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Akademický článek

Rational Enzyme Design: Computer Modeling and Site-directed Mutagenesis for the Modification of Catalytic Specificity in Organophosphorus Hydrolase

Autor: Kaihua Lai, Janet K. Grimsley, Barbara D. Kuhlmann, Leonardo Scapozza, Steven P. Harvey, Joseph J. DeFrank, Jan E. Kolakowski, James R. Wild

Publikováno v: CHIMIA, Vol 50, Iss 9 (1996)

Externí odkaz: https://doaj.org/article/960bba2fc5f04adf9d44dd3959d9f2de

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Modification of Near Active Site Residues in Organophosphorus Hydrolase Reduces Metal Stoichiometry and Alters Substrate Specificity

Autor: Barbara D. Disioudi, Kaihua Lai, James R. Wild, Janet K. Grimsley

Publikováno v: Biochemistry. 38:2866-2872

Organophosphorus hydrolase (OPH, EC 8.1.3.1) is a dimeric, bacterial enzyme that detoxifies many organophosphorus neurotoxins by hydrolyzing a variety of phosphonate bonds. The histidinyl residues at amino acid positions 254 and 257 are located near

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4698a4a79bda483254dde68360076590
https://doi.org/10.1021/bi9825302

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Enzymatic Hydrolysis of the Chemical Warfare Agent VX and its Neurotoxic Analogues by Organophosphorus Hydrolase

Autor: Linda L. Szafraniec, Jan E. Kolakowski, Kaihua Lai, William T. Beaudry, Joseph J. DeFrank, James R. Wild, Steven P. Harvey

Publikováno v: Biocatalysis and Biotransformation. 15:297-312

Organophosphorus hydrolase (OPH) is a bacterial enzyme that hydrolyzes a variety of organophosphorus (OP) neurotoxins, including many widely used pesticides and chemical warfare agents containing P-O, P-F, P-CN and P-S bonds. It has extremely high ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4be607be580f1ee1b860adca8ed81dc
https://doi.org/10.3109/10242429709003196

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Rational design of organophosphorus hydrolase for altered substrate specificities

Autor: Barbara D. Di Sioudi, Janet K. Grimsley, Charles E. Miller, Kaihua Lai, James R. Wild

Publikováno v: Chemico-biological interactions.

Organophosphorus hydrolase (OPH) is a bacterial enzyme that hydrolyzes a broad variety of OP neurotoxins, including chemical warfare agents and many widely used pesticides. OPH has extremely high hydrolytic efficiency with different phosphotriester a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7b29a5d7d2444307ba3a7279d86b5c
https://pubmed.ncbi.nlm.nih.gov/10421455

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Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells

Autor: Kaihua Lai, Nicholas E.S. Sibinga, Cam Patterson, Burak M. Arkonac, Edgar Haber, Mark A. Perrella, Jer-Chia Tsai, Mu-En Lee, Lauren C. Foster

Publikováno v: The Journal of biological chemistry. 273(8)

Although several cytokines and growth factors have been shown to regulate vascular endothelial growth factor (VEGF) production, little is known about how VEGF may regulate growth factors that have known mitogenic and chemotactic actions on mesenchyma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f407f67fc8e2f11747b3f552a0468c4
https://pubmed.ncbi.nlm.nih.gov/9468491

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Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine

Autor: Masao Yoshizumi, Hong Wang, Mark A. Perrella, Jer-Chia Tsai, Mu-En Lee, Kaihua Lai, Edgar Haber

Publikováno v: The Journal of biological chemistry. 272(40)

Although hyperhomocysteinemia has been recognized recently as a prevalent risk factor for myocardial infarction and stroke, the mechanisms by which it accelerates arteriosclerosis have not been elucidated, mostly because the biological effects of hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2fe072281d3bab320f68e01af91d8f
https://pubmed.ncbi.nlm.nih.gov/9312159

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Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation

Autor: Mu-En Lee, Hong Wang, Mukesh K. Jain, Wen Sen Lee, Edgar Haber, Kaihua Lai

Publikováno v: The Journal of clinical investigation. 98(7)

Smooth muscle cell proliferation and migration is important in arteriosclerosis. In this process, cytokines and growth factors are upregulated and bind to their respective receptors, which in turn stimulate mitogen-activated protein (MAP) kinases. MA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80be6c6feee915fcb287156099aeadb4
https://pubmed.ncbi.nlm.nih.gov/8833904

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Vascular endothelial growth factor induces heparin-binding epidermal growth factor-like growth factor in vascular endothelial cells

Autor: Burak M. Arkonac, Lauren C. Foster, Nicholas E.S. Sibinga, Cam Patterson, Kaihua Lai, Jer-Chia Tsai, Mu-En Lee, Mark A. Perrella, Edgar Haber

Publikováno v: Journal of Biological Chemistry. 273:9352

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec77a72c21717ef712468baff9f7188c
https://doi.org/10.1016/s0021-9258(18)49640-8

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