Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kai-Dietrich Nüsken"'
Autor:
Seif El Din Abo Zed, Agnes Hackl, Katrin Bohl, Lena Ebert, Emilia Kieckhöfer, Carsten Müller, Kerstin Becker, Gregor Fink, Kai-Dietrich Nüsken, Eva Nüsken, Roman-Ulrich Müller, Bernhard Schermer, Lutz T. Weber
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Mycophenolate Mofetil (MMF) has an established role as a therapeutic agent in childhood nephrotic syndrome. While other immunosuppressants have been shown to positively affect podocytes, direct effects of MMF on podocytes remain largely unkn
Externí odkaz:
https://doaj.org/article/bc441651c3b3468da8d9a00ea5e35e1d
Autor:
Eva Nüsken, Sarah Appel, Leon Saschin, Celien Kuiper-Makris, Laura Oberholz, Charlotte Schömig, Anne Tauscher, Jörg Dötsch, Angela Kribs, Miguel A. Alejandre Alcazar, Kai-Dietrich Nüsken
Publikováno v:
Cells, Vol 13, Iss 6, p 501 (2024)
Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the te
Externí odkaz:
https://doaj.org/article/b0f94b18def14f26824bba1d8b9fc383
Autor:
Andrea Kodde, Mona Mischke, Maryam Rakhshandehroo, Jenny Voggel, Gregor Fink, Eva Nüsken, Manfred Rauh, Eline M. van der Beek, Jörg Dötsch, Kai-Dietrich Nüsken
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-6 (2021)
Abstract Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We previously showed that a postnatal diet with an adapted lipid droplet structure can ameliorate s
Externí odkaz:
https://doaj.org/article/506ebc937f4d48bda0048590b423d155
Autor:
Jenny Voggel, Gregor Fink, Magdalena Zelck, Maria Wohlfarth, Julia M. Post, Laura Bindila, Manfred Rauh, Kerstin Amann, Miguel A. Alejandre Alcázar, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüsken
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100283- (2022)
Intrauterine growth restriction (IUGR) predisposes to chronic kidney disease via activation of proinflammatory pathways, and omega-3 PUFAs (n-3 PUFAs) have anti-inflammatory properties. In female rats, we investigated 1) how an elevated dietary n-3/n
Externí odkaz:
https://doaj.org/article/77447104036847488c140dd450ba8acb
Autor:
Vivi F H Jensen, Anne-Marie Mølck, Jette Nowak, Maria Wohlfarth, Eva Nüsken, Damien Demozay, Kai-Dietrich Nüsken, Ingrid B Bøgh
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265988 (2022)
Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutri
Externí odkaz:
https://doaj.org/article/9a0a516057bc45e7af4128d5a8bdcacf
Autor:
Jaco Selle, Katrin Bohl, Katja Höpker, Rebecca Wilke, Katharina Dinger, Philipp Kasper, Bastian Abend, Bernhard Schermer, Roman-Ulrich Müller, Christine Kurschat, Kai-Dietrich Nüsken, Eva Nüsken, David Meyer, Soni Savai Pullamsetti, Björn Schumacher, Jörg Dötsch, Miguel A. Alejandre Alcazar
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2508 (2023)
Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension, and diabetes, which are all frequent consequences of obesity. Despite extensive studies, the mechanisms determining su
Externí odkaz:
https://doaj.org/article/aa1ecb74ea244897b4213dd1c276c97d
Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction
Autor:
Charlotte Schömig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Jörg Dötsch, Kai-Dietrich Nüsken, Eva Nüsken
Publikováno v:
Nutrients, Vol 14, Iss 3, p 451 (2022)
Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we examined hippocampal cellular composition and mTOR signaling of male rat FGR offspring during
Externí odkaz:
https://doaj.org/article/448abbb847224ea4942f682f62af236f
Publikováno v:
Frontiers in Pediatrics, Vol 6 (2018)
Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important
Externí odkaz:
https://doaj.org/article/6127e119a48944039ac3e878e7597acf
Autor:
Eva Nüsken, Eva-Maria Turnwald, Gregor Fink, Jenny Voggel, Christopher Yosy, Tobias Kretschmer, Marion Handwerk, Maria Wohlfarth, Lutz T. Weber, Eva Hucklenbruch-Rother, Jörg Dötsch, Kai-Dietrich Nüsken, Sarah Appel
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 5, p 663 (2019)
There is accumulating evidence for fetal programming of later kidney disease by maternal obesity or associated conditions. We performed a hypothesis-generating study to identify potentially underlying mechanisms. Female mice were randomly split in tw
Externí odkaz:
https://doaj.org/article/4dd49d4dc6d9487fb10fda5707ea80cb
Autor:
Jörg Dötsch, Kai-Dietrich Nüsken, Jenny Voggel, Bent Brachvogel, Felix Lechner, Eva Nüsken, Max C. Liebau, Lutz T. Weber, Lisa Sprenger, Gregor Fink, Nava Mehdiani, Maria Wohlfarth
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract This study was performed to identify transcriptional alterations in male intrauterine growth restricted (IUGR) rats during and at the end of nephrogenesis in order to generate hypotheses which molecular mechanisms contribute to adverse kidne