The neuroprotective steroid progesterone promotes mitochondrial uncoupling, reduces cytosolic calcium and augments stress resistance in yeast cells

Autor: Slaven Stekovic, Christoph Ruckenstuhl, Phillip Royer, Christof Winkler-Hermaden, Didac Carmona-Gutierrez, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo

Publikováno v: Microbial Cell, Vol 4, Iss 6, Pp 191-199 (2017)

The steroid hormone progesterone is not only a crucial sex hormone, but also serves as a neurosteroid, thus playing an important role in brain function. Epidemiological data suggest that progesterone improves the recovery of patients after traumatic

Externí odkaz: https://doaj.org/article/ca88f07167bb485787286ace4dc87e78

Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.

Autor: Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Alice G Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Mariño, Rafal Koziel, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo

Publikováno v: PLoS Genetics, Vol 10, Iss 5, p e1004347 (2014)

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single delet

Externí odkaz: https://doaj.org/article/2513812671d248ae85a0d77c88148d65

The neuroprotective steroid progesterone promotes mitochondrial uncoupling, reduces cytosolic calcium and augments stress resistance in yeast cells

Autor: Didac Carmona-Gutierrez, Guido Kroemer, Frank Madeo, Kai-Uwe Fröhlich, Christoph Ruckenstuhl, Christof Winkler-Hermaden, Philipp Royer, Slaven Stekovic

Publikováno v: Microbial Cell
Microbial Cell, Vol 4, Iss 6, Pp 191-199 (2017)

The steroid hormone progesterone is not only a crucial sex hormone, but also serves as a neurosteroid, thus playing an important role in brain function. Epidemiological data suggest that progesterone improves the recovery of patients after traumatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c44e5896fdf84627a757371c269c218
http://europepmc.org/articles/PMC5473691

Guidelines and recommendations on yeast cell death nomenclature

Autor: Cornelia Sommer-Ruck, Michel Mb Toledano, Guido Kroemer, María Segovia, Christa Meisinger, Jens Nielsen, Stéphane Picot, Campbell W. Gourlay, Antonio Jiménez-Ruiz, Raffael Schaffrath, Manuela Côrte-Real, Richard Y. Zhao, Didac Carmona-Gutierrez, Frank Madeo, Zhaojie J Zhang, Maria A. Bauer, F-Nora Vögtle, Andrés Aguilera, Ali Gargouri, Kathryn R. Ayscough, Nicolas Fasel, Paula Ludovico, Maria João Sousa, Patrick Rockenfeller, Stéphen Manon, Johannes M. Herrmann, Dina Petranovic, Vítor Costa, Lorenzo Galluzzi, Nicoletta Guaragnella, Benedikt Westermann, Marc Blondel, Christophe Cullin, Lynn La Megeney, William Wc Burhans, Michael Breitenbach, Peter Polčic, Jürgen J. Heinisch, Thomas Heger, Katrina Kf Cooper, Tiago Tf Outeiro, Birthe Fahrenkrog, Stephan J. Sigrist, Antonio Barrientos, Andreas Zimmermann, Michael Chang, Paola Goffrini, Michael Mt Greenwood, Amir Sharon, Bing Zhou, Shoshana Bar-Nun, Sabrina Büttner, Ian W. Dawes, Rena Balzan, Karin Thevissen, Duccio Cavalieri, Eva Herker, Joris Winderickx, Tobias Eisenberg, Nicanor Austriaco, Ted Powers, Tobias Pendl, Kai-Uwe Fröhlich, Vladimir I. Titorenko, Stefan Wölfl, Martin Mb Dickman, Sebastian J. Hofer, Thomas Nyström, Sergio Giannattasio, Cristina Mazzoni, Johan Jm Thevelein, Silke Wissing, Mick F. Tuite, Peter Belenky, Heinz Hd Osiewacz, Mark Rinnerthaler, Helmut Jungwirth, Christoph Ruckenstuhl, Fedor Ff Severin, Mark Ramsdale, Enzo Martegani, Chris M. Grant, Dimitrios P. Kontoyiannis, Jörn Dengjel, Hay-Oak Park, Ralf J. Braun, Katharina Kainz

