Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kai-Michael Toellner"'
Autor:
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor L. J. Tybulewicz, Antal Rot, Anja E. Hauser, Menna R. Clatworthy, Kai-Michael Toellner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to pot
Externí odkaz:
https://doaj.org/article/1cb0d96134a549388a75aab8fcbbbcaf
Autor:
Siân E. Jossi, Melissa Arcuri, Areej Alshayea, Ruby R. Persaud, Edith Marcial-Juárez, Elena Palmieri, Roberta Di Benedetto, Marisol Pérez-Toledo, Jamie Pillaye, Will M. Channell, Anna E. Schager, Rachel E. Lamerton, Charlotte N. Cook, Margaret Goodall, Takeshi Haneda, Andreas J. Bäumler, Lucy H. Jackson-Jones, Kai-Michael Toellner, Calman A. MacLennan, Ian R. Henderson, Francesca Micoli, Adam F. Cunningham
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionVaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better protection i
Externí odkaz:
https://doaj.org/article/8d8d1d6c683c43d999c25609b7e2e59d
Autor:
Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102038- (2021)
Summary: It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1Cre/wtPtpn6fl/fl mice where SHP-1, a negative regulator of BCR signaling, is delet
Externí odkaz:
https://doaj.org/article/2683f28e2d1c4ba08fa4c42ead60d9c9
Autor:
Emma Jennings, Thomas A.E. Elliot, Natasha Thawait, Shivani Kanabar, Juan Carlos Yam-Puc, Masahiro Ono, Kai-Michael Toellner, David C. Wraith, Graham Anderson, David Bending
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108328- (2020)
Summary: Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities to TCR signal strength and duration remains unclear. U
Externí odkaz:
https://doaj.org/article/2a8552a3db8b42ca9b7d30801fa9df36
Autor:
Anna E. Schager, C. Coral Dominguez-Medina, Francesca Necchi, Francesca Micoli, Yun Shan Goh, Margaret Goodall, Adriana Flores-Langarica, Saeeda Bobat, Charlotte N. L. Cook, Melissa Arcuri, Arianna Marini, Lloyd D. W. King, Faye C. Morris, Graham Anderson, Kai-Michael Toellner, Ian R. Henderson, Constantino López-Macías, Calman A. MacLennan, Adam F. Cunningham
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease. Immunization with naturally shed outer membrane vesicles from Gram
Externí odkaz:
https://doaj.org/article/ae8cd71bd8374ad680c8e90aa28c510e
Publikováno v:
F1000Research, Vol 7 (2018)
B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during
Externí odkaz:
https://doaj.org/article/3e5e95e9b1414aa891752f528caac417
Autor:
Michael Meyer-Hermann, Elodie Mohr, Nadége Pelletier, Yang Zhang, Gabriel D. Victora, Kai-Michael Toellner
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 162-174 (2012)
High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell
Externí odkaz:
https://doaj.org/article/ed181baa017f42578bd7014f1f3536b2
Publikováno v:
Clinical and Developmental Immunology, Vol 10, Iss 1, Pp 1-6 (2003)
Externí odkaz:
https://doaj.org/article/ad85192b3fba48b69ea60685e927ee31
Autor:
Claudia Stamm, Julia Barthelmann, Natalia Kunz, Kai-Michael Toellner, Jürgen Westermann, Kathrin Kalies
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67746 (2013)
The differentiation of CD4 T cells into Th1 and Th2 cells in vivo is difficult to analyze since it is influenced by many factors such as genetic background of the mice, nature of antigen, and adjuvant. In this study, we used a well-established model,
Externí odkaz:
https://doaj.org/article/f6760b81023c46cb82c4b72d6bfc0887
Autor:
Karine Serre, Cécile Bénézech, Guillaume Desanti, Saeeda Bobat, Kai-Michael Toellner, Roger Bird, Susan Chan, Philippe Kastner, Adam F Cunningham, Ian C M Maclennan, Elodie Mohr
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20731 (2011)
BACKGROUND:Although in vitro IL-4 directs CD4 T cells to produce T helper 2 (Th2)-cytokines, these cytokines can be induced in vivo in the absence of IL-4-signalling. Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribu
Externí odkaz:
https://doaj.org/article/cc8a133ab69344678538562796e35e36