odkaz:
https://doaj.org/article/be6fa8d0ddde4b4daa35e428b0069e02
Autor:
Yang Chen, Kaijing Zhao, Fei Liu, Qiushi Xie, Zeyu Zhong, Mingxing Miao, Xiaodong Liu, Li Liu
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Deoxypodophyllotoxin (DPT) is a potential anti-tumor candidate prior to its clinical phase. The aim of the study was to develop a physiologically-based pharmacokinetic (PBPK) model consisting of 13 tissue compartments to predict DPT disposition in mo
Externí odkaz:
https://doaj.org/article/0b5141a6bb994713a365a00c0a9a3d4d
Publikováno v:
Frontiers in Humanities and Social Sciences. 2:91-94
In order to achieve the goals of "carbon peaking" and "carbon neutrality", green finance and low-carbon economy are two important tools and approaches, so it is particularly important to evaluate the effect of green finance on low-carbon development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b38cf42448a0d1dd977bc2c07b44cf
https://doi.org/10.54691/fhss.v2i8.1662
https://doi.org/10.54691/fhss.v2i8.1662
Autor:
Chen Ou, Kaijing Zhao
Publikováno v:
Functions of Language. 29:226-231
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2dd8f7d5363cf50e1ab0a070909982
https://doi.org/10.1075/fol.00034.ou
https://doi.org/10.1075/fol.00034.ou
Autor:
Shun Lu, Hong Jian, Wei Hong, Zhengbo Song, Nong Yang, Sheng Hu, Zibin Liang, Yongsheng Wang, Yan Wang, Min Peng, Yan Yu, You Li, Jiapeng Shuang, Kaijing Zhao
Publikováno v:
Cancer Research. 83:CT204-CT204
Introduction: HER2-mutant NSCLC is associated with poor prognosis. SHR-A1811 is a novel antibody-drug conjugate (ADC) consisting of a humanized HER2-directed monoclonal antibody, cleavable tetrapeptide-based linker, and DNA topoisomerase I inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe13ad8b1be5307723bcd372d0e3bba8
https://doi.org/10.1158/1538-7445.am2023-ct204
https://doi.org/10.1158/1538-7445.am2023-ct204
Autor:
Herui Yao, Min Yan, Zhongsheng Tong, Xinhong Wu, Min-Hee Ryu, Jee Hyun Kim, John Park, Yahua Zhong, Weiqing Han, Caigang Liu, Mark Voskoboynik, Qun Qin, Jian Zhang, Minal Barve, Ana Acuna-Villaorduna, Vinod Ganju, Seock-Ah Im, Changsheng Ye, Yongmei Yin, Amitesh C. Roy, Li-Yuan Bai, Yung-Chang Lin, Chia-Jui Yen, Hui Li, Ki Young Chung, Shanzhi Gu, Jun Qian, Yuee Teng, Yiding Chen, Yu Shen, Kaijing Zhao, Shangyi Rong, Xiaoyu Zhu, Erwei Song
Publikováno v:
Cancer Research. 83:CT175-CT175
Background: SHR-A1811 is an ADC comprised of a humanized anti-HER2 monoclonal antibody (trastuzumab), a cleavable linker, and a DNA topoisomerase I inhibitor payload. Here we assessed SHR-A1811 in HER2-expressing/mutated unresectable, advanced, or me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d978a8e8b719394b4beb2d8f6bf34ce6
https://doi.org/10.1158/1538-7445.am2023-ct175
https://doi.org/10.1158/1538-7445.am2023-ct175
Autor:
Kaijing Zhao, Binbin Sun, Jia-xin Zhang, Xiao-ke Zheng, Peihua Liu, Ru-jun Xu, Li Liu, Zhongjian Wang, Ping Li, Weimin Kong, Liang Zhu, Yang Chen, Xiao-dong Liu
Publikováno v:
Acta Pharmacologica Sinica
Vonoprazan is characterized as having a long-lasting antisecretory effect on gastric acid. In this study we developed a physiologically based pharmacokinetic (PBPK)-pharmacodynamic (PD) model linking to stomach to simultaneously predict vonoprazan ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a46d4ea0bae23593a4539d0e016070e
https://doi.org/10.1038/s41401-019-0353-2
https://doi.org/10.1038/s41401-019-0353-2
Autor:
Nan Chen, Xiaodong Liu, Li Liu, Yang Chen, Ping Li, Hanyu Yang, Limin Liang, Donghao Geng, Zhongjian Wang, Jiong Xu, Kaijing Zhao, Xiangping Zhang
Publikováno v:
Drug Metabolism and Disposition. 47:1066-1079
Atorvastatin is a substrate of cytochrome P450 3a (CYP3a), organic anion-transporting polypeptides (OATPs), breast cancer-resistance protein (BCRP), and P-glycoprotein (P-gp). We aimed to develop a semiphysiologically based pharmacokinetic (semi-PBPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d88c0b72c98d35038c292008021e8a8
https://doi.org/10.1124/dmd.118.085902
https://doi.org/10.1124/dmd.118.085902
Publikováno v:
European Journal of Pharmaceutical Sciences. 134:194-204
Several reports demonstrated that rifampicin affected pharmacokinetics of victim drugs following oral more than intravenous administration. We aimed to establish a semi-physiologically based pharmacokinetic (semi-PBPK) model involving both enzyme and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3927df8876f6e1527d1657359fad32
https://doi.org/10.1016/j.ejps.2019.04.026
https://doi.org/10.1016/j.ejps.2019.04.026