Publikováno v: Microbial Cell
Microbial Cell, Shared Science Publishers OG, 2018, 5 (1), pp.4-31
Microbial Cell, Vol 5, Iss 1, Pp 4-31 (2018)
Carmona-Gutierrez, D, Bauer, M A, Zimmermann, A, Aguilera, A, Austriaco, N, Ayscough, K, Balzan, R, Bar-Nun, S, Barrientos, A, Belenky, P, Blondel, M, Braun, R J, Breitenbach, M, Burhans, W C, Büttner, S, Cavalieri, D, Chang, M, Cooper, K F, Côrte-Real, M, Costa, V, Cullin, C, Dawes, I, Dengjel, J, Dickman, M B, Eisenberg, T, Fahrenkrog, B, Fasel, N, Fröhlich, K U, Gargouri, A, Giannattasio, S, Goffrini, P, Gourlay, C W, Grant, C M, Greenwood, M T, Guaragnella, N, Heger, T, Heinisch, J, Herker, E, Herrmann, J M, Hofer, S, Jiménez-Ruiz, A, Jungwirth, H, Kainz, K, Kontoyiannis, D P, Ludovico, P, Manon, S, Martegani, E, Mazzoni, C, Megeney, L A, Meisinger, C, Nielsen, J, Nystrøm, T, Osiewacz, H D, Outeiro, T F, Park, H O, Pendl, T, Petranovic, D, Picot, S, Polčic, P, Powers, T, Ramsdale, M, Rinnerthaler, M, Rockenfeller, P, Ruckenstuhl, C, Schaffrath, R, Segovia, M, Severin, F F, Sharon, A, Sigrist, S J, Sommer-Ruck, C, Sousa, M J, Thevelein, J M, Thevissen, K, Titorenko, V, Toledano, M B, Tuite, M, Vögtle, F N, Westermann, B, Winderickx, J, Wissing, S, Wölfl, S, Zhang, Z J, Zhao, R Y, Zhou, B, Galluzzi, L, Kroemer, G & Madeo, F 2018, ' Guidelines and recommendations on yeast cell death nomenclature ', Microbial Cell Factories, vol. 5, no. 1, pp. 4-31 . https://doi.org/10.15698/mic2018.01.607
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Microbial Cell, 2018, 5 (1), pp.4-31. ⟨10.15698/mic2018.01.607⟩
Microbial Cell, Shared Science Publishers OG, 2018, 5 (1), pp.4-31. ⟨10.15698/mic2018.01.607⟩
Microbial cell 5 (2018): 4–31. doi:10.15698/mic2018.01.607
info:cnr-pdr/source/autori:Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andres; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; Bar-Nun, Shoshana; Barrientos, Antonio; Belenky, Peter; Blondel, Marc; Braun, Ralf J.; Breitenbach, Michael; Burhans, William C.; Buttner, Sabrina; Cavalieri, Duccio; Chang, Michael; Cooper, Katrina F.; Corte-Real, Manuela; Costa, Vitor; Cullin, Christophe; Dawes, Ian; Dengjel, Jorn; Dickman, Martin B.; Eisenberg, Tobias; Fahrenkrog, Birthe; Fasel, Nicolas; Frohlich, Kai-Uwe; Gargouri, Ali; Giannattasio, Sergio; Goffrini, Paola; Gourlay, Campbell W.; Grant, Chris M.; Greenwood, Michael T.; Guaragnella, Nicoletta; Heger, Thomas; Heinisch, Juergen; Herker, Eva; Herrmann, Johannes M.; Hofer, Sebastian; Jimenez-Ruiz, Antonio; Jungwirth, Helmut; Kainz, Katharina; Kontoyiannis, Dimitrios P.; Ludovico, Paula; Manon, Stephen; Martegani, Enzo; Mazzoni, Cristina; Megeney, Lynn A.; Meisinger, Chris; Nielsen, Jens; Nystrom, Thomas; Osiewacz, Heinz D.; Outeiro, Tiago F.; Park, Hay-Oak; Pendl, Tobias; Petranovic, Dina; Picot, Stephane; Polcic, Peter; Powers, Ted; Ramsdale, Mark; Rinnerthaler, Mark; Rockenfeller, Patrick; Ruckenstuhl, Christoph; Schaffrath, Raffael; Segovia, Maria; Severin, Fedor F.; Sharon, Amir; Sigrist, Stephan J.; Sommer-Ruck, Cornelia; Sousa, Maria Joao; Thevelein, Johan M.; Thevissen, Karin; Titorenko, Vladimir; Toledano, Michel B.; Tuite, Mick; Voegtle, F.-Nora; Westermann, Benedikt; Winderickx, Joris; Wissing, Silke; Woelfl, Stefan; Zhang, Zhaojie J.; Zhao, Richard Y.; Zhou, Bing; Galluzzi, Lorenzo; Kroemer, Guido; Madeo, Frank/titolo:Guidelines and recommendations on yeast cell death nomenclature/doi:10.15698%2Fmic2018.01.607/rivista:Microbial cell/anno:2018/pagina_da:4/pagina_a:31/intervallo_pagine:4–31/volume:5
Microbial Cell, vol. 5, no. 1, pp. 4-31
Microbial cell, 5 (1
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d417ec631caa857ce4cd6845d0bc58
http://www.scopus.com/inward/record.url?scp=85047020782&partnerID=8YFLogxK

Ceramide triggers metacaspase-independent mitochondrial cell death in yeast

Autor: Sabrina Büttner, Guido Kroemer, Frank Madeo, Ralf J. Braun, Didac Carmona-Gutierrez, Angela Reisenbichler, Kai-Uwe Fröhlich, Christoph Ruckenstuhl, Petra Heimbucher, Tobias Eisenberg, Patrick Rockenfeller, Maria A. Bauer

Publikováno v: Cell Cycle. 10:3973-3978

The activation of ceramide-generating enzymes, the blockade of ceramide degradation, or the addition of ceramide analogues can trigger apoptosis or necrosis in human cancer cells. Moreover, endogenous ceramide plays a decisive role in the killing of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93df12c7632debeb30d870e2b942bca7
https://doi.org/10.4161/cc.10.22.18212