771 A phase 1 study to assess safety, efficacy, pharmacokinetics, and pharmacodynamics of intratumoral CLN-617 (IL2/IL12 fusion protein) combined with pembrolizumab in patients with advanced solid tumors

Autor: Evan Hall, Adi Diab, Sajeve Thomas, Randy Sweis, Anthony El-Khoueiry, Naveen K Mehta, Jennifer S Michaelson, Laura Liu, Reham Abdel-Wahab, Jeffrey A Jones, Kaida Wu, Benjamin S Maciejewski

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/3894269b8f7b430fa6dbb37f186f00ac

Supplementary Figures 1-2, Table 1 from A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Autor: Selina Chen-Kiang, Malcolm A.S. Moore, Scott Ely, Hearn Cho, Ruben Niesvizky, Rachel Gottschalk, Tracey Louie, Peter L. Toogood, Kaida Wu, Maurizio Di Liberto, Linda B. Baughn

Supplementary Figures 1-2, Table 1 from A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0182bafba70a0f9b3b564f23804f44bf
https://doi.org/10.1158/0008-5472.22364481.v1

Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX

Autor: Philippe Moreau, Nizar J. Bahlis, Jesús F. San-Miguel, Kihyun Kim, Kaida Wu, Shinsuke Iida, Gordon Cook, Hervé Avet-Loiseau, Nushmia Z. Khokhar, Ajai Chari, A. Kate Sasser, Andrew Belch, Naoki Takezako, Jonathan L. Kaufman, Lisa O'Rourke, H. Miles Prince, Christopher Chiu, Lotfi Benboubker, Marc Lalancette, Saad Z. Usmani, Jordan M. Schecter, P. Joy Ho, James Morton, Jin Seok Kim, Heather J. Sutherland, Darrell White, Tara Cochrane, Albert Oriol, Tineke Casneuf, Meletios A. Dimopoulos, Hila Magen, David Soong, Merav Leiba

Publikováno v: Haematologica
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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In the POLLUX study, daratumumab plus lenalidomide/dexamethasone significantly reduced risk of progression/death versus lenalidomide/dexamethasone alone in relapsed/refractory multiple myeloma. We provide one additional year of follow-up and include

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1d9f1ec1e0b3824ac7004150f04151
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5344

Depth of Response and MRD with Daratumumab Plus Lenalidomide and Dexamethasone (DRd) vs Lenalidomide and Dexamethasone (Rd) in RRMM: POLLUX

Autor: Jonathan L. Kaufman, Lofti Benboubker, Ajai Chari, Jesús F. San-Miguel, Marc Lalancette, Jin Seok Kim, Kihyun Kim, Saad Z. Usmani, H. Miles Prince, Kaida Wu, P. Joy Ho, Tara Cochrane, Naoki Takezako, Albert Oriol, Nizar J. Bahlis, Gordon Cook, Hila Magen, Shinsuke Iida, Tineke Casneuf, Meletios A. Dimopoulos, Andrew Belch, Heather J. Sutherland, James P. Morton, Darrell White, Merav Leiba

Publikováno v: Clinical Lymphoma Myeloma & Leukemia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea3525c718ab79b5e8a1b5c8c84ba3d
https://doi.org/10.1016/j.clml.2017.03.029

A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6

Autor: Malcolm A.S. Moore, Ruben Niesvizky, Maurizio Di Liberto, Peter L. Toogood, Kaida Wu, Hearn Cho, Selina Chen-Kiang, Tracey Louie, Rachel A. Gottschalk, Scott Ely, Linda B. Baughn

Publikováno v: Cancer Research. 66:7661-7667

Cell cycle deregulation is central to the initiation and fatality of multiple myeloma, the second most common hematopoietic cancer, although impaired apoptosis plays a critical role in the accumulation of myeloma cells in the bone marrow. The mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ffb45656d7e03714183cbc0d4092b4
https://doi.org/10.1158/0008-5472.can-06-1098