Výsledky vyhledávání - "Kai-Wen Feng"

Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease

Autor: Jie Liu, Lu Liu, Lei Zheng, Kai-Wen Feng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou

Publikováno v: European journal of medicinal chemistry. 238

Recently, the discovery of multifunctional molecules that target different factors in the treatment of dementia is a significant research area. Both PDE4 and AChE inhibitors display improvement in cognitive and memory function. In this study, twenty-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2657ae417a5710eef57bb3ec8d3de4
https://pubmed.ncbi.nlm.nih.gov/35689855

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Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

Autor: Chuang Xia, Jia-Peng He, Kai-Wen Feng, Lu Liu, Lei Zheng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou

Publikováno v: ACS chemical neuroscience. 13(3)

To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a0eb3a6e6f589078025155d136d470
https://pubmed.ncbi.nlm.nih.gov/35050567

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Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

Autor: XiaoYang Li, HuanXian Wu, Kai-Wen Feng, JiaHuan Xu, Shaoyu Wu, zhong-zhen zhou, Xiao-Fang Li

Publikováno v: Bioorganic & Medicinal Chemistry. 73:117007

Nineteen TH03 analogues were designed and synthesized as tubulin colchicine-binding site inhibitors with potent antiproliferative activities. Among these compounds, 3,5-dimethoxyphenylpyridines 8j bearing a 4-methoxybenzyl aniline side-chain displaye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e95c7971606dfcae059ae6596573d19
https://doi.org/10.1016/j.bmc.2022.117007

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Synthesis of 4-Oxoisoxazoline N-Oxides via Pd-Catalyzed Cyclization of Propargylic Alcohols with tert-Butyl Nitrite

Autor: Kai-Wen Feng, Pan-Feng Yuan, Ran Fang, Wen-Long Lei, Yong-Liang Ban, Qiang Liu

Publikováno v: Organic Letters. 21:3131-3135

A cyclization of propargylic alcohols with tert-butyl nitrite at room temperature in air was achieved using Pd(OAc)2 as catalyst. The first reported 4-oxoisoxazoline N-oxides could be directly accessed from a range of multisubstituted propargylic alc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b5e208ce5b2b6312d2592b7bc2afc2
https://doi.org/10.1021/acs.orglett.9b00811

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Meyer-Schuster-Type Rearrangement of Propargylic Alcohols into α-Selenoenals and -enones with Diselenides

Autor: Fei-Cen Ma, Long You, Kai-Wen Feng, Xiao-Ling Jin, Yong-Liang Ban, Qiang Liu

Publikováno v: The Journal of organic chemistry. 86(7)

We describe a mild and broadly applicable protocol for the preparation of a diverse array of multisubstituted α-selenoenals and -enones from readily accessible propargylic alcohols and diselenides. The transformation proceeds via the Selectfluor-pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89768a90021741859a3ec8d818697855
https://pubmed.ncbi.nlm.nih.gov/33709711

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[Spatiotemporal Differentiation and Degradation Analysis of Polybrominated Diphenyl Ethers in Sediments of Shanmei Reservoir and Its Inflowing River, Quanzhou, China]

Autor: Wen-Liang, Han, Yu, Liu, Kai-Wen, Feng

Publikováno v: Huan jing ke xue= Huanjing kexue. 41(10)

To investigate the spatiotemporal differentiation of polybrominated diphenyl ethers (PBDEs) in urban water-source reservoirs and degradation sources of BDE homologues and their contributions, we analyzed the contents, pollution degrees, spatial distr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b191a9c60ecb6209624c43f1cbae3745
https://pubmed.ncbi.nlm.nih.gov/33124384

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Eosin Y- and Copper-Catalyzed Dark Reaction To Construct Ene-γ-Lactams

Autor: Qiang Liu, Wen-Long Lei, Li-Zhu Wu, Tao Wang, Kai-Wen Feng

Publikováno v: Organic Letters. 20:7220-7224

Eosin Y, a common organo-photocatalyst in visible-light photoredox processes, was found to show excellent catalytic activities for thermal redox reactions under a catalytic amount of Cu(OAc)2. With this catalytic system, vinyl azides and ketene silyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997e76e84f1736c254c6bf4c5adbf4a8
https://doi.org/10.1021/acs.orglett.8b03147

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Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by In Situ Generated Copper Photocatalyst

Autor: Tao Wang, Li-Zhu Wu, Qiang Liu, Wen-Long Lei, Kai-Wen Feng

Publikováno v: ACS Catalysis. 7:7941-7945

Room-temperature synthesis of 4-alkyl/aryl-2-aminothiazoles from vinyl azides and ammonium thiocyanate was accomplished with the aid of copper salts and blue LED irradiation. Mechanism investigation indicates that in situ-formed Cu(NCS)2– plays dua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aafadc81296145cc8d4cab4cda1752ab
https://doi.org/10.1021/acscatal.7b02818

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